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The Promise of CBD, the Cannabis Chemical That Won’t Get You High

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Re: The Promise of CBD, the Cannabis Chemical That Won’t Get You High

#51

Earlier quoted context omitted.

Would CBD show on a typical 5-panel test which tests for THC?

Well it's a completely different molecule than THC, so no.

that's not the way screens work. definitely not the way immunoassay screens work, which is the most common screen that isn't just making shit up.

confirmatory testing, like a GC/MS or LC/MS/MS can tell them apart because they're different molecules, but the extraction processes for delta 9 THC can/will pick up all the similar molecules (delta 8, COOH, CBD, CBN, whatever).

that's necessary and good because they're not all psychoactive (the COOH in particular), so they've got to be separated out for forensic purposes.

Re: The Promise of CBD, the Cannabis Chemical That Won’t Get You High

#52

So I've experimented consistently with pure CBD (0 THC. Even 16:1 CBD:THC is too much for me). In my opinion, it's better than weed, at least for those of us who are more sensitive to marijuana than most (e.g. I probably couldn't drive high). I'm not saying I put it in my coffee every morning, but the relaxing effect is real and powerful. Certainly a better substance than alcohol for taking the edge off in my opinion…

Would CBD show on a typical 5-panel test which tests for THC?

a cannabinoids immunoassay will tend to react with most of the cannabinoid-esque compounds. so, it's not a question of whether or not the test will "show" CBD, but rather, how much CBD is necessary to get the test to think there was an interesting/actionable amount of THC in the sample.

it works as a sort of linearish equation, where you add up all the compounds at different ratios, like 1.0THC + 0.5COOH + 0.05CBD + 0.05CBN + ... and if that adds up to "enough" then the test will trigger the testing lab to consider the screen positive.

at that point hopefully it goes over to confirmatory testing, where the LC/MS/MS separates all the various compounds apart, and lets the lab know that you had CBD in your system, but not THC.

Re: The Promise of CBD, the Cannabis Chemical That Won’t Get You High

#53
I'm shadowbanned so I don't know why I respond to things anymore but...

Hemp-derived cbd is legal in all 50 states, which is appealing for legal reasons, but I've found cannabis derived cbd is much more effective.

Also, please be careful and research what you are injesting. There are a lot of cbd oils these days that have added terpenes and other things. If you can't find a scientific terpene profile I wouldn't use it, or even better, use things without the added stuff.

As a comat vet with ptsd I think it's a moral outrage that the one easy to grow plant that helps me and my buddies is illegal. Personally, I also think it's unconstitutional as well, but there is a good debate to be had (that I haven't seen yet) about states abuse of general welfare and health clauses to justify their attacks on it, along with good discussion about the abuse of the Commerce clause at the federal level.

Ps; dang, this isn't an alt, I changed my password without looking on the other account.

Re: The Promise of CBD, the Cannabis Chemical That Won’t Get You High

#54

I've tried full spectrum CBD from a reliable source and I'm jealous of everyone who seem to be reaping all of these benefits. I'm unfortunately not on that side of the fence. I've tried different doses from tinctures under the tongue etc...but I couldn't say I notice any difference in mood, anxiety, muscle soreness, joint pain et al.

[deleted]

Re: The Promise of CBD, the Cannabis Chemical That Won’t Get You High

#55
CBD is a CB1 receptor antagonist, which means it suppresses activity in those receptors which are found in the brain and the tissues of other organs throughout the entire body. Excess CB1 activity seems to be implicated in many different disorders (most notably obesity).

Chronic CB1 receptor antagonism is associated with:

- lowered blood pressure

- increased levels of Akkermensia bacteria in the gut (associated with leanness)

- decreased lipogenesis (creation of new fat cells)

- decreased fat masss

- resistance to obesity, despite caloric surplus

- increased fatty acid oxidation

- increased adiponectin

- increased transdifferentiation of white fat into metabolically active brown fat

- increased insulin sensitivity

- reduced insulin levels

- increased leptin sensitivity

- reduced proteinurea and improved creatinine clearance in kidney disease

- smoking and cocaine cessation

- reduction in depression symptoms

- reduced anxiety

Search PubMed for "CB1 antagonist" or "chronic CB1 blockade" to see what kinds of things CB1 antagonism can do. You'll find quite a lot of research into Rimonabant (another CB1 antagonist) but unfortunately it was found to cause psychological side effects like depression and suicidal ideation; CBD does not have these effects.

There are several anecdotal reports the on /r/cbd subreddit where people start taking it for anxiety and depression, and end up losing 10-40 lbs. of excess weight without trying.

I've found that it helps me sleep deeply, helps me focus at work, and I am satiated after much smaller amounts of food than before. I also notice that I can run at a significantly higher intensity on the treadmill for much longer with CBD.

I have recommended CBD to 7 or 8 people, and each one reports a plethora of benefits: helps depression, anxiety, ADHD, sleep, weight loss, brain fog, overeating, etc.

There seems to be a good amount of variety in the quality of non-isolate CBD products. Some contain minute amounts of THC and other psychoactive cannabinoids, so they may cause you to fail a drug test if that's a concern.

CBD is one incredibly beneficial compound. I highly recommend you try it if it's available where you live.

Re: The Promise of CBD, the Cannabis Chemical That Won’t Get You High

#56
The few times I've tried CBD oil it turned me into an extrovert like a light switch. Normally being quite introverted, I found the experiences interesting but exhausting.

Another product which I've found has a very similar effect on me, albeit weaker, is 5-HTP supplements taken orally.

Sometimes I'd take a large 5-HTP dose then go out to used book stores, talking to everyone I encountered. It's fun to occasionally visit being that person, but it's such foreign territory I'm not particularly good at it and by the end of the day it feels like I've been working at some horrible, inane, unfamiliar job. I don't know how extroverts find the energy for all the interaction while still getting shit done.

CBD was probably having other effects on me, but the extroversion was the most prominent from what I recall.

Re: The Promise of CBD, the Cannabis Chemical That Won’t Get You High

#58
I have the start of arthritis in my hands. I just spent $50 on a topical salve with hemp-derived CBD oil after reading a lot of reviews about how effective it is.

The next day I checked if there was any research on its efficacy. Due to the volume of pages touting the benefits of CBD, finding the actual research was difficult. Most of the search results were either vendors or medical mj boosters.

The best I found was this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/

Sure enough, CBD did help reduce inflammation and increased joint mobility in arthritic rats ... at a dose of 6.2mg/day. Considering that I'm hundreds of times more massive than a rat, and that my 2oz jar contains 150mg of CBD oil total, I'm probably getting 2mg of CBD oil per application.

That seems to confirm that the self-reported benefits of topical CBD oil is mostly placebo effect.

Re: The Promise of CBD, the Cannabis Chemical That Won’t Get You High

#59

Earlier quoted context omitted.

under the tongue intake ? I'm wondering if it's possible to inhale CBD with the old bowl of near boiling water.

Dissolving under the tongue, for like 1-2 minutes, is the most common application advice I've seen with CBD oils.

But does it actually make any difference?

Re: The Promise of CBD, the Cannabis Chemical That Won’t Get You High

#60

I have the start of arthritis in my hands. I just spent $50 on a topical salve with hemp-derived CBD oil after reading a lot of reviews about how effective it is. The next day I checked if there was any research on its efficacy. Due to the volume of pages touting the benefits of CBD, finding the actual research was difficult. Most of the search results were either vendors or medical mj boosters. The best I found was…

Get a salve made with cannabis and other plants. Something like: http://www.papaandbarkley.com/product/releaf-balm/
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