I'm also a long-time user of Dart, so when he brought that up, and compared TypeScript to its shortcomings, I definitely agreed.
That being said, even with the Deno project, I'm not so sure what can come in terms of performance and security from running JavaScript outside of a browser. The choice of V8 also raises concerns for me about build systems. He mentioned the failing of GYP, but anything using the same build toolchain as Chromium always introduces a wealth of complexity for anyone building said software, as not only do you need Google-specific build tools, but also very specific configuration including Python.
It will be interesting to see what comes in the future.
If it were up to me (which I guess it isn't), I'd probably prioritize portability/less complex builds, built-in FFI, a flat module system, and optimizing calls to C from JS.