Some background on this: NASA deep space missions have historically used radioisotope thermal generators powered by the decay of the exotic plutonium isotope Pu-238. This isotope has a good balance of lifetime (87.7 year half life) and specific energy (0.5 watts/gram). It is non-fissile -- no risk of criticality. It also decays solely by alpha emission, so there are no problems with shielding the rest of the systems…
The major fear that comes up with these is: what if the missile blows up while still in earth? How are these risks managed?
The new fuel rods going into it are totally safe from a radioactivity perspective. Here's a picture of a man holding a fuel rod bundle with nothing more than gloves on. http://nuclearstreet.com/images/img/dw037.jpg