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Cancer ‘vaccine’ eliminates tumors in mice

med.stanford.edu

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Re: Cancer ‘vaccine’ eliminates tumors in mice

#181

Post by jcims »

hwillis wrote: post #77
jcims wrote: post #55

Writing this from a squeaky recliner set beside my wife’s bed in the oncology department of a local research hospital. Three weeks ago she had a radical hysterectomy and partial lymphadenectomy to treat stage IIIc ovarian cancer, and we’re back to try to aid her in her recovery to prepare for chemotherapy. Chemo should start next week, but we are hoping to also participate in a clinical trial for atezolizumab. This i…

Squeeze her hand for a stranger. Every person who has lost someone to cancer, and everyone who has survived it, and all of the people who watched that fight- all of us have her back and stand with her. She's fighting one of the hardest battles put to a person, and she has our respect and awe. I saw my friend at his weakest, and also when he was stronger than anyone I've ever known. It's been years but still, I'm cryi…

(squeeze delivered btw, thanks again)

Re: Cancer ‘vaccine’ eliminates tumors in mice

#182

Post by westurner »

The article is about this study:

"Eradication of spontaneous malignancy by local immunotherapy" http://stm.sciencemag.org/content/10/426/eaan4488

> In situ vaccination with low doses of TLR ligands and anti-OX40 antibodies can cure widespread cancers in preclinical models.

Re: Cancer ‘vaccine’ eliminates tumors in mice

#183

Post by hwillis »

jcims wrote: post #181
hwillis wrote: post #77

Earlier quoted context omitted.

Squeeze her hand for a stranger. Every person who has lost someone to cancer, and everyone who has survived it, and all of the people who watched that fight- all of us have her back and stand with her. She's fighting one of the hardest battles put to a person, and she has our respect and awe. I saw my friend at his weakest, and also when he was stronger than anyone I've ever known. It's been years but still, I'm cryi…

(squeeze delivered btw, thanks again)

:D

Re: Cancer ‘vaccine’ eliminates tumors in mice

#184

Post by cryoshon »

invalid-access wrote: post #166
cryoshon wrote: post #104

Earlier quoted context omitted.

as a former immunooncology scientist i'd say you should be guardedly optimistic. you should be aware that there probably won't be a generalized cancer cure, but i think we'll be starting to tackle a lot of different cancers in the next 2-3 years, just like we have been for the previous 3-5 years. beyond that, who knows. immunotherapies don't work for 100% of people or 100% of cancers, and some cancers seem to grow re…

Thanks for the info! For people outside this field of work like me (a software / cleantech guy), is there a concise spreadsheet to show the state-of-the-art? i.e. Listing different types of cancers with the most promising immunotherapy treatments for each type, expected confidence and success rates, trials that one can enroll into? It'd be a good first place to go to whenever we hear of someone who has 'cancer' - tha…

> is there a concise spreadsheet to show the state-of-the-art

doubtful imo. the state of the art is rapidly changing, and plenty of things are happening behind closed doors.

clinicaltrials.gov is your best bet but the expected success rates is not something anyone would willingly have as public information.

Re: Cancer ‘vaccine’ eliminates tumors in mice

#185

Post by [deleted] »

cryoshon wrote: post #96
jcims wrote: post #55

Writing this from a squeaky recliner set beside my wife’s bed in the oncology department of a local research hospital. Three weeks ago she had a radical hysterectomy and partial lymphadenectomy to treat stage IIIc ovarian cancer, and we’re back to try to aid her in her recovery to prepare for chemotherapy. Chemo should start next week, but we are hoping to also participate in a clinical trial for atezolizumab. This i…

as a former scientist in immunotherapy/immunooncology research: we are going to win against cancer. and very importantly for you and your wife, many of us consider the PD-1 therapies as the biggest battles and biggest victories that we've ever won against cancer. it is extremely difficult to overstate how powerful the anti-PD-1/L1 biologics are. and it's also extremely hard to overstate how much research scientists i…

[deleted]

Re: Cancer ‘vaccine’ eliminates tumors in mice

#186

Post by epmaybe »

matte_black wrote: post #136
epmaybe wrote: post #130

Earlier quoted context omitted.

My gut tells me that if the treatment is given for free (my original comment mentioned I was concerned if the company was charging for said treatments) then there's far less of a problem. However, there's still this incentive for a company to take advantage of this situation. Giving the treatment for free could technically be cheaper than providing the drug in a trial while also paying a participant.

So? Earlier human trials means faster to market drugs means competitive advantage.

I wanted to update you with some new information I remembered. There is already legislation that allows for this, called the Compassionate Use Act. The difference being that the FDA is required to be involved, giving final say on if the doctor and pharmaceutical company can administer the mtreatment to the patient.

Re: Cancer ‘vaccine’ eliminates tumors in mice

#187

Post by adbachman »

jcims wrote: post #55

Writing this from a squeaky recliner set beside my wife’s bed in the oncology department of a local research hospital. Three weeks ago she had a radical hysterectomy and partial lymphadenectomy to treat stage IIIc ovarian cancer, and we’re back to try to aid her in her recovery to prepare for chemotherapy. Chemo should start next week, but we are hoping to also participate in a clinical trial for atezolizumab. This i…

We’re 7 years on from stage 1b, similarly drastic surgery (“the works”), eternally grateful that we had kids before. No recurrence but we’ll be watching and waiting forever. My wife is still the youngest person at her doctor’s office by ~20 years so it’s a long goddamn road ahead.

I knew cancer was bad and had a lot of research surrounding it, but I was blown away by the uncertainty for patients and the incredible amount of resources put into solving/treating the disease and supporting the people going through it. After immunization, chemotherapy is probably the most important medical discovery in human history. If immunotherapy can carry us past that, how amazing!

The immunosuppressive therapies are new since we went through treatment and I’m hopeful. If or when we have to fight again, we’ll have new weapons, I’m optimistic.

I hope you find strength, comfort, and support enough to be a support for your wife. Others have gone through it, empathize, and are rooting for you. Fuck cancer.

Re: Cancer ‘vaccine’ eliminates tumors in mice

#188

Post by kkartik »

jcims wrote: post #87
kkartik wrote: post #83

Earlier quoted context omitted.

Sorry to know of your situation. If you want to learn more about a trial in this space (currently enrolling) let me know, I can help.

Always interested in learning our options, thank you!

Sorry for the delay. I don't check HN often. Pls email me on kkartik@gmail.com with subject line Ovarian Cancer Trial. I can put you in touch with the Professor conducting it.

https://today.uconn.edu/school-stories/recruitment-begins-wo...

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