Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Ibuprofen alters human testicular physiology

pnas.org

Post reply on HN
Print view View original

201–210 of 216 posts

Re: Ibuprofen alters human testicular physiology

#201

Post by deadmetheny »

acchow wrote: post #90
kinkrtyavimoodh wrote: post #18

Earlier quoted context omitted.

I sometimes imagine, with horror, what would happen if after 500 years of progress, humanity were to realize that almost all cultural practices they painfully, one by one, undid, were all sensible to begin with for reasons that humanity didn't previously understand.

“If the stars should appear one night in a thousand years, how would men believe and adore; and preserve for many generations the remembrance of the city of God”

Or, alternatively, you'll be driven mad by the sight and your entire civilization will collapse.

http://www.astro.sunysb.edu/fwalter/AST389/TEXTS/Nightfall.h...

Re: Ibuprofen alters human testicular physiology

#202

Post by xaedes »

seibelj wrote: post #36

As much as possible, I believe we should all try to do everything in moderation. Never be too extreme in medicine, exercise, drinking, drugs, food, etc. Sometimes in life you can't avoid the situation, unfortunately.

Also known to some as the "Middle Way": [1]

In the Pāli Canon of Theravada Buddhism, the term "Middle Way" was used in the Dhammacakkappavattana Sutta, which the Buddhist tradition regards to be the first teaching that the Buddha delivered after his awakening. In this sutta, the Buddha describes the Noble Eightfold Path as the middle way of moderation, between the extremes of sensual indulgence and self-mortification

[1] https://en.wikipedia.org/wiki/Middle_Way

Re: Ibuprofen alters human testicular physiology

#203

Post by sov »

carlmr wrote: post #189
function_seven wrote: post #165

Earlier quoted context omitted.

You had to introduce a lot of assumptions to invalidate the n=31. So let me lay it out in more detail. I recruited 31 white men who self-report having no hair on at least 500cm^2 of their head. They all had hair as adolescents, and lost it gradually throughout their 20s or early 30s. They're all at least 37 now. I then sort them into the two groups by assigning sequential IDs in random order. Those with an odd ID are…

The point is though, that if enough people do the same study, and only the positive results are published, you're increasing the odds a lot of getting a positive result from someone. That's why companies often finance studies in their drugs. If enough people study their drugs, something which doesn't have a measureable effect, might have a measureable effect in some of these studies. At which sample size this becomes…

How many studies, on average, does it take to show an effect p<=0.05 for n=31 where none exists? How many for n=200?

Re: Ibuprofen alters human testicular physiology

#204

Post by xaedes »

sov wrote: post #53
3pt14159 wrote: post #30

Earlier quoted context omitted.

It isn't. People talking about P values forget about p-hacking and selection bias. Any scientific study with less than 200 participants should be discarded and the failure to routinely do so has more to do with scientific laziness and the pro-profit incentive most journals have than anything else.

That's not entirely true and doesn't really convey the right message about p-values or study size. P-hacking and selection bias are definite concerns, but they're also concerns for studies with 200, or more, participants. Rather, we should put more of an emphasis on the statistical power of the study. We're not yet in the beautiful golden world of pre-registered studies, but even high-n studies can have huge disparit…

I had to look up what you meant by pre-registered studies. In case anyone else wonders:

"Unlike traditional scientific publishing, in which manuscripts are peer reviewed only after studies have been completed, registered reports are reviewed before scientists collect data. If the scientific question and methods are deemed sound, the authors are then offered "in-principle acceptance" of their article, which virtually guarantees publication regardless of how the results turn out."

https://www.theguardian.com/science/blog/2013/jun/05/trust-i...

Re: Ibuprofen alters human testicular physiology

#205

Post by TylerE »

dogma1138 wrote: post #147
TylerE wrote: post #129

Earlier quoted context omitted.

That sort of logic has never made sense to me. It's as if the regulators think people would never take more than one at a time.

You can’t buy more than 2 packs of 200-250mg ibo in the UK at the time, and only one pack of anything higher, doses above 500mg require a prescription. Prescription Ibo can be 2000-5000mg per pill so yes it does reduce the risk.

That's... different. Here in the US I can walk into into any pharmacy or supermarket and buy a bottle of 500 or even 1000 200mg does for <$20.

Re: Ibuprofen alters human testicular physiology

#206

Post by rconti »

saurik wrote: post #191
randallsquared wrote: post #173

Earlier quoted context omitted.

TIL that my pain is weak and mild, even when I think I'm in a lot of pain. I'm well over 200 lbs (still), but 200mg of ibuprofen usually eradicates whatever pain I have. If it's really bad pain, then I take 400mg.

TIL I have only experienced pain a few times in my life, and this apparently doesn't even include when I have had extensive dental work done as I don't let them give me any novocaine and don't mind them drilling into my teeth or cord packing my gums. I am really hoping that it isn't just that you all are like, five years older than I am, and so I have to expect that I am going to just end up in pain a lot soon :/.

I really have no idea where you got that from in this thread.

Re: Ibuprofen alters human testicular physiology

#207

Post by User23 »

MollyR wrote: post #3

It would be mind boggling if pain killers were connected to dropping male fertility. It might even explain why so many cultures had rites to male adulthood involving extreme pain.

You are absolutely correct. Pain is far more than a simple signaling mechanism to tell you to take your hand off the stove.

One of its more interesting applications is as a pathway to mystical experiences. In the Christian tradition for example one uses one's own pain to come into a kind of spiritual alignment with Christ's experience and in that way become closer to God.

I'm not particularly familiar with other spiritual traditions, but I'd be shocked if every single major one doesn't have some kind of mystical algetic praxis.

Re: Ibuprofen alters human testicular physiology

#208

Post by User23 »

kinkrtyavimoodh wrote: post #18
MollyR wrote: post #3

It would be mind boggling if pain killers were connected to dropping male fertility. It might even explain why so many cultures had rites to male adulthood involving extreme pain.

I sometimes imagine, with horror, what would happen if after 500 years of progress, humanity were to realize that almost all cultural practices they painfully, one by one, undid, were all sensible to begin with for reasons that humanity didn't previously understand.

This is basically the position of the alt-right, neoreaction, and similar "movements."

Re: Ibuprofen alters human testicular physiology

#209

Post by sctb »

iron0012 wrote: post #197
bawana wrote: post #193

In this age of political correctness, who needs testicles anyway?

Certainly not whiny little babies like you.

Would you mind starting to post according the guidelines? We ban accounts that won't.

https://news.ycombinator.com/newsguidelines.html

Re: Ibuprofen alters human testicular physiology

#210

Post by manyxcxi »

adventured wrote: post #153
manyxcxi wrote: post #79

Earlier quoted context omitted.

I can’t take Ibuprofen (or any typical NSAIDS including aspirin) because of a medical condition, which has sucked over the last decade because acetaminophen really doesn’t help me at all when I’m excruciatingly sore for whatever reason. In Oregon and Washington, where I’ve lived for pretty much my entire life, legal marijuana has been amazingly helpful, at least since I finally got around to trying it. The various pr…

If you don't mind answering (as vaguely as makes sense), what kind of pain? Where is it focused (exclusively the hip/s?), what does it derive from? Depending on the nature of it, you might look at this: https://www.amazon.com/Genacol-Hydrolyzed-Supplement-Extra-F... I'll suggest you do your own research on it of course. I've known a few people, myself included, that have seen extraordinary results from taking it for…

I had to have hip arthroscopy because I had an impingement, leading to quite a bit of cartilage damage/labral tearing in the joint. They even had to reshape the end of the femur to remove the impingement. It's quite a recovery period of crutches, cane, etc. and the pain from the surgery was _supposed_ to be quite immense. Honestly, my hip hurt so bad for so long that even a day post-op it was less painful than it was when I went in. I only needed the opiates for a couple of days and used CBD once or twice a day for about a week- after that the pain was just a dull soreness.

Luckily, there was very little arthritis in the joint and three years post-op it's felt just fine and I've had no set backs whatsoever. Luckily I've not had to look into any type of long term pain management for anything.

Post reply on HN