Earlier quoted context omitted.
some people can't handle the effect on the stomach. but if you can handle it, it's a good choice. Or marijuana
> marijuana Unless that makes you anxious.
Unless you're not in a marijuana friendly jurisdiction
Ibuprofen alters human testicular physiology
121–130 of 216 posts
Re: Ibuprofen alters human testicular physiology
#122Earlier quoted context omitted.
1000 cases in the US, which means you're about 30x more likely to die in a car accident in any given year. Also, the syndrome isn't immediately lethal. When people worry about infinitesimally small risks, it always makes me chuckle.
That's 1000 cases when we restrict children from taking aspirin, it could be a lot more once we let them
No, Reyes is very rare even when parents gave sick kids chewable baby aspirin almost like candy.
Re: Ibuprofen alters human testicular physiology
#123Earlier quoted context omitted.
That's 1000 cases when we restrict children from taking aspirin, it could be a lot more once we let them
No, it was under 1000 cases per year in the US before the association with aspirin was known. Over the next 14 years it dropped to about 2 per year.
I had Reye syndrome without having taken aspirin.
Obviously one person commenting doesn't disprove your point at all. But it's an odd feeling to be that person.
Re: Ibuprofen alters human testicular physiology
#124Earlier quoted context omitted.
I've had two doctors suggest taking over 2000mg a day like it was nothing. One of them was a fellow hiker on the Appalachian Trail and suggested it as a daily regimen for regular joint pain (common for long-distance hikers). The other suggested it for aiding recovery from mild frostnip. (In both cases, I ended up only taking it for a few days.) Unless you have stomach problems—NSAIDs are linked to ulcers—high doses o…
My nephrologists all say NSAIDs on long term use have a risk for acute kidney failure. They say Tylenol is safe in long term as long as liver is otherwise healthy and you stay under daily dosage limit.
Yeah, Tylenol damages the liver instead.
Re: Ibuprofen alters human testicular physiology
#125Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?
Good Scotch?
Re: Ibuprofen alters human testicular physiology
#126Earlier quoted context omitted.
1000 cases in the US, which means you're about 30x more likely to die in a car accident in any given year. Also, the syndrome isn't immediately lethal. When people worry about infinitesimally small risks, it always makes me chuckle.
1000 cases in the US because there are no child friendly pain medications (sweet syrup and oral syringe) but by all means risk your child’s liver to prove us all wrong
Quite normal in the UK to use calpol (paracetomol) and nurofen (ibuprufen) in a 5ml syringe (doses at 2.5, 5, 7.5 and 10 as the child gets older).
What do you do in the US?
Re: Ibuprofen alters human testicular physiology
#127Not a doctor / scientist. Can anyone tell me if this is a pilot study or reproduced results from other studies? Or in other words, should I take this as a fact yet?
Re: Ibuprofen alters human testicular physiology
#128Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?
Can't use aspirin in children and teenagers because of the risk of Reye's Syndrome. https://www.mayoclinic.org/diseases-conditions/reyes-syndrom...
The link to aspirin is dubious at best, which is why it’s always phrased as “linked to,” rather than any language endorsing causality.
We’ve simply gone with a policy of “better safe than sorry,” because of the risks/benefits involved here.
Re: Ibuprofen alters human testicular physiology
#129Earlier quoted context omitted.
Funny thing, naproxen is much kinder to your stomach than ibuprofen, but it's not generally used (and may be prescription-only?), in Australia at least. It does, however, carry a minutely increased risk of heart attack / stroke. I guess they'd rather give 1000 people ulcers than 1 more person die in a lawsuit-attracting fashion.
Naproxen is OTC in the US, as Aleve, but you need a prescription for higher doses, like with ibuprofen.
That sort of logic has never made sense to me. It's as if the regulators think people would never take more than one at a time.
Re: Ibuprofen alters human testicular physiology
#130Earlier quoted context omitted.
It isn't. People talking about P values forget about p-hacking and selection bias. Any scientific study with less than 200 participants should be discarded and the failure to routinely do so has more to do with scientific laziness and the pro-profit incentive most journals have than anything else.
That's not entirely true and doesn't really convey the right message about p-values or study size. P-hacking and selection bias are definite concerns, but they're also concerns for studies with 200, or more, participants. Rather, we should put more of an emphasis on the statistical power of the study. We're not yet in the beautiful golden world of pre-registered studies, but even high-n studies can have huge disparit…
I'm essentially right. Studies with less than 200 people are essentially useless. It is more complicated than I originally let on, but not so much more complicated to muck up the takeaway. Most of our junk science has to do with these low population studies or with studies simultaneously studying high numbers of attributes.