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Ibuprofen alters human testicular physiology

pnas.org

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Re: Ibuprofen alters human testicular physiology

#51

Post by canjobear »

3pt14159 wrote: post #30
diryawish wrote: post #6

How sufficient is a sample size of 31 healthy white men?

It isn't. People talking about P values forget about p-hacking and selection bias. Any scientific study with less than 200 participants should be discarded and the failure to routinely do so has more to do with scientific laziness and the pro-profit incentive most journals have than anything else.

The number of participants required to show an effect should be shown by power analysis. It depends a lot on the effect being investigated. An arbitrary number like 200 is not helpful.

Re: Ibuprofen alters human testicular physiology

#52

Post by tlb »

karlkatzke wrote: post #31
Alex3917 wrote: post #15

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

Ibuprofen doesn’t work as an anti inflammatory until you take at least 2400mg/day.

I was recommended 1200mg/day for carpal tunnel inflammation, and it helped.

Re: Ibuprofen alters human testicular physiology

#53

Post by sov »

3pt14159 wrote: post #30
diryawish wrote: post #6

How sufficient is a sample size of 31 healthy white men?

It isn't. People talking about P values forget about p-hacking and selection bias. Any scientific study with less than 200 participants should be discarded and the failure to routinely do so has more to do with scientific laziness and the pro-profit incentive most journals have than anything else.

That's not entirely true and doesn't really convey the right message about p-values or study size. P-hacking and selection bias are definite concerns, but they're also concerns for studies with 200, or more, participants. Rather, we should put more of an emphasis on the statistical power of the study. We're not yet in the beautiful golden world of pre-registered studies, but even high-n studies can have huge disparities due to bad statistical power (eg: The Control Group is Out of Control).

Re: Ibuprofen alters human testicular physiology

#55

Post by ChristianGeek »

TheSpiceIsLife wrote: post #38
StreamBright wrote: post #22

Earlier quoted context omitted.

Well you can still use CBD though.

In case you were wondering: Cannabidiol (INN;[3] abbreviated as: CBD) is one of at least 113 active cannabinoids identified in cannabis.[4][5] It is a major phytocannabinoid, accounting for up to 40% of the plant's extract. https://en.wikipedia.org/wiki/Cannabidiol

It’s worth noting that a legal version, extracted from Hemp (a form of Cannabis that has no psychoactive properties), is available via mail order anywhere in the U.S.

Re: Ibuprofen alters human testicular physiology

#56

Post by aroman »

karlkatzke wrote: post #31
Alex3917 wrote: post #15

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

Ibuprofen doesn’t work as an anti inflammatory until you take at least 2400mg/day.

Here is a study[0] which directly contradicts that claim:

"Thus, the higher dose of ibuprofen (2400 mg per day) was not superior to either the dose of acetaminophen (4000 mg per day) or the lower dose of ibuprofen (1200 mg per day) for pain relief or improvement of function."

http://www.nejm.org/doi/full/10.1056/NEJM199107113250203#t=a...

Re: Ibuprofen alters human testicular physiology

#58

Post by 6nf »

cookiecaper wrote: post #50
Alex3917 wrote: post #15

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

Yeah, I have to say "Common drug X has negative side effects after sustained daily exposure to high dosages" is hardly surprising. The study says participants were given 1200mg per day for six weeks. For reference, a typical ibuprofen capsule in the US is 200mg. I'm sure this result is useful for the medical community or men specifically dealing with hypogonadism, but it doesn't seem to have a great deal of relevance…

1200mg is only 2 capsules 3 times per day, less than the maximum recommended for over the counter use. However any pharmacist would tell you not to use it for more than a few days in a row without seeing a doctor.

Re: Ibuprofen alters human testicular physiology

#59

Post by gknoy »

cookiecaper wrote: post #50
Alex3917 wrote: post #15

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

Yeah, I have to say "Common drug X has negative side effects after sustained daily exposure to high dosages" is hardly surprising. The study says participants were given 1200mg per day for six weeks. For reference, a typical ibuprofen capsule in the US is 200mg. I'm sure this result is useful for the medical community or men specifically dealing with hypogonadism, but it doesn't seem to have a great deal of relevance…

> 1200mg per day for six weeks. For reference, a typical ibuprofen capsule in the US is 200mg.

Most people take 1-2 capsules (400mg), and the dosage documentation says no more than 8 per day (1600mg). The study seems to demonstrate people using the drug well within its over-the-counter maximum dosage. (When I tore up my knee as a teenager, my doctor prescribed it at about double that rate.)

Re: Ibuprofen alters human testicular physiology

#60

Post by anigbrowl »

diryawish wrote: post #6

How sufficient is a sample size of 31 healthy white men?

It isn't, but that's how you pitch for more research funding. I don't know anything about the economics of clinical studies or grant issuance, but I imagine it's hard to get the cash for a large sample up front so researchers go through this scaling process.
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