How sufficient is a sample size of 31 healthy white men?
This is what P-values are for
Perhaps explain how P-values are to be used in this case, for the lay of us.
Ibuprofen alters human testicular physiology
21–30 of 216 posts
Re: Ibuprofen alters human testicular physiology
#22Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?
Well you can still use CBD though.
Re: Ibuprofen alters human testicular physiology
#23If you hang around bodybuilding forums you will hear to avoid Ibuprofens as they hurt your ‘gains’
Perhaps bro-science was right in this case
Re: Ibuprofen alters human testicular physiology
#24It would be mind boggling if pain killers were connected to dropping male fertility. It might even explain why so many cultures had rites to male adulthood involving extreme pain.
I sometimes imagine, with horror, what would happen if after 500 years of progress, humanity were to realize that almost all cultural practices they painfully, one by one, undid, were all sensible to begin with for reasons that humanity didn't previously understand.
What an interesting writing prompt
Re: Ibuprofen alters human testicular physiology
#25How sufficient is a sample size of 31 healthy white men?
This is what P-values are for
Not really. I mean in an ideal world yes, but right now we have no idea how many other people did a similar study, found no difference, and just didn't publish anything. Let alone accidental or purposeful p-hacking.
Re: Ibuprofen alters human testicular physiology
#26At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.
I've been prescribed up to 2400mg/d for a few weeks to deal with my knee. Not for the painkilling aspect (Because it wasn't painful), but for the anti-inflammatory.
Re: Ibuprofen alters human testicular physiology
#27It would be mind boggling if pain killers were connected to dropping male fertility. It might even explain why so many cultures had rites to male adulthood involving extreme pain.
> It might even explain why so many cultures had rites to male adulthood involving extreme pain.
Right. And a notable trend among those cultures is that they are all nearly extinct. So much for their fertility.
Of course this observation could biased due to my own ignorance. I only remember, like, 3 such cultures, and they were your typical African/Amazonian/Aboriginal tribes that still live in near-neolithic conditions.
Is there any industrialized culture that still follows such rituals?
Re: Ibuprofen alters human testicular physiology
#28Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?
I tend to use naproxen but something tells me that would kill me as well
I think that all NSAIDs (like naproxen and ibuprofen) chew holes through your stomach lining, and a whole class of them were yanked from the market for causing heart attacks[1].
(But, yeah, naproxen seems to be one of the safest ones...)
Re: Ibuprofen alters human testicular physiology
#29Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?
some people can't handle the effect on the stomach. but if you can handle it, it's a good choice. Or marijuana
+1 for Marijuana. Both ibpuprofen and aspirin have Ripped my stomach up (I took it every day for eye migraines for years). I still have stomach issues.
Re: Ibuprofen alters human testicular physiology
#30How sufficient is a sample size of 31 healthy white men?
It isn't. People talking about P values forget about p-hacking and selection bias. Any scientific study with less than 200 participants should be discarded and the failure to routinely do so has more to do with scientific laziness and the pro-profit incentive most journals have than anything else.