Live data from Hacker News

Albert Hofmann discovers the effects of LSD (1943)

laphamsquarterly.org

61–70 of 101 posts

Re: Albert Hofmann discovers the effects of LSD (1943)

#61

> I was just barely capable of asking my companion to summon our family doctor and request milk from the neighbors. Hah, hah, a sign of the times. That's the last thing I'd want to injest when in the throws of a deep, harrowing LSD trip, yuck. Really the only thing that "helps", I find, is a watch (if you're able to read the watch that is). Time can help ground you in the sense that you know roughly when the peak wil…

> That's the last thing I'd want to injest when in the throws of a deep, harrowing LSD trip, yuck.

I imagine he wanted to ingest milk in the throes of an LSD trip because he thought it would be the appropriate antidote for what he perceived as poisoning.

> Really the only thing that "helps", I find, is a watch

Yes, but nobody in the world at the time knew how long LSD trips last, or whether you'll be alive at the end of it.

Re: Albert Hofmann discovers the effects of LSD (1943)

#62

Earlier quoted context omitted.

I have this handy bookmark that will remove all top-level unmovable HTML on a page. One click will generally remove all popups and banners that obstruct viewing: javascript:(function()%7B(function%20()%20%7Bvar%20i%2C%20elements%20%3D%20document.querySelectorAll('body%20*')%3Bfor%20(i%20%3D%200%3B%20i%20%3C%20elements.length%3B%20i%2B%2B)%20%7Bif%20(getComputedStyle(elements%5Bi%5D).position%20%3D%3D%3D%20'fixed')%20…

Here's my modified version of Kill Sticky: javascript:(function()%7B(function()%7Bdocument.body.style.overflow%20%3D%20'auto'%3B(function%20()%20%7Bvar%20i%2C%20elements%20%3D%20document.querySelectorAll('body%20*')%3Bfor%20(i%20%3D%200%3B%20i%20%3C%20elements.length%3B%20i%2B%2B)%20%7Bif%20(getComputedStyle(elements%5Bi%5D).position%20%3D%3D%3D%20'fixed')%20%7Belements%5Bi%5D.parentNode.removeChild(elements%5Bi%5D)%…

Would you like to share your version with https://twitter.com/alisdair? Maybe he'll update his, as this is very useful.

Re: Albert Hofmann discovers the effects of LSD (1943)

#63

What’s interesting is when LSD was first discovered and popularized with psychiatrists, it was considered a “model psychosis” - inducing a temporary state of psychosis which researchers could use to study mental problems. That theory was discredited in the late 60’s when it got banned (it was one of the reasons why it was supposed to have no medical value). I believe there’s a lot of truth to it, from my experience i…

> I believe there’s a lot of truth to it, from my experience it totally matches a mini psychotic event. From Wikipedia: "Psychosis is an abnormal condition of the mind that involves a loss of contact with reality." If we use this definition I'd be inclined to differ. LSD only to some extent and under certain circumstances will cause of loss of contact with reality. In my experience LSD intensifies perception and affe…

I have the exact same reaction as you, but many of my friends don't. I'm perfectly lucid and have never lost reality, I just get very intense perception and am hypersensitive to social cues (I read too much into people's reactions).

Re: Albert Hofmann discovers the effects of LSD (1943)

#64
post #52

Given that he didn't know what we know now about LSD (that it's not going to kill you or cause brain damage), his experience was probably a lot more terrifying than the usual bad trip. Not being able to remind yourself that you're safe and that the drug's effects will wear off would make it a lot more scary.

Not only that, but I was struck by the realization of how devastated he must have felt to be dying (or so he thought) after consuming 250 MICROgrams of a substance. The part where he worried about whether his family would think he was reckless for doing this was poignant, because there was no way anyone could have expected 250 micrograms of ergot to produce any sort of observable effect.

http://www.popularmechanics.com/science/health/a14442546/two...

Re: Albert Hofmann discovers the effects of LSD (1943)

#65

Earlier quoted context omitted.

Not only that, but I was struck by the realization of how devastated he must have felt to be dying (or so he thought) after consuming 250 MICROgrams of a substance. The part where he worried about whether his family would think he was reckless for doing this was poignant, because there was no way anyone could have expected 250 micrograms of ergot to produce any sort of observable effect.

http://www.popularmechanics.com/science/health/a14442546/two...

That dose was a few thousand times larger, though.

Re: Albert Hofmann discovers the effects of LSD (1943)

#66

What’s interesting is when LSD was first discovered and popularized with psychiatrists, it was considered a “model psychosis” - inducing a temporary state of psychosis which researchers could use to study mental problems. That theory was discredited in the late 60’s when it got banned (it was one of the reasons why it was supposed to have no medical value). I believe there’s a lot of truth to it, from my experience i…

> I believe there’s a lot of truth to it, from my experience it totally matches a mini psychotic event. From Wikipedia: "Psychosis is an abnormal condition of the mind that involves a loss of contact with reality." If we use this definition I'd be inclined to differ. LSD only to some extent and under certain circumstances will cause of loss of contact with reality. In my experience LSD intensifies perception and affe…

It depends on how extreme your standard for break with reality is. Most trip reports I've read indicate a break with consensus interpretation of reality, which is consistent with psychosis. I have experienced bipolar psychosis twice, and LSD psychosis ~12 times, and subjectively they are far more similar than not. I'd say they are only barely distinguishable by subtle intangibles. Again, subjectively.

Re: Albert Hofmann discovers the effects of LSD (1943)

#67

What’s interesting is when LSD was first discovered and popularized with psychiatrists, it was considered a “model psychosis” - inducing a temporary state of psychosis which researchers could use to study mental problems. That theory was discredited in the late 60’s when it got banned (it was one of the reasons why it was supposed to have no medical value). I believe there’s a lot of truth to it, from my experience i…

> I believe there’s a lot of truth to it, from my experience it totally matches a mini psychotic event. From Wikipedia: "Psychosis is an abnormal condition of the mind that involves a loss of contact with reality." If we use this definition I'd be inclined to differ. LSD only to some extent and under certain circumstances will cause of loss of contact with reality. In my experience LSD intensifies perception and affe…

Overclocking a CPU seems to me to be analogous to a manic episode. So, not too far off to say LSD can be used to mimic a psychotic break.

Re: Albert Hofmann discovers the effects of LSD (1943)

#69
Disclaimer: I probably shouldn't be posting this, even under a throwaway, but I'm on the other side of the international date line, and I've had a few beers tonight. This post is in response to several comments on this thread.

I've done quite a lot of LSD, and I feel that I have some anecdotal input that might be valuable to some. First, some background regarding my usage:

I've been using hallucinogenic substances for about 20 years (I was sixteen when I had my first LSD trip); at this point in my life, I like to have about four solid trips per year. In total, I've had around 200-250 trips on various drugs. At one point, I was doing mushrooms so frequently that they essentially stopped working (there was a week during college when I dosed on high-grade cubensis mushrooms eight times - by the end of the week, it took a full ounce before I could feel any effect). I've done most of the 2C drugs, DMT, ketamine, and every drug about which you've ever seen a cautionary after-school special. I've micro-dosed on LSD, and I've thumb-printed raw crystal. I've had multiple "level five" experiences. I've worked in tech for years, at companies that you've heard of.

First off: please be aware that hallucinogens are very powerful drugs, and they should never be taken lightly - I make no pretense of being a role-model. I knew a man who was absolutely addicted to LSD (he tripped every day, give or take since the early sixties - during the time that I knew him, he had a week or so when he couldn't trip, and he was truly frightening to be around sober. If you've ever seen anyone go off of anti-psychotics cold-turkey after prolonged usage, it was similar.)

That said, I believe that hallucinogens, and particularly LSD, have profoundly improved my life. The shift in perspective has helped me to defuse many emotional and psychological issues, and heightened my understanding of people, programming, and society as a whole.

To the person who wonders if they are too old to try LSD, I think you most likely are not. Most people who I have seen lose their shit on hallucinogens had it happen in their 20's - if you've made it to 30 without issues with psychosis, you're most likely in the clear.

All first time users should have their first experience in a comfortable setting, ideally with an experienced guide. I think it's tragic that modern society has all but eliminated the role of a shaman - it is very helpful to have someone who has walked the path before you show you the way.

One point that I would like to emphasize is that you shouldn't do hallucinogens to have fun. The experience is, of course, very frequently enjoyable, but these experiences should not be taken lightly. Personally, I believe that there is no such thing as a "bad trip". Some trips are challenging, and unpleasant, but if they are viewed with the proper perspective, they are still useful. Indeed, I have purposely taken trips in unpleasant circumstances in order to help me transcend various issues (again, if you have pre-existing psychosis, or are under ~25 years old, a trip might trigger some underlying issues).

If you're curious, and reasonably stable, I strongly recommend that you give it a try. LSD is the safest option - be wary of "designer" drugs, which can have much more dangerous side effects. As in all things, research is your friend, do some reading on erowid.org before you try any new drug. Be wary of LSD look-alikes, namely 25-I, which is increasingly common these days.

This is obviously a throw-away account, but I'll try to respond to any questions or comments tomorrow (GMT+8).

Re: Albert Hofmann discovers the effects of LSD (1943)

#70
The comparison of lsd to overclocking a processor is a pretty good one. Someone I know describes the experience in a similar way: "In normal waking life, data comes into my brain in a singular stream. On lsd my brain feels like it has the ability to process more at once- more streams."

Interesting things happen with all this input. Sensations get mixed around and felt in odd ways. For instance synesthesia... You make hear colors, or see emotions.

Here's an article about LSDs effects on the brain: https://www.theguardian.com/science/2016/apr/11/lsd-impact-b...

Post reply on HN