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Why I’m Digging Deep Into Alzheimer’s

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11–20 of 192 posts

Re: Why I’m Digging Deep Into Alzheimer’s

#11
It's interesting to note that tetrahydrocannabinol and other compounds found in marijuana may reduce the amount of beta amyloid in the brain. Beta amyloid is commonly thought to cause Alzheimer's disease.

see: https://www.nature.com/articles/npjamd201612

Last I heard in the US, the Federal government was still making it difficult to run clinical trials for Alzheimer's using marijuana. I think any federally funded medical trial using marijuana needs to be approved by the DEA.

Re: Why I’m Digging Deep Into Alzheimer’s

#12
post #5

>Most of the major pharmaceutical companies continue to pursue the amyloid and tau pathways. Dementia Discovery Fund complements their work by supporting startups as they explore less mainstream approaches to treating dementia. That's very encouraging. Because what if it's something else?

The amyloid and tau pathways are our best hope of finding a simple solution, something we can reasonably fix with drugs.

If it's something else, then chances are good it'll be far harder to fix, perhaps even requiring genetic engineering or medical nanotechnology. Finding out is still valuable, of course...

Re: Why I’m Digging Deep Into Alzheimer’s

#13
post #8

Disable the shitty auto-pausing of youtube video on scroll by pasting this on the console: getEventListeners(document.getElementById('tgnbody')).scroll.forEach(function(el){document.getElementById('tgnbody').removeEventListener("scroll", el.listener)})

Thanks!

I'd love to have a browser extension which automatically augments shitty websites with community-sourced javascript snippets. E.g. you'd visit idk Forbes.com, and saw that the site is unusable b/c of some shitty undismissable paywall overlay. You "fix" the issue with a few lines of JS, and then upload it via the extension. After going through some kind of vetting/review, the extension will automatically fetch and run your JS fix for everyone who visits the site.

Re: Why I’m Digging Deep Into Alzheimer’s

#14
post #10

Cynical answer: "because I'm getting old" :) Whatever the reason, this has the potential of being life-changing for a lot of people. Would love to see more billionaires involved with this kind of initiative.

Would love to see more non-billionaires involved. You might not be far off on “he’s getting older”. When you’re younger, you don’t think about the impact of “old people” diseases. Hearing that a couple billion people will get Alzheimer’s is not nearly as impactful as seeing someone a little older than you with it.

Don't know about you but seeing my grandparents getting senile was enough to get me thinking (and fearing) "old people problems".

Re: Why I’m Digging Deep Into Alzheimer’s

#15

Cynical answer: "because I'm getting old" :) Whatever the reason, this has the potential of being life-changing for a lot of people. Would love to see more billionaires involved with this kind of initiative.

The reason doesn't really matter, this is still incredibly valuable work.

Death is terrible, and should be eradicated, but Alzheimer's is a few steps above that. There's nothing worse than seeing a loved one be slowly destroyed by that horrific disease, and I'm so glad there are people willing to work on it.

Re: Why I’m Digging Deep Into Alzheimer’s

#16

Cynical answer: "because I'm getting old" :) Whatever the reason, this has the potential of being life-changing for a lot of people. Would love to see more billionaires involved with this kind of initiative.

The reason doesn't really matter, this is still incredibly valuable work. Death is terrible, and should be eradicated, but Alzheimer's is a few steps above that. There's nothing worse than seeing a loved one be slowly destroyed by that horrific disease, and I'm so glad there are people willing to work on it.

"Death is terrible, and should be eradicated"

We are sensitive to death but it is the only mechanism I know that would control overconsumption of natural resources. If nobody dies, then we would deplete the resources in a few decades.

Re: Why I’m Digging Deep Into Alzheimer’s

#17
post #13
post #8

Disable the shitty auto-pausing of youtube video on scroll by pasting this on the console: getEventListeners(document.getElementById('tgnbody')).scroll.forEach(function(el){document.getElementById('tgnbody').removeEventListener("scroll", el.listener)})

Thanks! I'd love to have a browser extension which automatically augments shitty websites with community-sourced javascript snippets. E.g. you'd visit idk Forbes.com, and saw that the site is unusable b/c of some shitty undismissable paywall overlay. You "fix" the issue with a few lines of JS, and then upload it via the extension. After going through some kind of vetting/review, the extension will automatically fetch…

Wasn't Edge supposed to support shareable annotations? That's nearly code...

Re: Why I’m Digging Deep Into Alzheimer’s

#18

Earlier quoted context omitted.

The reason doesn't really matter, this is still incredibly valuable work. Death is terrible, and should be eradicated, but Alzheimer's is a few steps above that. There's nothing worse than seeing a loved one be slowly destroyed by that horrific disease, and I'm so glad there are people willing to work on it.

"Death is terrible, and should be eradicated" We are sensitive to death but it is the only mechanism I know that would control overconsumption of natural resources. If nobody dies, then we would deplete the resources in a few decades.

We have death and at the same time over-consumption, so the control is not working that well. Did you mean that it would effectively control the over-consumption if better implemented (with a higher rate)?

Re: Why I’m Digging Deep Into Alzheimer’s

#19
post #13
post #8

Disable the shitty auto-pausing of youtube video on scroll by pasting this on the console: getEventListeners(document.getElementById('tgnbody')).scroll.forEach(function(el){document.getElementById('tgnbody').removeEventListener("scroll", el.listener)})

Thanks! I'd love to have a browser extension which automatically augments shitty websites with community-sourced javascript snippets. E.g. you'd visit idk Forbes.com, and saw that the site is unusable b/c of some shitty undismissable paywall overlay. You "fix" the issue with a few lines of JS, and then upload it via the extension. After going through some kind of vetting/review, the extension will automatically fetch…

Grease Monkey?

Re: Why I’m Digging Deep Into Alzheimer’s

#20
It's great to see more investment into this disease.

When my grandma fought Alzheimer's over the span of a decade it was very striking to see that the effect of a lack of hydration and the disease itself kind of overlapped. When she had a particularly bad day we used to give her a saline IV and you could immediately notice how she cleared up and regained her brain powers after each IV.

I'm not up to date on current research into that direction, but I think hydration plays a very big role in Alzeimer's symptoms on the elderly.

I know it sounds ridiculous, but once I'm rich enough I want to build an elderly care center/hospital with urine-based hydration monitoring for each participant so family members can be sure that their loved ones have a healthy water intake each and every day.

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