Why I’m Digging Deep Into Alzheimer’s
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Why I’m Digging Deep Into Alzheimer’s
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Re: Why I’m Digging Deep Into Alzheimer’s
#2His first donation is $50 million to this private organization:
Re: Why I’m Digging Deep Into Alzheimer’s
#3The slow pace of progress towards clearance of amyloid, in that only in the past year has one of the immunotherapy trials actually looked promising, has provoked a lot of alternative theorizing these past five years. Some it is clearly not so great, such as the fellow who argues that it is caused by rising use of paracetamol (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921468/ ), but some lines of theory are much more compelling. A more encompassing synthesis is emerging in which microbial infection by spirochetes and gum disease bacteria (e.g. see https://doi.org/10.3389/fnagi.2017.00336 ) that can provoke amyloid formation as well as failing drainage of cerebrospinal fluid (e.g. see https://doi.org/10.1002/ana.24271, https://www.ethz.ch/en/news-and-events/eth-news/news/2017/11..., etc) that stops removal of amyloid, tau, etc are as important as purely cell focused considerations of the biochemistry of amyloid beta.
For an example of the new type of venture emerging now as a result of all of this you might look at Leucadia Therapeutics, working on a way to restore drainage through the cribiform plate, but there will be more in the years ahead to complement the immunotherapy for amyloid and tau mainstream.
Re: Why I’m Digging Deep Into Alzheimer’s
#4Re: Why I’m Digging Deep Into Alzheimer’s
#5>Most of the major pharmaceutical companies continue to pursue the amyloid and tau pathways. Dementia Discovery Fund complements their work by supporting startups as they explore less mainstream approaches to treating dementia.
That's very encouraging. Because what if it's something else?
Re: Why I’m Digging Deep Into Alzheimer’s
#6Cynical answer: "because I'm getting old" :)
Whatever the reason, this has the potential of being life-changing for a lot of people. Would love to see more billionaires involved with this kind of initiative.
Re: Why I’m Digging Deep Into Alzheimer’s
#7The slow pace of progress towards clearance of amyloid, in that only in the past year has one of the immunotherapy trials actually looked promising, has provoked a lot of alternative theorizing these past five years. Some it is clearly not so great, such as the fellow who argues that it is caused by rising use of paracetamol (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921468/ ), but some lines of theory are muc…
>> A more encompassing synthesis is emerging in which microbial infection by spirochetes and gum disease bacteria
Wow, I did "notice" a strong correlation between gum disease and dementia in my own Family. This is obviously my own uneducated guess but it's humbling to see serious people looking into it! There very well could be some sort of dementia that is indeed related to gum disease!
Re: Why I’m Digging Deep Into Alzheimer’s
#8Disable the shitty auto-pausing of youtube video on scroll by pasting this on the console:
getEventListeners(document.getElementById('tgnbody')).scroll.forEach(function(el){document.getElementById('tgnbody').removeEventListener("scroll", el.listener)})Re: Why I’m Digging Deep Into Alzheimer’s
#9The slow pace of progress towards clearance of amyloid, in that only in the past year has one of the immunotherapy trials actually looked promising, has provoked a lot of alternative theorizing these past five years. Some it is clearly not so great, such as the fellow who argues that it is caused by rising use of paracetamol (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921468/ ), but some lines of theory are muc…
>> A more encompassing synthesis is emerging in which microbial infection by spirochetes and gum disease bacteria Wow, I did "notice" a strong correlation between gum disease and dementia in my own Family. This is obviously my own uneducated guess but it's humbling to see serious people looking into it! There very well could be some sort of dementia that is indeed related to gum disease!
I believe gum disease is also correlated with cardiovascular disease.
Re: Why I’m Digging Deep Into Alzheimer’s
#10Cynical answer: "because I'm getting old" :) Whatever the reason, this has the potential of being life-changing for a lot of people. Would love to see more billionaires involved with this kind of initiative.
Would love to see more non-billionaires involved.
You might not be far off on “he’s getting older”. When you’re younger, you don’t think about the impact of “old people” diseases.
Hearing that a couple billion people will get Alzheimer’s is not nearly as impactful as seeing someone a little older than you with it.