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Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

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Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#61

Earlier quoted context omitted.

Alcohol: Anxiety disorders Marijuana: OCD Caffeine: ADHD

Or just MJ for everything

My thought as well, but it's worth it to keep in mind young people probably shouldnt, along with those predisposed to schizophrenia and similar disorders, though I suspect certain strains or alternative cannabanoids out of the hundreds in addition to thc/cbd might be useful.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#62
post #38

Tangential self experimentation anecdote: I was intrigued by reports that nicotine can improve cognition in otherwise healthy people so I read through as many studies/articles I could find online. After deciding that I'd done enough research I took the plunge and began self experimenting with 2mg gum. I took it daily throughout the day at regular-ish intervals for around 2-3 months. The affects I experienced were as…

Why not just get more, higher quality sleep? It provides all of the upsides that you mention with no downsides.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#63
post #25

This makes me wonder what the modern world would look like if all "recreational drugs" suddenly disappeared, and so all the people who were implicitly, unknowingly self-medicating for a mental illness by using recreational drugs, suddenly weren't. What percentage of the population would go from seemingly neurotypical, to perceivably mentally ill? How much more common would conditions like schizophrenia be?

The effect on the underlying conditions are relatively small - otherwise we would have noticed that nicotine is a cure for schizophrenia. So the addicted will get slightly improvements from their drug. Some of them enough to reduce their chance of a clinical diagnosis. Most people won't be close enough to (the very blurry) line to swap between diagnosed and subclinical.

Well we might have noticed it a lot earlier if psychiatrists did a better job of listening to their patients instead of scribbling a prescription and telling them to come back in 3 months. My last psychiatrist is regarded as one of the leading researchers in his sub-specialty and did very little to earn the $500/hour I was paying him.

Your comment assumes the psychiatric profession is generally meretricious and evidence-driven. Many psychiatric patients' experience suggests otherwise.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#64

“This defines a completely novel strategy for medication development,” says lead author As someone with schizoaffective problems and raging ADHD, I find quotes like this acutely annoying. I've told every psychiatrist I'eve ever dealt with about the experiential costs/benefits of smoking (and consuming various other recreational drugs). They all nod sagely and say things like 'but smoking is bad' (no shit Sherlock!) w…

Fascinating story. Sorry it has become tougher since quitting--a near Sophie's Choice predicament.

I find M.D.'s to be alarmingly low in intellectual curiosity.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#65
post #38

Tangential self experimentation anecdote: I was intrigued by reports that nicotine can improve cognition in otherwise healthy people so I read through as many studies/articles I could find online. After deciding that I'd done enough research I took the plunge and began self experimenting with 2mg gum. I took it daily throughout the day at regular-ish intervals for around 2-3 months. The affects I experienced were as…

>The real problem would happen if I was under stress, my BP would spike to dangerous levels when it never had done before. I also felt that I would get stressed more easily.

That's pretty characteristic of out-of-control blood pressure.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#66

Earlier quoted context omitted.

Clarifying: Nicotine harms everyone. Net harm to a schizophrenic may be negative, but they are still harmed. "Self-medication hypotheses" exist for many abused substances. Rather than accusing the addicted of poor education, self control, or intelligence it argues (with mounting evidence) that there is a structural or genetic issue that contributes for some addictions. Ideally we would figure out the mechanism of act…

Bullshit. Nicotine in itself doesn't harm anyone, that's completely made up. On the contrary, a lot of people would be helped by getting more Nicotine into their system, preferably from eating veggies rather than smoking it.

The burden of proof is on you here. If you're going to argue something at odds with the medical profession and most published research, you better have some solid facts from reliable sources.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#67
post #38

Tangential self experimentation anecdote: I was intrigued by reports that nicotine can improve cognition in otherwise healthy people so I read through as many studies/articles I could find online. After deciding that I'd done enough research I took the plunge and began self experimenting with 2mg gum. I took it daily throughout the day at regular-ish intervals for around 2-3 months. The affects I experienced were as…

And this is why vaping should be banned in enclosed public spaces, especially offices.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#68
I'm convinced that if it were suddenly discovered today, nicotine would be hailed as a miracle drug.

It has several properties. It's both a stimulant and a relaxant. It helps you focus without burning out your neurons and inducing psychosis like amphetamines.

https://en.wikipedia.org/wiki/Nicotine#Psychoactive_effects

https://en.wikipedia.org/wiki/Nicotine#Enhancing_performance

While there is some risk to it, the actual danger (cancer, heart attack, stroke) from smoking is due to the tar content and other products of combustion from burning tobacco. While nicotine doesn't help blood pressure, it's not the killer that smoking is. It's also somewhat carcinogenic -- again, not as much as tobacco smoke and tar itself. You can find 80 and 90 year old smoking, but you can't really find elderly using cocaine, for example. As far as drugs go, it's relatively safe, for the benefits that it provides.

Also, there are several MAOIs in tobacco smoke. MAOIs are used as last-line anti-depressants, because of their side-effects when taken in large doses. But with tobacco products, a user basically gets a tritrateable MAOI.

If we suddenly discovered nicotine today, I'm convinced that either it or a close chemical cousin would be a the next miracle drug for anxiety and depression.

Perhaps there is a molecular relative of nicotine that could be employed as such, perhaps with less side-effects.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#69
post #62
post #38

Tangential self experimentation anecdote: I was intrigued by reports that nicotine can improve cognition in otherwise healthy people so I read through as many studies/articles I could find online. After deciding that I'd done enough research I took the plunge and began self experimenting with 2mg gum. I took it daily throughout the day at regular-ish intervals for around 2-3 months. The affects I experienced were as…

Why not just get more, higher quality sleep? It provides all of the upsides that you mention with no downsides.

Not parent, but nothing I have tried improves my sleep. Baseline is just bad. Exercise, meditation, alarms – nothing works. The only thing that raised the baseline was quitting caffeine.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#70

That Schizophrenia patients smoke a lot is well known. I guess this explains it. The other weird Schizophrenia fact is that blind people are never Schizophrenic. Congenital Blindness, that is. Poking your eyes out won't cure Schizophrenia once you have it.

> blind people are never Schizophrenic

That is an interesting observation. Do you have a source?

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