Live data from Hacker News

Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

neurosciencenews.com

21–30 of 246 posts

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#21

That Schizophrenia patients smoke a lot is well known. I guess this explains it. The other weird Schizophrenia fact is that blind people are never Schizophrenic. Congenital Blindness, that is. Poking your eyes out won't cure Schizophrenia once you have it.

But how about poking your visual cortex out?

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#22

Earlier quoted context omitted.

Well, its the same thing in prisons, so I always assumed its boredom/stress relief as the explanation for chain smoking.

Or it indicates that prisons also contain many mentally ill inmates...

Which they do, but it is really tough to unwind the correlation/causation factors here.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#23
post #19

It won't really be a surprise, when science learns that most "harmful addictive" substances can improve aspects of brain function for many people.

Isn't it more the delivery mechanism than the drug itself?

Away with your nuances, we must stay 'on message' and the message is 'psychoactive substances are always bad'. :P

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#24
post #9

Can anyone with access to the paper give a few technical details? The abstract mentions "Chronic nicotine administration" does this mean the nicotine dosage is high enough to not be a viable basis for treatment? The linked article claims that this could be a basis for new drug research, which sounds exciting, but how much do we already know about drugs that affect the nicotinic receptors?

Try to look up this article(by doi) on sci-hub.cc

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#25
This makes me wonder what the modern world would look like if all "recreational drugs" suddenly disappeared, and so all the people who were implicitly, unknowingly self-medicating for a mental illness by using recreational drugs, suddenly weren't. What percentage of the population would go from seemingly neurotypical, to perceivably mentally ill? How much more common would conditions like schizophrenia be?

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#26
post #19

It won't really be a surprise, when science learns that most "harmful addictive" substances can improve aspects of brain function for many people.

Isn't it more the delivery mechanism than the drug itself?

After lung disease, the second largest consequence of tobacco smoking is heart disease, which is due to the nicotine itself.

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#28

For those who have seen severe mental illness up close, this is not surprising in the least. Many, many people with schizophrenia or other disorders characterized by psychosis self-medicate heavily with cigarettes. Huddled masses of patients smoking outside are fixtures of most psychiatric treatment facilities.

The same applies to office buildings

Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia

#30
post #5

Original DOI link: http://dx.doi.org/10.1038/nm.4274 Edit: Please read abandonliberty's comment below before reading mine. I didn't properly elucidate the position on the harms v. benefits tradeoff (net harm) the way abandonliberty did. My own opinion: it wouldn't be terribly surprising to see many harmful substances only be harmful to a majority subset of a population space, though that's why the scheduling system (…

Unfortunately drug schedules aren't evidence based, and there's no evidence based measurement for "potential for abuse" in use by the DEA or FDA.

[deleted]
Post reply on HN