I've always thought the 'living in a simulation' scenario and creationism are pretty much the same thing, if the person that started the simulation felt some sort of rules ought to be followed (for the longevity of the simulation, or whatever reason they might have). That doesn't seem like a stretch - we do that with the Sim games, and we're hardly brilliant.
If we are living in a simulation, it is a simulation of atoms, or quantum fields, or perhaps something deeper behind that. That got started with enormous energy in the form of hot dense quark gluon plasma. From there the rest follows. It is not a simulation of humans. We have zero indication there are rules at a higher level than the quantum or gravity. Like rules on what you ought to do in the bedroom. Also earth no…
There is no difference.