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This is especially interesting, since coffee is moderately protective for Parkinson's. Does that mean the coffee may be working at the gut level rather than its caffeine working in the brain? On second thought, coffee definitely works on the gut in normal people, if you know what I mean.
I remember reading that study too but I think coffee was only shown to be significantly protective for 8-10+ cups/day.
What do we know so far? - Gut Bacteria are involved - Inflammation is involved - The brain works on glucose - The brain can also work on Ketones - Cinnamon seems to help in mice trials (and also has anti-inflammatory properties). - Could diabetes be analogous to Parkinson's? Diabetics generally have lost the ability to process carbs (usually by eating too many); could Parkinsons be caused by people being very dopamin…
This is very wrong, but the stuff in the parenthesis is even more so.
Please do not mix type 1 and type 2 diabetes. While it could be argued that type 2 is improved by diet, the amount of carbs eaten by type 1 diabetics is completely and utterly irrelevant, there's no correlation between that and them developing the disease.
Source: diabetic brother from an early age.
> could Parkinsons be caused by people being very dopamine focused and wearing their brains out?
Unlikely. I have not seen any indications that dopamine is involved in any Parkinson mechanism at all.
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Adding to this, dementia might be a "side" effect of the medication for the muscles' rigidity. It's hard to explain but eventually there comes a time when you need to opt between not being able to move or take the medication and start having more and more frequent surreal visions. My grandfather survived a few cancer appearances but during the last surgery to remove some cancer lumps he woke up as a completely new pe…
> He was pretty "normal" before the surgery but after it he couldn't walk and thought the hospital staff attacked him with dogs during the night. Apparently delirium is a common side effect of whatever they do in hospitals. I came across this link last month: "Delirium: A Surprising Side Effect of Hospital Stays -- Often misdiagnosed as dementia, it can cause hallucinations and delusions" - http://www.nextavenue.org/…
However, I'd personal take the intermittent low level psychosis any day if it meant retaining my brain, retaining 'me', for just a bit longer.
Also yeah, as stated elsewhere: Parkinson's + anti-psychotic meds == dangerous and egregious medical malpractice. Anti-psychotics are basically an anti-cute for Parkinson's, given the generally work by attenuating dopamine prevalence in various synaptic clefts.
My Dad was recently diagnosed. Very early stage. This is very interesting news. My take is that Parkinson's is a little like cancer in that it likely has multiple root causes that can injure the same part of the brain (substantia niagra) and cause the disease. My research for his case led me to vitamin k2 deficiency as a possible cause / complicating factor. There are some genetic models and mouse trials that show k2…
I'm obviously not a doctor and don't know, but from what I saw, he barely shook at all. He swore that when he went off his diet he would start shaking again. He also said his doctor couldn't believe how well he did on his own.
He said it all started from this book: http://brainhealthbook.com/why-isnt-my-brain-working
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Short chain fatty acids can be things like acetic acid, propionic acid, butyric acid. The fermentation process takes in fiber and puts out these guys, so while fiber isn't an SCFA polymer, I don't think this statement is inaccurate (i.e. I don't have the metabolic pathways off hand but these could be direct breakdown products given the shortness of the carbon chains - acetic acid almost certainly is.)
I mostly agree. The main path for glucose involves splitting it in two 3 carbon molecules, mainly pyruvate https://en.wikipedia.org/wiki/Glycolysis From this it's easy to make acetic acid (2 carbons), like the acetic acid in vinegar. And , I guess it's also not very difficult to make propionic acid (3 carbons). I can accept that they say that fiber or glucose is "break down" to acetic acid, propionic acid, but I thin…
Another common way some AAs are metabolised is by hydrogenation is red blood cells. So I think this eats up a hydrogen ion at the very least, leading to greater intra-cellular oxidisation and a messed up blood plasma pH, increasing the occurrence of abnormal enzymatic reactions. The metabolites you mentioned are present in much larger quantities on low carbs, due to increased synthesis and use of proteins for energy, including for the brain...
Oh and at least a few of those metabolites sometimes ultimately metabolise to acetone, especially if normal metabolism disrupted by wonky pH balance.
Anion gap in soft tissue cells may also explain 'twitches': spontaneous muscular activation due to soft tissue cell hyper-natremia (unbalanced towards sodium).
Crazily, excess acetone restoration is one theory that explains spontaneous human combustion (acetone is quite volatile and flammable)...
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I mostly agree. The main path for glucose involves splitting it in two 3 carbon molecules, mainly pyruvate https://en.wikipedia.org/wiki/Glycolysis From this it's easy to make acetic acid (2 carbons), like the acetic acid in vinegar. And , I guess it's also not very difficult to make propionic acid (3 carbons). I can accept that they say that fiber or glucose is "break down" to acetic acid, propionic acid, but I thin…
I think this is the crux of the issue. If one ascribed to the prion hypothesis, than ketogenic metabolism would almost certainly have to be related to higher probability of prion formation, and more survivable conditions in vivo. Another common way some AAs are metabolised is by hydrogenation is red blood cells. So I think this eats up a hydrogen ion at the very least, leading to greater intra-cellular oxidisation an…
My Dad was recently diagnosed. Very early stage. This is very interesting news. My take is that Parkinson's is a little like cancer in that it likely has multiple root causes that can injure the same part of the brain (substantia niagra) and cause the disease. My research for his case led me to vitamin k2 deficiency as a possible cause / complicating factor. There are some genetic models and mouse trials that show k2…
I worked with a guy who has Parkinson's. He was _obsessed_ with nutrition and always said the same thing about it being related to his gut. I don't think I've ever seen someone eat as natural and health as this guy. I'm obviously not a doctor and don't know, but from what I saw, he barely shook at all. He swore that when he went off his diet he would start shaking again. He also said his doctor couldn't believe how w…
There is related work on dementia as well, wish I could find it. Something to do with increasing dietary ketones (using oils) to make up for glucose processing issues in people who were long term pre-diabetic. It was a dinner conversation, where a guy was reasoning that some degenerative and autoimmune diseases were related to tissue starvation as a result of inhibited glucose processing, and he was using ketones (wi…
And there might be a runaway/tipping point somewhere here: some amino acids have acidic metabolites and also need to capture hydrogen ions from red blood cells to metabolise/synthesise protein. Some of these metabolites also cause acetone build up in body, which starts to be expelled via lungs.
So combo of high rates of protein synthesis, abnormal blood plasma pH balance and increases cell oxidisation and anion gap == greater rate of prion formation and survival.
This is just a personal hypothesis, no real evidence to back it up. Just suggesting caution should be exercised here. PD is a horrible disease, I wouldn't wish it on my worst enemy.
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I'm not sure if it has differentiation, but lifestyle factors could have an impact. If, for example, in more developed countries there's a great emphasis on (especially) childhood cleanliness, it may be affecting the development of "good" bacteria: http://www.bbc.com/future/story/20151118-can-you-be-too-clea... Another lifestyle example could be the prevalence of C-section births in more developed countries: https://…
From the map I linked above, developed countries seem to have high rates. Parkinson's doesn't seem to discriminate there, so is there any other thing interesting by country? Spurious and sounds silly, but spicy foods, maybe?
I watched my great grandfather lose everything to Parkinson's. I really hope this leads to a treatment that stops the progression of symptoms and fast.
it seems that it is just one among several paths to Parkinson's. Not being a doctor, just from googling, it seems that Parkinson's - specifically those protein clumps in the brain cells - is a result of inflammation, ie. immune system reaction. Some gut bacteria (or its by-product), as in this study, seems to be a trigger for such reaction. Looking into the spread of Parkinson's around the world - many places/localitites with high rates are completely different from each other - confirms to me that there are possibly many different triggers for such immune system reaction, one of them seems to be pesticides for example.