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Parkinson’s disease ‘may start in gut’

bbc.co.uk

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Re: Parkinson’s disease ‘may start in gut’

#71

Post by paulcole »

andy_ppp wrote: post #8

What do we know so far? - Gut Bacteria are involved - Inflammation is involved - The brain works on glucose - The brain can also work on Ketones - Cinnamon seems to help in mice trials (and also has anti-inflammatory properties). - Could diabetes be analogous to Parkinson's? Diabetics generally have lost the ability to process carbs (usually by eating too many); could Parkinsons be caused by people being very dopamin…

>Diabetics generally have lost the ability to process carbs (usually by eating too many)

Impressively wrong

Re: Parkinson’s disease ‘may start in gut’

#72

Post by amelius »

sgt101 wrote: post #46
apinstein wrote: post #33

My Dad was recently diagnosed. Very early stage. This is very interesting news. My take is that Parkinson's is a little like cancer in that it likely has multiple root causes that can injure the same part of the brain (substantia niagra) and cause the disease. My research for his case led me to vitamin k2 deficiency as a possible cause / complicating factor. There are some genetic models and mouse trials that show k2…

My father has Parkinson's and has severe osteoporosis, I wonder if there is a connection.

It could be the case. But in order to find out, the best way would be to correlate both conditions with medical reports of a large number of patients.

A platform like [1] could help in sorting this out.

(Question: Does anybody know other/better platforms for this purpose? Does anybody have positive experience in doing this kind of research using such platform?)

[1] http://patientslikeme.com

Re: Parkinson’s disease ‘may start in gut’

#73

Post by paulcole »

andy_ppp wrote: post #56
pascalmemories wrote: post #51

Earlier quoted context omitted.

> Diabetics generally have lost the ability to process carbs (usually by eating too many) That's an outrageous misrepresentation of diabetes ( all types). Diabetics process carbs exactly like everyone else. The body breaks them down and throws the sugars into the bloodstream in the perfectly normal way. The lack of insulin (generally Type 1) or the resistance to insulin present (generally Type 2), means the cells str…

I'm sorry for upsetting you but from my research eating high sugar/carb diets (without exercise) causes insulin resistance in the majority of people. There are some groups that are more susceptible to this of course. I'm not blaming anyone or even thinking about that; I've just done a lot of research and listened to a lot of interesting studies about the gut biome, western diet, insulin resistance, weight training, H…

>Maybe I'll be proved to be wrong

That day has come

http://goaskalice.columbia.edu/answered-questions/it-true-ea...

Re: Parkinson’s disease ‘may start in gut’

#74

Post by kmonad »

fibbra wrote: post #29

There is need for research into what is happening in the gut, what the microbiome looks like and how it is influenced by food and stress. This research money can either come by government funding (ideal for basic research) or by private funding (focused, to produce top medicines). As it looks now, the private funding may not work because any remedy in the form of a medicine, would be applied a couple of times and tha…

And there is, tons of it. Though I do agree that private investments need to find a niche beyond yoghurts.

https://www.broadinstitute.org/hmp/human-microbiome-project https://www.mskcc.org/research-areas/topics/microbiome-infla... http://humanfoodproject.com/americangut/

Re: Parkinson’s disease ‘may start in gut’

#75

Post by binarymax »

simonh wrote: post #6
ianai wrote: post #2

I watched my great grandfather lose everything to Parkinson's. I really hope this leads to a treatment that stops the progression of symptoms and fast.

My father suffered from the disease and passed away in October. Awful disease. This is great news, but it looks like any treatment based on this will still be quite some way off.

I am so sorry for your loss. My uncle passed away from Parkinsons 20 years ago, when he was fully incapacitated and incapable of doing anything. As difficult as it is to witness, I cannot imagine the pain of the experience.

Re: Parkinson’s disease ‘may start in gut’

#77

Post by illumin8 »

tcj_phx wrote: post #64
iaskwhy wrote: post #26

Earlier quoted context omitted.

Adding to this, dementia might be a "side" effect of the medication for the muscles' rigidity. It's hard to explain but eventually there comes a time when you need to opt between not being able to move or take the medication and start having more and more frequent surreal visions. My grandfather survived a few cancer appearances but during the last surgery to remove some cancer lumps he woke up as a completely new pe…

> He was pretty "normal" before the surgery but after it he couldn't walk and thought the hospital staff attacked him with dogs during the night. Apparently delirium is a common side effect of whatever they do in hospitals. I came across this link last month: "Delirium: A Surprising Side Effect of Hospital Stays -- Often misdiagnosed as dementia, it can cause hallucinations and delusions" - http://www.nextavenue.org/…

Out of curiosity, how does coconut oil help with "delirium"?

Re: Parkinson’s disease ‘may start in gut’

#78

Post by zdean »

laypersonjoe wrote: post #76

By country. Does gut bacteria have differentiation by region/country/diet and by extension can some diets be less causative? http://www.worldlifeexpectancy.com/cause-of-death/parkinson-...

I'm not sure if it has differentiation, but lifestyle factors could have an impact. If, for example, in more developed countries there's a great emphasis on (especially) childhood cleanliness, it may be affecting the development of "good" bacteria:

http://www.bbc.com/future/story/20151118-can-you-be-too-clea...

Another lifestyle example could be the prevalence of C-section births in more developed countries:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110651/

Re: Parkinson’s disease ‘may start in gut’

#80

Post by WorldMaker »

amelius wrote: post #72
sgt101 wrote: post #46

Earlier quoted context omitted.

My father has Parkinson's and has severe osteoporosis, I wonder if there is a connection.

It could be the case. But in order to find out, the best way would be to correlate both conditions with medical reports of a large number of patients. A platform like [1] could help in sorting this out. (Question: Does anybody know other/better platforms for this purpose? Does anybody have positive experience in doing this kind of research using such platform?) [1] http://patientslikeme.com

The best platforms for this sort of research in the US are internal proprietary toolkits of health insurance companies, auditing companies, and law firms. The profit motives of the US health care system don't currently incentivize putting these platforms to use for science, they are mostly used for (re-) billing.

(Source: Worked for an auditing/law firm company deep on their platform once. Have friends still in health insurance/auditing/law firms.)

As for an anecdotal positive experience, one of my friends working for a health insurance company did find a correlation in lack of remissions of a very specific form of cancer and the use of a prescription drug by datamining health insurance records and helped publish that as a cure for that very specific cancer.

But given the way the industries are incentivized and fight among each other and fail to cooperate, I fear I have plenty more negative anecdotes than positive ones of things researched on top of these walled garden platforms.

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