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Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

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21–30 of 36 posts

Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

#21
post #12

If you don't understand that correlation doesn't imply causation, you should be sent back to your first year of high school and forced to try it all again.

What, if not correlation, does imply causation?

I'm sorry, is that an incredibly lazy way of arguing that correlation does imply causation, but you feel like reversing it and dumping the burden of proof onto me?

No.

Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

#22
post #6

The problem really lies with the fact that within the more than 100,000 published studies on Alzheimer's disease you are bound to find a random association between this disease and many other things. This is especially true for observational studies in people, and also true for low-powered studies in experimental animals. Experimental science, however, demands that one establishes a cause and effect relationship. The…

There is a known cure for early Alzheimer's. https://www.aging-us.com/article/9R5JsRe8k4Jq7uTXj/text

Bredesen DE. Reversal of cognitive decline in Alzheimer's disease. Aging (Albany NY). 2016 Jun;8(6):1250-8. doi: 10.18632/aging.100981.

Bredesen DE. Reversal of cognitive decline: A novel therapeutic program. Aging (Albany NY). 2014; 6:707-17. doi: 10.18632/aging.100690.

Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

#23
post #6

The problem really lies with the fact that within the more than 100,000 published studies on Alzheimer's disease you are bound to find a random association between this disease and many other things. This is especially true for observational studies in people, and also true for low-powered studies in experimental animals. Experimental science, however, demands that one establishes a cause and effect relationship. The…

[deleted]

Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

#24
post #6

The problem really lies with the fact that within the more than 100,000 published studies on Alzheimer's disease you are bound to find a random association between this disease and many other things. This is especially true for observational studies in people, and also true for low-powered studies in experimental animals. Experimental science, however, demands that one establishes a cause and effect relationship. The…

Why do you doubt that it is (or can be) caused by infectious agents, aside from the fact that in science doubt should be the default position. Is there evidence against it?

My intuition is that it is more likely caused by an infection than that it is just a malfunction caused by random chance

Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

#26

I read, with great hope, every Alzheimer's breakthrough but in the last year alone the key has been found out to be: 1. Exercise for oxygen 2. Gum disease 3. Standing up and feeling a head rush 4. blood sugar and diabetes If we can believe each of these 4 is the key insight within 12 months, I have to wonder at the state of our knowledge about the disease.

I've read that we aren't even 100% sure that the beta-amaloyde (spelling?) plaque, which is so associated with the disease, might not even be a cause but just a side effect (or even a protecting agent in defense of the disease).

Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

#27
post #6

The problem really lies with the fact that within the more than 100,000 published studies on Alzheimer's disease you are bound to find a random association between this disease and many other things. This is especially true for observational studies in people, and also true for low-powered studies in experimental animals. Experimental science, however, demands that one establishes a cause and effect relationship. The…

There is a known cure for early Alzheimer's. https://www.aging-us.com/article/9R5JsRe8k4Jq7uTXj/text Bredesen DE. Reversal of cognitive decline in Alzheimer's disease. Aging (Albany NY). 2016 Jun;8(6):1250-8. doi: 10.18632/aging.100981. Bredesen DE. Reversal of cognitive decline: A novel therapeutic program. Aging (Albany NY). 2014; 6:707-17. doi: 10.18632/aging.100690.

Fascinating, thanks for the links. These findings might be preliminary, as this criticism of the claims lays out the case that it might be premature to make such assertions this early.

https://www.sciencebasedmedicine.org/mend-protocol-for-alzhe...

The commercialization of the MEND protocol might have run into some partnership issues between the original researcher and the first company he worked with dispensing the treatment:

http://www.prnewswire.com/news-releases/dr-dale-bredesen-ann...

Here is a more layman-friendly description of the MEND protocol.

http://bottomlineinc.com/alzheimers-symptoms-reversed/

Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

#28
post #6

The problem really lies with the fact that within the more than 100,000 published studies on Alzheimer's disease you are bound to find a random association between this disease and many other things. This is especially true for observational studies in people, and also true for low-powered studies in experimental animals. Experimental science, however, demands that one establishes a cause and effect relationship. The…

There is a known cure for early Alzheimer's. https://www.aging-us.com/article/9R5JsRe8k4Jq7uTXj/text Bredesen DE. Reversal of cognitive decline in Alzheimer's disease. Aging (Albany NY). 2016 Jun;8(6):1250-8. doi: 10.18632/aging.100981. Bredesen DE. Reversal of cognitive decline: A novel therapeutic program. Aging (Albany NY). 2014; 6:707-17. doi: 10.18632/aging.100690.

>Here we report the results from quantitative MRI and neuropsychological testing in ten patients with cognitive decline, nine ApoE4+ (five homozygous and four heterozygous) and one ApoE4-, who were treated with the MEND protocol for 5-24 months.

The number of patients studied is too few, i.e. is grossly underpowered statistically, and the results do not allow any general conclusion to be drawn.

Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

#29
post #24
post #6

The problem really lies with the fact that within the more than 100,000 published studies on Alzheimer's disease you are bound to find a random association between this disease and many other things. This is especially true for observational studies in people, and also true for low-powered studies in experimental animals. Experimental science, however, demands that one establishes a cause and effect relationship. The…

Why do you doubt that it is (or can be) caused by infectious agents, aside from the fact that in science doubt should be the default position. Is there evidence against it? My intuition is that it is more likely caused by an infection than that it is just a malfunction caused by random chance

I doubt it because if it were caused by an infection, one would expect infections to cause Alzheimer's disease-like conditions more generally.

If it is caused by a specific infection, then one would expect such a specific infection to cause the disease in young as well as older people.

Neither of these scenarios are known to occur.

If you extend beyond these simple scenarios, then you have to assume that there is another (unknown) factor that induces Alzheimer's disease, and therefore that the theory of infectious disease causing this condition is not sufficient.

Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

#30
post #29
post #24

Earlier quoted context omitted.

Why do you doubt that it is (or can be) caused by infectious agents, aside from the fact that in science doubt should be the default position. Is there evidence against it? My intuition is that it is more likely caused by an infection than that it is just a malfunction caused by random chance

I doubt it because if it were caused by an infection, one would expect infections to cause Alzheimer's disease-like conditions more generally. If it is caused by a specific infection, then one would expect such a specific infection to cause the disease in young as well as older people. Neither of these scenarios are known to occur. If you extend beyond these simple scenarios, then you have to assume that there is ano…

Suppose it is a reaction to a viral infection you get when you are young which reactivates when you get older. It could even be that the initial infection is asymptomatic in many or most people and that only a small percentage of those infected ever get the later reaction. It could be one specific virus or it could be that several virus can do it. It could be dependent on some other factor such as how the virus integrates into the host genome or later immunosuppression.
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