Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
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Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
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Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
#2From the abstract towards the bottom of the page:
> We refer to the many studies, mainly on humans, implicating specific microbes in the elderly brain, notably herpes simplex virus type 1 (HSV1), Chlamydia pneumoniae, and several types of spirochaete, in the etiology of AD.
Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
#3This is from March. Any critiques published?
Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
#4You probably have herpes but that's okay: https://www.washingtonpost.com/news/speaking-of-science/wp/2...
My wife studies Alzheimer's and I hope she will respond here, but I'm afraid she gets too angry by sensationalist stories based on editorials rather than mainline research.
Of course there is inflammation involved. From what I understand talking with her, there is not much mechanistic work done with human tissue; most of it is with mouse models that can only get parts of the disease.
Interesting to check out: the inflammasome: https://en.m.wikipedia.org/wiki/Inflammasome.
Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
#5You probably have herpes but that's okay: https://www.washingtonpost.com/news/speaking-of-science/wp/2... My wife studies Alzheimer's and I hope she will respond here, but I'm afraid she gets too angry by sensationalist stories based on editorials rather than mainline research. Of course there is inflammation involved. From what I understand talking with her, there is not much mechanistic work done with human tissue;…
Plus it's hard to take the researcher seriously when it looks like they created their own university.
"Professor Resia Pretorius of the University of Pretoria"
Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
#6The problem really lies with the fact that within the more than 100,000 published studies on Alzheimer's disease you are bound to find a random association between this disease and many other things. This is especially true for observational studies in people, and also true for low-powered studies in experimental animals.
Experimental science, however, demands that one establishes a cause and effect relationship. There is no known cure of Alzheimer's disease, so one cannot refer to experimental medicine for an answer, with the exception of inherited dominant genetic mutations that impact only a small number of people. Unfortunately, of these mutations, those affecting the APP gene do not cause neuronal loss in mice; so the mouse models are inherently problematic.
This editorial calls for a clinical trial for antimicrobials in this disease. While I doubt that Alzheimer's is caused by infectious agents, there really is no harm in trying (except perhaps to the pockets of the trial's sponsors). In fact a trial of the antibiotic minocycline was completed in 2014 [1], however the results do not appear to have been reported.
Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
#7You probably have herpes but that's okay: https://www.washingtonpost.com/news/speaking-of-science/wp/2... My wife studies Alzheimer's and I hope she will respond here, but I'm afraid she gets too angry by sensationalist stories based on editorials rather than mainline research. Of course there is inflammation involved. From what I understand talking with her, there is not much mechanistic work done with human tissue;…
Plus it's hard to take the researcher seriously when it looks like they created their own university. "Professor Resia Pretorius of the University of Pretoria"
> Pretoria: Capital of South Africa
founding a city to start your own University sixty years later to publish a paper another hundred years later, that's what I call the long-con.
Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
#8The problem really lies with the fact that within the more than 100,000 published studies on Alzheimer's disease you are bound to find a random association between this disease and many other things. This is especially true for observational studies in people, and also true for low-powered studies in experimental animals. Experimental science, however, demands that one establishes a cause and effect relationship. The…
Often negative results are never published. Great post.
Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
#9You probably have herpes but that's okay: https://www.washingtonpost.com/news/speaking-of-science/wp/2... My wife studies Alzheimer's and I hope she will respond here, but I'm afraid she gets too angry by sensationalist stories based on editorials rather than mainline research. Of course there is inflammation involved. From what I understand talking with her, there is not much mechanistic work done with human tissue;…
You almost certainly have CMV, and that definitely contributes to the progression towards dementias via chronic inflammation and other immune dysregulation. There are many papers on CMV and immune aging if you care to go digging.
Alzheimer's is as inflammation-driven as, say, heart disease. Which is to say that inflammation is a meaningful contributing factor along with all the other meaningful contributing factors. This is primarily these conditions are linked with obesity, because visceral fat is a major source of inflammation.
E.g.:
http://www.southampton.ac.uk/news/2016/01/blocking-brain-inf...
http://www.manchester.ac.uk/discover/news/treatment-option-f...
Re: Virus and Two Types of Bacteria as Major Causes of Alzheimer’s
#10Earlier quoted context omitted.
Plus it's hard to take the researcher seriously when it looks like they created their own university. "Professor Resia Pretorius of the University of Pretoria"
> Pretoria: Capital of South Africa founding a city to start your own University sixty years later to publish a paper another hundred years later, that's what I call the long-con.
LOL