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Extreme side-effects of antidepressants

bbc.co.uk

41–50 of 99 posts

Re: Extreme side-effects of antidepressants

#41
post #6

Some thoughts from someone who's been prescribed anti depressants in adolescence but never took them because I believed the doctor misdiagnosed: * Do these drugs genuinely help or is it just a strong placebo response? * If the anecdotal evidence increases the odds from 1 in 100 to 1 in 4, would this be considered normal in medicine? Of course the symptoms could be attributed to the wrong thing here but they sound pre…

Heh, as someone who was on SSRIs for a long time at high dosages, they definitely do something, but the issue is less whether the drugs do anything and more what you do during that time.

Personal experience with Sertraline - it doesn't make you happy or feel better or anything. It just numbs you, and you're really susceptible during this time. It's part of the reason why therapy is also really important in addition to the drugs to help get down to the core of what you're having issues with.

The old Zoloft "sad blob" to "happy blob" commercials are a real disservice to modern anti-depressant medicine since it is a very incomplete picture. Aside from glossing over the side effects of the medication, the pills themselves don't do much except stop the feeling of absoutely horribleness for awhile. They don't make you feel better - they don't make you feel much of anything. But things at least stop seeming hopeless after awhile, and hopefully you can begin to address the underlying issues.

In the case of true chemical imbalances like it's suspected I have, during this time you help find non-drug related coping mechanisms. Finding ways to help create a strong positive part of your life so the imbalances are offset and don't hit as hard. A lot of this comes just through therapy or at least a counselor while you work.

My first few times on SSRIs were the result of rather serious and dangerous break downs where those around me had pretty good reason to think I was a threat to myself. But these cases were mishandled pretty heavily since the doc just wrote a prescription for Sertraline and sent me on my way. Therapy wasn't even discussed, and our insurance at the time certainly didn't cover it since it was a non-essential medical procedure.

It wasn't until many years later and many changes of drugs later that I was finally in a position when I could do both therapy and have the drugs to assist that I actually made some progress -- the counselor and the psychiatrist worked in tandem; the counselor worked and would constantly try to see how I was when we lowered the dosage, the psychiatrist spent time making sure that the dosage was enough to keep me level, not pushing either way and consulting with the counselor to ensure they had a source of info that wasn't me.

I hope we find something better since looking back at the SSRI period, it was not a very good time in my life and I was lucky enough to get to a situation where I could get proper mental healthcare. I can't imagine how many others were just tossed on an SSRI without the proper monitoring and assistance necessary to actually make use of the effect, or worse, who weren't watched at all as the more dangerous side effects kicked in.

Re: Extreme side-effects of antidepressants

#42
post #37

Earlier quoted context omitted.

My wife went through a rough patch a little while ago and decided she was depressed. She had no problem getting SSRIs prescribed by the doctor. She says as soon as she started taking them, she instantly felt better. No more randomly bursting into tears. But, she is no longer the wife I had. Her conversation is so slow. She regularly forgets what she was talking about, repeats herself. Basic chores are just forgotten…

Take her to a competent psychiatrist, maybe one that practices in a hospital. I've never come across a symptom/side-effect profile like that before. But at least some of them (I am not a psychiatrist etc. etc.) hint at bipolar disorder. One of the (unfortunately common) ways people learn that they have bipolar is by being mis-diagnosed with unipolar depression, being prescribed SSRIs, and suddenly finding themselves…

This is an excellent comment.

The "let's destroy every piece of furniture in the house" is exactly what happened with one of my parents, it's not a fun thing to witness but they eventually got the bipolar under control with lithium but the toxicity on that stuff is pretty horrible, regular blood tests for the rest of your life horrible.

Re: Extreme side-effects of antidepressants

#43
post #30

Earlier quoted context omitted.

> I didn't say that, I said that "increasing serotonin" is not why these drugs sometimes help people feel better. Yes it is. Only some people don't have too little serotonine.

Then, can the lack of serotonin really be the main, or only cause of depression ? If people with sufficient serotonin levels can get depression, then how can we argue that the actual increased seratonin levels is what helps people recover from it ? It seems like a quite strange argument to me.

Because depression, like most psychological diagnoses, is defined as a pile of symptoms, not as a specific illness like the flu. We don't know all the different things that can cause depression.

One of the things that we're reasonably sure can cause depression is decreased levels of serotonin. That doesn't mean there's not other things which cause more-or-less the same set of symptoms.

EDIT: On a note related to your girlfriend... people can appear externally happy while being seriously depressed. From talking to me irl, you'd likely never guess that I self-harm, have no motivation to do anything, and wish I were dead. You can't blame someone for wanting an escape from that.

Re: Extreme side-effects of antidepressants

#44
post #38

This is a subject I know well, not only as a multi-decade prescriber of antidepressants, and many other classes of medications for health/behavioral problems. I've also been prescribed such medications for my own conditions, so you could say I have a unique perspective, know the issues coming and going. Of course antidepressants can cause side-effects as do all other types of drug treatments. It's inevitable, medicat…

> 1% of recipients is considered a common adverse effect

Are these rates determined in the same conditions as the medications are prescribed?

Are there methods put in place to continue to gather side effect data after a medication is prescribed?

Re: Extreme side-effects of antidepressants

#45
post #28

I've been prescribed multiple SSRIs over the last decade. 5, by my count. I've also researched them pretty extensively for about the same time. They are a crap-shoot at best. The best that a knowledgeable and well intentioned doctor can do is prescribe them in a trial and error fashion, maybe with a tiny bit of guidance from prominence of patient symptoms. But it's largely just prescribe, wait 6 weeks, rinse and repe…

My wife went through a rough patch a little while ago and decided she was depressed. She had no problem getting SSRIs prescribed by the doctor. She says as soon as she started taking them, she instantly felt better. No more randomly bursting into tears. But, she is no longer the wife I had. Her conversation is so slow. She regularly forgets what she was talking about, repeats herself. Basic chores are just forgotten…

Please intervene. Get her some real counseling! Get her to a psychiatrist! And when she is able, get her exercising and taking probiotics. Good luck.

Re: Extreme side-effects of antidepressants

#46
I have friends who struggle with depression and are not allowed antidepressants, exactly because they are suicidal. My wife claims she could easily get antidepressants if she wants them, because she's neither suicidal nor depressed. Makes you wonder what the point of antidepressants is, if they're dangerous only to the people who actually need them.

Re: Extreme side-effects of antidepressants

#47
post #46

I have friends who struggle with depression and are not allowed antidepressants, exactly because they are suicidal. My wife claims she could easily get antidepressants if she wants them, because she's neither suicidal nor depressed. Makes you wonder what the point of antidepressants is, if they're dangerous only to the people who actually need them.

I'm by no means an expert in this area, but looking at your reasoning, perhaps antidepressants are suitable for people who are depressed but not suicidal.

Every medicine has side effects. Every medicine has contraindications and is not suitable to a subset of the population which may want to use it. It looks like antidepressants are no different.

Re: Extreme side-effects of antidepressants

#48

Earlier quoted context omitted.

My wife went through a rough patch a little while ago and decided she was depressed. She had no problem getting SSRIs prescribed by the doctor. She says as soon as she started taking them, she instantly felt better. No more randomly bursting into tears. But, she is no longer the wife I had. Her conversation is so slow. She regularly forgets what she was talking about, repeats herself. Basic chores are just forgotten…

Please intervene. Get her some real counseling! Get her to a psychiatrist! And when she is able, get her exercising and taking probiotics. Good luck.

You talk as though I have any control over her whatsoever. She is pretty much uncontrollable. If I tried to suggest she needs to see a psychiatrist it would pretty much ensure she would never see one.. I am pretty much at the end of my tether now.

Re: Extreme side-effects of antidepressants

#49
post #37

Earlier quoted context omitted.

My wife went through a rough patch a little while ago and decided she was depressed. She had no problem getting SSRIs prescribed by the doctor. She says as soon as she started taking them, she instantly felt better. No more randomly bursting into tears. But, she is no longer the wife I had. Her conversation is so slow. She regularly forgets what she was talking about, repeats herself. Basic chores are just forgotten…

Take her to a competent psychiatrist, maybe one that practices in a hospital. I've never come across a symptom/side-effect profile like that before. But at least some of them (I am not a psychiatrist etc. etc.) hint at bipolar disorder. One of the (unfortunately common) ways people learn that they have bipolar is by being mis-diagnosed with unipolar depression, being prescribed SSRIs, and suddenly finding themselves…

Interesting. I haven't looked into bipolar before.

Re: Extreme side-effects of antidepressants

#50

Earlier quoted context omitted.

My wife went through a rough patch a little while ago and decided she was depressed. She had no problem getting SSRIs prescribed by the doctor. She says as soon as she started taking them, she instantly felt better. No more randomly bursting into tears. But, she is no longer the wife I had. Her conversation is so slow. She regularly forgets what she was talking about, repeats herself. Basic chores are just forgotten…

Please intervene. Get her some real counseling! Get her to a psychiatrist! And when she is able, get her exercising and taking probiotics. Good luck.

It also doesn't help that I have aspergers. So she assumes all her problems are down to that and its me who just needs to sort things out..
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