Did a quick comparison test with this beautiful piece of artwork I just created. original http://i.pi.gy/0K7d.png (2.1 MB) jpeg.io http://i.pi.gy/AP8v.jpg (102 KB) Photoshop 60% jpeg Export http://i.pi.gy/Wr4P.jpg (90 KB) tinypng.com http://i.pi.gy/ndKA.png (74 KB) Note pi.gy does not compress uploads.
Since he doesn't summarize the test above, let me. The jpeg.io result is bigger than the other two and noticeably worse quality. The problems were with the sharp lines. Perhaps jpeg.io specializes in photo-realistic pictures rather than graphics and logos.
One of the worst case scenarios for chroma subsampling is alternating black and red lines. Some monitors/TVs do 4:2:0 by default. It can cause problems...
https://plus.google.com/photos/photo/100697962438000631056/5...