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Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

scientificamerican.com

31–40 of 98 posts

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#31

Earlier quoted context omitted.

You have to choose a system. If we don't want naturally-occurring compounds patented, but we want them researched for potential drug use, we need more public funding. Otherwise, we have to offer researchers and drug manufacturers an incentive to take risks with exploring these compounds. Barring lugdunin from being patented while providing no public funding would incentivise this group to withhold publication until t…

At least if they'd kept their findings secret, researchers could independently be researching the same thing. Now independent researchers won't want to touch lugdunin because they'll need to license the patent, however they won't know whether licensing the patent is worthwhile until they do their research. This will prevent further research, not encourage it.

Worse, other commercial researches will be wasting their time with busywork to find a non-patented analog which they can claim for themselves, instead of working on new things.

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#32
post #30

An interesting point would be that if S. aureus becomes resistant to lugdunin (a matter of a few years maybe), S. lugdunensis might evolve naturally to find a new antibiotic. So a similar study in a few years might lead to a new antibiotic molecule targetting the mutated S. aureus. Is there hope for this or is it nonsense?

I was just thinking something similar - maybe the future for bacterium-specific treatments isn't to try and find a new antibiotic, but rather to pit different nasty bacteria against each other in an endless in-vitro cage match, then analyze the winner to learn their tricks?

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#33

Awesome research. But... > The researchers then checked snot from hospitalized patients. Of 187 samples, all but one were colonized by either S. aureus or S. lugdunensis > S. lugdunensis, was killing S. aureus. Its weapon of choice? A small compound dubbed lugdunin > The German researchers who performed the study have filed a patent for lugdunin Are we really allowing people to patent naturally occurring biological c…

You have to choose a system. If we don't want naturally-occurring compounds patented, but we want them researched for potential drug use, we need more public funding. Otherwise, we have to offer researchers and drug manufacturers an incentive to take risks with exploring these compounds. Barring lugdunin from being patented while providing no public funding would incentivise this group to withhold publication until t…

These are German researchers at a German university. Aren't they already publicly funded? (honest question, I don't know).

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#35

Earlier quoted context omitted.

You have to choose a system. If we don't want naturally-occurring compounds patented, but we want them researched for potential drug use, we need more public funding. Otherwise, we have to offer researchers and drug manufacturers an incentive to take risks with exploring these compounds. Barring lugdunin from being patented while providing no public funding would incentivise this group to withhold publication until t…

These are German researchers at a German university. Aren't they already publicly funded? (honest question, I don't know).

I don't know but it wouldn't make a difference as long as someone else could come along and take out a patent on what they found.

This is the sort of thing that requires and international treaty.

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#37

Now we need a globally agreed system of anti-biotic triage - you can have anti-biotics, but only administered in hospital, signed off by two doctors and with these life threatening conditions. Treat them with care this time round

> signed off by two doctors

And then we get to complain about the excess bureaucracy in healthcare!

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#38

Now we need a globally agreed system of anti-biotic triage - you can have anti-biotics, but only administered in hospital, signed off by two doctors and with these life threatening conditions. Treat them with care this time round

That would overwhelm our hospital system.

It's possible to find middle ground, and I think comprehensive IT systems for all doctors with real-time forbidden drugs lists and epidemia tracking would make this much easier.

It's even possible to divide hospitals into "different drug is forbidden here", and when someone has MRSA - put him in a hospital where the drugs that doesn't work on him - are banned anyway. And use "last ditch" drugs only in these hospitals.

And of course the main thing is to stop abusing antibiotics for agriculture.

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#39

Partly relevant: a few months ago they discovered bacteria in beards that also kill MRSA: http://www.independent.co.uk/news/science/beards-good-for-he...

Interesting read. What I don't understand is why other body hair is not mentioned, and if that has the same effect. If not, what makes a beard different?

Re: Nasal Bacteria Pump Out a Potential New Antibiotic That Kills MRSA

#40

Awesome research. But... > The researchers then checked snot from hospitalized patients. Of 187 samples, all but one were colonized by either S. aureus or S. lugdunensis > S. lugdunensis, was killing S. aureus. Its weapon of choice? A small compound dubbed lugdunin > The German researchers who performed the study have filed a patent for lugdunin Are we really allowing people to patent naturally occurring biological c…

Could they be patenting it to prevent others from doing so?

They'll probably make some money out of it, to fund more research, but hopefully any deal with pharmaceutical companies should have some pricing clause to make this widely affordable to public health services.

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