Live data from Hacker News

Exercise Releases Brain-Healthy Protein

directorsblog.nih.gov

111–120 of 186 posts

Re: Exercise Releases Brain-Healthy Protein

#111
post #107

There is a strange dichotomy here... I do believe that exercise helps thinking, but when I was growing up, very few of the smarter people were involved in sports, either formally or informally. Perhaps 1 in 20 was on a team, and few were that active otherwise. The link to drama and music was much bigger.

Percentage of high school seniors who participated in various school-related extracurricular activities, by sex: 1990 and 2001 - https://nces.ed.gov/programs/youthindicators/Indicators.asp?... If artistic ability has a strong influence on intelligence compared to athleticism, then P(intelligent | artistic) >= P(intelligent | athletic). We know that P(athletic) > P(artistic) from the data. By Bayes' theorem: P(intelli…

But did you run the numbers? I can't go through the link.

Re: Exercise Releases Brain-Healthy Protein

#112
post #107

There is a strange dichotomy here... I do believe that exercise helps thinking, but when I was growing up, very few of the smarter people were involved in sports, either formally or informally. Perhaps 1 in 20 was on a team, and few were that active otherwise. The link to drama and music was much bigger.

Percentage of high school seniors who participated in various school-related extracurricular activities, by sex: 1990 and 2001 - https://nces.ed.gov/programs/youthindicators/Indicators.asp?... If artistic ability has a strong influence on intelligence compared to athleticism, then P(intelligent | artistic) >= P(intelligent | athletic). We know that P(athletic) > P(artistic) from the data. By Bayes' theorem: P(intelli…

There is nothing in the data that says that participation is exclusive, "other" bucket is larger than "performing arts". So the whole thing is invalid. But most importantly participation doesn't mean ability. There are plenty of people in both camps who clearly are not able.

Re: Exercise Releases Brain-Healthy Protein

#113
post #102
post #88

Earlier quoted context omitted.

This correlates with my personal experience. Lifting is a good idea, but my optimum for it is perhaps once a week, else I fall into overtraining. The rest of the time when I want to exercise mild cardio seems more beneficial.

Maybe that works for you, but you'll never be strong/look strong weight training weekly. If you're "overtraining" from one weight training session per week, there's something very wrong. The average human only takes 48-72 hours to fully recover for most muscle groups in the body. It's also been proven that HIIT is much more beneficial for your system than LISS. It might "seem" more beneficial to you, but likely is no…

>It's also been proven that HIIT is much more beneficial for your system than LISS.

Source? What is your definition of 'better?' The context is in longevity, and my link offers some evidence against your statement, so I think you should provide some source for your claim that HIIT is consistent with living longer than LISS because that's not what I've seen published in the last 10 years.

Re: Exercise Releases Brain-Healthy Protein

#114

Earlier quoted context omitted.

Interestingly, exercise itself actually helps get an energetically favorable type of energy to the brain in the first place: lactate.[1] Moreover, lactate in the brain triggers the release of BDNF, which causes neurogenesis.[2] I recorded a video conversation with the pioneer of the lactate shuttle theory behind this mechanism which may interest you. https://www.youtube.com/watch?v=lThFQM503EU [1] https://en.wikipedi…

Exercise also causes the release of endorphins in the brain that leads to a condition commonly known as "runners high". http://www.runnersworld.com/running-tips/how-to-achieve-a-ru...

Actually there is some evidence to suggest that the runners high is due to endocannabinoids rather than endorphin release. Interestingly the endocannabinoid system is also activated when consuming cannabis and experiencing the resulting cannabis/runners high.

http://cen.acs.org/articles/93/web/2015/10/Exploring-Molecul...

Re: Exercise Releases Brain-Healthy Protein

#115
post #101

Earlier quoted context omitted.

This does not imply that, for example, a daily or weekly peak of energy expenditure was the same. As training once per week for 15 minutes with weights is enough to grow muscles, it could be that hunter/gatheres needed to release energy at the max level like running away from a lion much more often than we do nowdays and during those releases the brain also had to work hardest.

>during those releases the brain also had to work hardest That is speculation, and is unintuitive. Why would the brain "work hardest" when running? Why would modern humans not exert the same forces during sport? Why would humans, the top group-oriented predator, run from a lion? The data linked above shows that observed Physical Activity Levels and caloric use are comparable to modern day. Stop inserting your own ass…

> Why would humans, the top group-oriented predator, run from a lion?

I'd sure run from a lion if it was coming at me.

Re: Exercise Releases Brain-Healthy Protein

#117
post #66

Earlier quoted context omitted.

Exercise also causes the release of endorphins in the brain that leads to a condition commonly known as "runners high". http://www.runnersworld.com/running-tips/how-to-achieve-a-ru...

Real runner's high means you started damaging your muscles and brain flushes endorphins to your blood stream in order to keep you being able to continue without experiencing debilitating pain in case you are running from a disaster/predator/death in the last attempt before you cease to be able to move. Not something you'd want to achieve repeatedly.

Then I'm not sure I ever got Runner's High. I did get Runner's Crave after one week tied to a bed. I couldn't stay in place and was anxious all the time, fantasizing about climbing the stairs between the hospital floors.

Re: Exercise Releases Brain-Healthy Protein

#118
post #66

Earlier quoted context omitted.

Real runner's high means you started damaging your muscles and brain flushes endorphins to your blood stream in order to keep you being able to continue without experiencing debilitating pain in case you are running from a disaster/predator/death in the last attempt before you cease to be able to move. Not something you'd want to achieve repeatedly.

>Not something you'd want to achieve repeatedly. My memory is telling me that studies of exercise show the longest living are those that do anything from endurance to what the article below calls "mixed" sports. Powerlifting and high intensity training may offer some benefit, but it is not as much as endurance training. What I found in a quick Google search to attempt to refresh my memory, is in agreement: http://wel…

Endurance exercise displays an inverted U curve in terms of longevity.

Strength is highly correlated with reduced all cause mortality. Which direction the relationship goes is debatable, but being strong is pretty sweet in and of itself.

Re: Exercise Releases Brain-Healthy Protein

#119

For all the entrepreneurs wanting to bottle Cathepsin B (the "Brain-Healthy Protein"), unfortunately it has also been linked with tumour invasion and metastasis[1]. Further study is needed to know if the increase in Cathepsin B is a factor or simply correlation. [1] http://www.ncbi.nlm.nih.gov/pubmed/14587299

That's assuming the unscrupulous spam artists pushing nootropics and smart-pills even care about the adverse effects of the ingredients they're selling. And most of their target consumers will be too wooed by the use of a scientific term like 'cathepsin-b' to bother with their own due diligence.

Re: Exercise Releases Brain-Healthy Protein

#120

Earlier quoted context omitted.

>Not something you'd want to achieve repeatedly. My memory is telling me that studies of exercise show the longest living are those that do anything from endurance to what the article below calls "mixed" sports. Powerlifting and high intensity training may offer some benefit, but it is not as much as endurance training. What I found in a quick Google search to attempt to refresh my memory, is in agreement: http://wel…

Endurance exercise displays an inverted U curve in terms of longevity. Strength is highly correlated with reduced all cause mortality. Which direction the relationship goes is debatable, but being strong is pretty sweet in and of itself.

Source?

Anyways I've run marathons in the past, but I mostly do strength training now, actually mostly callisthenics. It's less dedication, gives me more of an adrenaline rush and easier to do than endurance training. I don't deny, though, that most of what I've read says that cardio is better if you just simply want to live as long as possible.

Post reply on HN