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OxyContin's 12-hour problem

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Re: OxyContin's 12-hour problem

#241
post #127

Earlier quoted context omitted.

It's often used inappropriately, which is one reason to use less of it and use other better alternative. It's a significant cause of death in suicide so that's another reason to use less of it. It accounts for a lot of accidental death, so that's yet another reason to use less of it.

Right, that's the moralistic part. However, physiologically it remains an actual treatment path. How are opiates a significant cause of suicide? How do they compare to the antidepressants I see advertised on TV that mention an increased likelihood of suicidal thoughts? There are actual people with actual suffering involved here, remember that. Don't let your misconceptions of junkies determine public heath policy.

I forgot the cites! Sorry.

The first is the National Confidential Inquiry into Suicide and Homicide by People with Mental Illness http://www.bbmh.manchester.ac.uk/cmhs/research/centreforsuic...

The second are the Office for National Statistics mortality data. Here's deaths: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdea...

And here's suicide: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdea...

(Watch out. They count slightly different things. But they should both be clear enough about what they're counting).

Here's a map showing medications that are prescribed across England. You can noodle around with the data to see what's prescribed or not, and how much, and by what doctors offices: https://openprescribing.net/

Re: OxyContin's 12-hour problem

#242

I can't believe how doctors apparently routinely prescribe addictive painkillers in the US. Here in Europe, as far as I know, doctors only prescribe non-opioid painkillers. I don't know anyone who was prescribed an opioid drug outside of an ICU. Ibuprofen is surprisingly effective for many types of pain, I don't see why doctors immediately prescribe something as dangerous as OxyContin.

You can buy opioids over the counter in France. Codoliprane for example has 500mg of paracetamol combined with 30mg of codeine. Codeine is not the hardest opioid, but still...

Sadly many people die from accidental paracetamol overdose.

Re: OxyContin's 12-hour problem

#243

> it appears they offered a cushy job to a > government official in exchange for favorable > regulatory treatment I suspect that that sentence is legally actionable as slander, as well as being an (apparently) completely baseless claim of illegal activity.

We detached this subthread from https://news.ycombinator.com/item?id=11649541 and marked it off-topic.

Re: OxyContin's 12-hour problem

#244

Just to be clear, Maher has an extreme distrust of modern medicine, to the point that it led me to almost totally abandon his show. For example, he gave the fraud Sam Chachoua an inordinate amount of airtime for someone claiming he can cure HIV with goat's milk. As far as I know Maher is still an antivaxxer, as well. http://rationalwiki.org/wiki/Bill_Maher#Medicine Anyways, I've realized to take Maher's views and end…

We detached this subthread from https://news.ycombinator.com/item?id=11649577 and marked it off-topic.

Re: OxyContin's 12-hour problem

#245

It's quite simple: Don't do drugs. Next question please.

Yeah, I'll stop taking the drugs that allow me to function and have any kind of quality of life. That's a great suggestion! however if I do it's quite simple, don't do drugs, can you do it's quite simple don't be an empathy lacking idiot?.

No personal attacks on HN, please, regardless of how wrong or provocative someone else's comment is.

Re: OxyContin's 12-hour problem

#246

Earlier quoted context omitted.

> But I don't understand how people can be so pro marijuana on one hand, and so anti-opiates on the other. It's pain. It's not noble to suffer needlessly. Weed is not addictive, or even if it is in some people, to nowhere near the same level as opiates. It's also not responsible for thousands of overdose cases per year. It seems to me that THC pills would be better for pain management in these situations than opiate…

Weed is not physically addictive like opiates are, but people do become psychologically dependent upon it to avoid dealing with stress and anxiety in healthier ways. And it can become difficult to stop if you haven't resolved the underlying problems that you're treating with it.

Oh yes, just like chocolate then.

Re: OxyContin's 12-hour problem

#247

Earlier quoted context omitted.

Sure, it's an opioid. That's not the point. The point is that it's made from an inexpensive generic opioid feedstock: oxycodone. The supposed value-add isn't the painkiller, it's the timed-release agent. Unless these reporters are simply lying, there's evidence of great variability in the effectiveness of that timed-release agent. But the company's market position depends on the 12-hour dose. If the drug's needed eve…

Isn't NA mandated by courts? Even for pot sometimes? A growing group could easily just mean a change in law enforcement or sentencing.

Which is a terrible intrusion upon people voluntarily there for actual support and help.

Re: OxyContin's 12-hour problem

#248
post #164

Earlier quoted context omitted.

Hm, I can't edit my comment anymore, but French wiktionary claims that French "livre" (meaning pound) comes from the Latin word for the measure that weighed about as much as a book. ("livre" also means "book" in French). I guess "lb." and French "livre" (meaning pound) aren't necessarily related. More likely: wiktionary could be full of shit, meaning I was wrong.

You have misunderstood the wiktionary entry: > Du latin lībra (« poids d’une livre ») tells you just that the meaning of the latin word is a measure of weight (a pound). There is no way that can be interpreted as "the weight of a book" (that would be « poids d’un livre »).

Oh shit! I read it as "un".

Re: OxyContin's 12-hour problem

#249
post #123

Earlier quoted context omitted.

Urban myth? This probably varies from place to place, but certainly all the physicians I'm close to are treated to very good food every day, and will accept occasional invitations to attend fun events with sales reps. Drug companies do their best to create an informal quid pro quo atmosphere. Many drug companies are involved, so they are clearly seeing returns from their physician influence. More overtly, drug compan…

First, and I want to make clear that I am strongly against any drug rep presence in any medical institution, and have advocated against it in institutions I've been affiliated with: let us draw a hard line between three levels of behavior, because conflating them is ... well, not ridiculous, not quite, but misleading. It's not ridiculous to group "slapping someone" with "beating them with a baseball bat," but it lose…

> physicians that get this money are now publicly monitored for it.

> Again, these have grown increasingly rare since these are now public numbers subject to scrutiny.

Where can I access this information?

Re: OxyContin's 12-hour problem

#250
post #205

Earlier quoted context omitted.

> It would make the economic cost of addiction lower for the individual Isn't a low cost of addiction a bad thing? I'm also not just talking about legalization, but mainly the thing about deregulation/competition. I see your logic though, I hope it's not too wishful to assume that less doctors pushing drugs on patients will solve the issue. I suppose it definitely will cut it back some.

No, it's a good thing. It means people that are addicted (by choice or not) don't need to resort to crime or desperation to buy essential medicines. Less doctors "pushing" really means more doctors being very critical of patients. Which means more people in pain, scared to make too big a fuss, lest they be labeled an "addict" or "seeker". We don't accept (in theory) a legal system that condemns innocent people to suf…

> No, it's a good thing. It means people that are addicted (by choice or not) don't need to resort to crime or desperation to buy essential medicines.

This seems twisted to me. Okay, so they don't do crime, but they get their stuff easier and stay addicted/get worse/die. Isn't it best to eliminate the motivation for doctors to overprescribe, but still force people to see their doctors for a fix? This way maybe the doctors can intervene and help them out.

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