I currently live in an area where I find it somewhat difficult to make new friends, and I'm not entirely sure why that's the case. Generally speaking, the people where I live are more interested in football/beer than technology/startups, but I actually don't think that is the reason for my difficulty — I am good friends with some football fanatics, and there are some technically-minded people who I can't stand. (And I certainly don't mean to imply that there's anything wrong with football and beer — I merely point out that these are not interests of mine!)
Honestly, I can't quite figure out what causes me to mesh well with some people and not others. I get along great with my girlfriend and my sister, and I can talk to them for hours even though neither is interested in science or technology.
And I don't think it's morals/values either — I'm friends with people whose political views are completely opposed to my own.
If someone can figure out what actually causes people to "click" with one another, then I think a startup for making friends might actually be successful.