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What Your Microbiome Wants for Dinner

nautil.us

51–60 of 99 posts

Re: What Your Microbiome Wants for Dinner

#51
post #6

That's an interesting article, for sure. It also applies to what I've been diagnosed with as well. Type 2 diabetes. I'm applying data science to this disease. It's what I do, and can afford. Unfortunately, my doctor thinks that pushing pills is an adequate response, which I heartily doubt. The more I understand this disease, it has to do with either: pancreas is dead (type 1), or your glucose response/insulin respons…

I've been a Type 2 diabetic officially for 18 years but impaired glucose tolerance for longer. You're on the right path, there's a lot you can do to slow down the progress of the disease.

I'm not a doctor however so take any advice with a grain of salt. (But not sugar, definitely not that.)

> I keep reading that the problem is carbohydrate overload to my genetics.

Read up on "glycemic index". This index tells you how close your food is to pure glucose e.g. table sugar has a glycemic index of 68 so it has 68% of the insulin response of pure glucose. The index correlates to the type of carbohydrate and how processed it is, although there are some surprises e.g. premium ice cream has a G.I. of 37.

http://www.glycemicindex.com/index.php

You don't have to commit the entire index to memory. Usually you can come up with several heuristics e.g. tropical fruit tends to have higher G.I. than temperate fruit.

Obviously you should test this with your own blood sugar readings as individual response to a carbohydrate challenge can be quite different.

The other components to a meal also affect blood sugar. For example, acid, protein and fat tend to slow down digestion and thus blood sugar spiking. If you must take pasta for example, take it with a tomato-based sauce (acidic) rather than cream-based. YMMV.

> Unfortunately, my doctor thinks that pushing pills is an adequate response, which I heartily doubt.

It's important, although somewhat depressing, to see this disease as a progression. A progression that you have to slow down as much as possible, but still a progression.

Know that in the future, you may have to resort to the first line of pills, and then possibly stronger ones. Try to slow down the progression as much as possible, and research the pills to see their efficacy and benefit.

Metformin is usually the first line of defence and it has a long history and little side effect. It generally fools your body into thinking it's in starvation mode, which means you can lose weight, both fat and muscle. It actually lowers insulin resistance rather than increasing insulin. Generally in amounts >1g it gives you loose bowels, so when you have to use it keep on low doses as long as possible.

When metformin doesn't work as well, generally you'll get prescribed sulfonylureas. Since they increase insulin secretion, they tend to exacerbate your insulin resistance. There is some inconclusive research that they burn out the pancreatic beta cells. Better to avoid these as long as possible, but if your glucose control is bad you may not have a choice.

I'm currently on an incretin enhancer (gliptin) + metformin.

Also look up supplements on examine.com. It's hard to tell the effectiveness of supplements, the only one that had a distinct effect on me was berberine.

The other thing you can do is exercise. Lots of it. Strength training for more muscle and more insulin receptors. Aerobic exercise to burn/absorb more glucose and lose weight. There's even recent evidence that high-intensity interval training improves diabetic markers more than sustained, low-intensity exercise.

Re: What Your Microbiome Wants for Dinner

#52
post #26
post #15

Earlier quoted context omitted.

Are you able to watch this BBC TV program? (I hope it's the right one: my wife suggested it.) http://www.bbc.co.uk/iplayer/episode/b06rdtx0/doctor-in-the-...

I'm not able to watch it. Is it this per chance? https://www.youtube.com/watch?v=fFfkdKfpgFw

No, completely different ;-)

Episode that impressed my wife basically showed a women stop having diabetes 2 a few weeks after being put on a no-carb (well, no sugar and no high-glycemic carbs, but meat, fruit and veg) diet.

Re: What Your Microbiome Wants for Dinner

#53
post #11

It's a book extract: "Excerpted from The Hidden Half of Nature: The Microbial Roots of Life and Health by David R. Montgomery and Anne Biklé. Copyright © 2016 by David R. Montgomery and Anne Biklé. With permission of the publisher, W.W. Norton & Company, Inc. All rights reserved." Based on that section, I would look for an extract from The Good Gut (1) instead. It leans more towards science and less towards populariz…

I just read Good Gut, it's a very very very bad book. About 10% enlightening accepted science and about 90% rampant and very wild speculation. Filled with little chapters that take in many cases very tenuous unproven theories (they come out and say that) and then use weasel words to then write a whole speculative chapter about it. I learned a lot about how digestion works and then a lot about how to make a book out o…

Views obviously differ. Both the authors (1) have very senior positions at the Sonnenburg Lab in the Department of Microbiology and Immunology at Stanford University, so I'd be quite surprised if the book is as bad as you claim.

Also, Amazon reviewers have given it 4.7 stars out of 5, which suggests quite a few people found it useful.

(1) Justin L. Sonnenburg. Principal Investigator, and Erica D. Sonnenburg. Senior Research Scientist.

Re: What Your Microbiome Wants for Dinner

#54
post #8

One topic that was not mentioned in the article that I have found fascinating is that your gut microbiome can actually affect your cravings. (1) Your microbiome accomplishes this through a host of mechanisms including changing the expression of taste receptors, making certain foods taste better; they may release hunger-inducing hormones; or they may manipulate the vagus nerve (which connects the stomach to the brain)…

> One topic that was not mentioned in the article that I have found fascinating is that your gut microbiome can actually affect your cravings It's worth noting that the study[1] does not suggest that. It says that there has been some "circumstantial evidence for a connection between cravings and the composition of gut microbiota" and notes that there would be evolutionary pressure on microbes to be able to influence…

I'm not sure about chocolate cravings. The scientist I heard talk had done some experiments on her self that eating chocolate for a while produced cravings but I guess that could be psychology rather than bacteria. There have been solid studies on gut bacteria making people fat and thin, presumably by effecting their desire to eat. See eg http://www.nytimes.com/2013/09/06/health/gut-bacteria-from-t...

The experiments basically fed gut bacteria from thin creatures, (mice / humans) to fat ones (mice) and they lost weight and visa versa for fat to thin. I guess you could extend that experiment quite easily to mice and chocolate though I'm not sure it's been done yet. Maybe if anyones got some experimental mice and bars of chocolate knocking around they could report back?

Re: What Your Microbiome Wants for Dinner

#55
post #34

Earlier quoted context omitted.

Speed of evolution depends on how strongly the adaptation influences reproductive success. It's possible that grain causes subtle long-term damage that mostly kills people past reproductive age, whereas lactose tolerance is of immediate benefit. If this is true then grain tolerance would evolve much slower than lactose tolerance. But note that the "subtle long term" damage argument applies to all foods, and it's unce…

> It's possible that grain causes subtle long-term damage that mostly kills people past reproductive age, whereas lactose tolerance is of immediate benefit. Sure, and it's also possible the human body has already adapted to processing grains without long term damage, and it's possible that there was never any damage by consuming grains in the first place (the body is highly adaptable). All this line of argument is st…

And, as many gluten-sensitive (but not allergic) people told in a recent thread on reddit, where the topic came up, they have next to no issue with the hand-baked bread you find in small bakeries in Europe, but the issues often only show when eating mass-produced bread.

It’s more likely that gluten sensitivity is just caused by a cross-interaction with an additive used for bleaching or similar.

Re: What Your Microbiome Wants for Dinner

#56
post #19

Earlier quoted context omitted.

You don’t even need to omit the grains. You can just eat Dinkel or Urkorn, two very common (like, in every bakery) types of grain that existed even in the paleolithic times. EDIT: Seriously, how is this not contributing? Please provide a comment if you think it is not contributing.

No matter the seed you will find in the vast majority of cases they contain anti-nutrients that are toxic to mammals. Lectins, glutens, phytates, etc.

Since when is gluten "toxic", not just "leads to an allergic reaction in a minority of the population"?

Re: What Your Microbiome Wants for Dinner

#57
post #19

Earlier quoted context omitted.

You don’t even need to omit the grains. You can just eat Dinkel or Urkorn, two very common (like, in every bakery) types of grain that existed even in the paleolithic times. EDIT: Seriously, how is this not contributing? Please provide a comment if you think it is not contributing.

No matter the seed you will find in the vast majority of cases they contain anti-nutrients that are toxic to mammals. Lectins, glutens, phytates, etc.

But fermentation (like in sourdough) can fix this right?

Re: What Your Microbiome Wants for Dinner

#59
post #28
post #7

This article opens with, "[New science] is also showing us that advocates of trendy paleo and vegan diets are missing the big picture of how our omnivorous digestive system works." But it concludes with, "Pick a modest-sized plate and make meals using vegetables, legumes, leafy greens, beans, fruits, and unmilled whole grains as the main ingredients. Add some meat if you want and dollops of healthy fats on the side o…

Dairy.

My thought as well. Milk, cheese, and eggs are unfashionable at the moment, for whatever reason; but that doesn't make them less valuable or desirable.

Is animal welfare the reason for dairy goods being out of fashion? I doubt it; it's easy to come by humane milk and eggs, although humane cheese, butter, kefir, yogurt, etc. are less common. And yet, vegans are the new vegetarians -- even the Jains are going vegan -- while we also get the paleo diet with its own reasons for being anti-dairy...

There's also hostility to bread. Bread and milk are historic European staples; a part of me suspects that hostility to these (at least in white Americans) is really about hostility to the past.

Re: What Your Microbiome Wants for Dinner

#60

What I would like to know is what happens to the colon when you go on a 20-day regimen of broad-spectrum antibiotics such as ciprofloxacin?

Nothing good, I'd imagine; intestinal flora tend to be antibiotics' first casualties. It's always a good idea to consume probiotic foods once you're off the medicine (or take intestinal-flora pills).
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