Viewing profile — flobosg

All those publications describe the methodology and modelling process to generate genomes, without testing them experimentally. This article shows that their designed genomes actua…

> Based on my quick reading, the BBC article doesn't bring up a prior publication / release from 2025 called "AI-Designed Phages," https://www.asimov.press/p/ai-phages That link is…

The publication: https://www.science.org/doi/10.1126/science.aec2657 It is paywalled, but this seems to be the corresponding preprint: https://www.biorxiv.org/content/10.1101/2025.…

> The from-the-hip cameras typically have a waist-level viewfinder That is the case with twin-lens reflex cameras, for example, which are not commonly used for street photography. …

It goes both ways, of course. There are Germans who do not take learning English seriously, and foreigners who stumble because many informal expressions (including jokes) are diffi…

Thanks for this comment. I also arrived in Germany into a similar bubble, but shortly thereafter it burst. I was forced to relocate to a backwater shithole (trust me, I’m doing my …

Brings to mind Jeff Bridges’ homepage: https://www.jeffbridges.com/

For a bit of context, Party Cannon is a death metal band with this logo: https://en.wikipedia.org/wiki/Party_Cannon#/media/File:Party...

According to the article metadata: "datePublished":"2026-07-16T08:18:37+09:00"

The Nintendo 64 Disk Drive (64DD) had the Randnet Browser.

> Mac Micro Mac Nano, just like iPods!

> Yes, as supplementary information Still part of the article.

Usually, journals require raw, unmodified data to be deposited as supplementary information.

> I would be more worried if the blotted area was different (the dark blob) Or if more than one blob is present (i.e. blobs at different molecular weights) for a supposedly selecti…

From the article: > This image is supposed to demonstrate that the antibody being sold works as intended. (…) Antibodies are near-ubiquitous but notoriously fickle laboratory reage…

Same with the TIM barrel fold. It can catalyze a wide range of reactions.

> since the data used to train AlphaFold is limited to existing experimentally determined protein structures Protein sequences, but the point still stands.

8G ought to be enough for anybody.

A small nitpick: chlorophyll is the pigment, photosystems are the protein complexes containing it. > So it works. But there has got to be a simpler/better/non-toxic way to create a…

> that structure is as/more important than sequence? Structure is determined by sequence, so they are equally important. Structure is more conserved than sequence, mainly due to th…

My PhD thesis addressed a similar question. I did a survey of sub-domain sized fragments shared between different protein folds. It turns out that there are plenty, even among fold…

This reminds me of structural studies in proteins encoded by de novo genes in eukaryotes. They are usually either intrinsically disordered or adopt a molten-globule-like state.

> Natural selection has no analogy with any aspect of human behavior, However, if one wanted to play with a comparision, one would have to say natural selection does not work as an…

Not sure if I understand your reply. Currently, the Sequoia beta channel is only getting security patches.

> switch to the Sequoia public beta channel! https://news.ycombinator.com/item?id=47198977#47202707