Once acquired, athlete's foot can become a chronic condition, especially for nurses. The foot fungus grows in the warm, moist environment of feet encased in nursing shoes. All nurses will attest that the extreme amount of time spent walking during a nursing shift leads to "warm feet". This heat builds up in nursing shoes and has little outlet for venting. Nurses who wear pantyhose instead of socks experience more heat buildup and moisture in shoes as the synthetic hosiery material does not wick moisture that is generated during prolonged walking away from the foot.

The replacement of the traditional nursing uniform dress with the more comfortable uniform scrubs has led to a decrease in nurses who wear pantyhose. Socks have now become a staple nursing uniform accessory. However, socks made of synthetic materials pose the same problem as the previously used pantyhose. To ensure maximum wicking of foot moisture, socks should be constructed of 100% cotton or of specially engineered moisture wicking materials.

Because of the large amount of moisture generated during a typical nursing shift, nurses need to ensure that their nursing shoes "air out" for at least 24 hours and are completely dry before putting them on again. A disinfectant spray to the inside of uniform shoes after each use is recommended to kill bacteria in between wearing. Having two pair of nursing shoes and alternating their usage is a good way of letting nursing footwear completely dry.

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