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I can minimize by utilizing SPF/DK/DKIM but it's not a guarantee. Services like Port25 that specialize in outbound MTA is quite expensive.
What do you guys use/suggest?
Depending on how much you're sending out and to how many people; Google Apps is a good choice.
That's pretty low for any service, and a total hassle to create a bunch of fake user accounts and keep track of how much they've sent today while round robin-ing around "as many accounts as I hope I'll need today".
In terms of specifics, I like qmail. In terms of spam management, there are lots of things to do. First and foremost, have daily monitors on all the major email providers. Get on all their feedback loops. I've found that contacting them with problems is annoying, but does work if you are following all their guidelines and are persistent about it.
cl-smtp http://www.cliki.net/CL-SMTP
I would advise doing it yourself. It isn't that hard, and assuming email is an integral part of your service, I wouldn't trust anyone else with it. In terms of specifics, I like qmail. In terms of spam management, there are lots of things to do. First and foremost, have daily monitors on all the major email providers. Get on all their feedback loops. I've found that contacting them with problems is annoying, but does…
Current stats say that our % of users who have signed up that make it through email confirmation step is about 22%.
Around 33% or so of our signups have yahoo.com addresses, and only about 12% of those manage email confirmation.
It is similarly bad for hotmail. GMail used to be quite good, but has slowly gotten worse over time.
I'd be very curious to know if others are measuring these things, and how you are doing. Feel free to contact me directly as well.