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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#991

Post by notJim »

petesergeant wrote: post #789
notJim wrote: post #416

Earlier quoted context omitted.

I'm taking saxenda, which requires a daily injection and it's totally fine. It takes like 2 minutes. The needle is tiny and most of the time you barely feel it.

How's it working for you? It's the one that's available where I live, but the reviews I've read of it have me thinking I'd be better off waiting until the newer versions come out?

I've found it super helpful. I've lost 30 lbs so far. I counting calories, but the drug makes it much easier because you're just less hungry. I didn't have any major side effects, but some people do. I plan to switch to Wegovy once it's available, though.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#992

Post by fknorangesite »

jesuscript wrote: post #852
Sophistifunk wrote: post #690

Earlier quoted context omitted.

Fat guy here: these side effects are pretty scary for somebody like me. 3 months of noticeably extra fatigue on top of my current baseline level of exhaustion seems to threaten serious psychological effects. 3 months of brain-fog sounds like a great way to get fired and really fuck up my life. If my "gastro situation" was noticeably worse than the unpredictable wildy-swinging nightmare it already is, I honestly have…

Time it properly. Pick the end of the year around December when things are slow. That knocks off a month. Save the vacation time to knock off 2 weeks in January. White knuckle it through February. You have to try something .

> Pick the end of the year around December when things are slow.

Ah yes, December: famously known for its lack of social engagements.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#993

Post by skissane »

anigbrowl wrote: post #427
sfusato wrote: post #79

> I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects. Are you for real? Serious question.

I had the same reaction. I minimize oxidative stress on my body by being selective about what I eat: having a bit less of some delicious things and eating a bit more of some boring foods that I know are good for me. Also, fuck 'longevity.' The population of the world has doubled during my lifetime and this is a Bad Thing which is wiping out vast numbers of other species. Call me misanthropic if you like but humans ar…

> I expect to live for a shorter time than my parents have (partly due to my own choices, partly environmental factors) and while that's disappointing in some ways I've been fortunate enough to enjoy reasonably good health and resultant quality of life.

What if we all live forever? https://en.wikipedia.org/wiki/Quantum_suicide_and_immortalit...

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#994

Post by archon810 »

RedditKon wrote: post #599
0xB31B1B wrote: post #21

I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…

Same - Mounjaro / Tirzeparide is nothing short of life changing. A question I often get is "how effective is it?" The SURMOUNT-1 study released in April 2022 showed 22.5% average reduction in weight for people on the highest dose of Mounjaro. For a 250 lbs person who should weigh 150 lbs (so 100 lbs of extra weight), this would result in them losing 56 lbs or 56% of their excess weight. For context, bariatric surgery…

What drug are you talking about? I did some research and I can't find it. Only talk of them ramping up Mounjaro by 2025.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#995

Post by archon810 »

machiaweliczny wrote: post #846
RedditKon wrote: post #599

Earlier quoted context omitted.

Same - Mounjaro / Tirzeparide is nothing short of life changing. A question I often get is "how effective is it?" The SURMOUNT-1 study released in April 2022 showed 22.5% average reduction in weight for people on the highest dose of Mounjaro. For a 250 lbs person who should weigh 150 lbs (so 100 lbs of extra weight), this would result in them losing 56 lbs or 56% of their excess weight. For context, bariatric surgery…

I wonder if somone studied „dragon breath” and „vacuuming” exercise vs surgery. I am 15 pounds overweight but I have a feeling that since doing these I look much better and don’t eat that much

The FDA recommended against it. https://www.fox29.com/news/fda-warns-against-eating-dragons-...

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#996

Post by ajkjk »

markus_zhang wrote: post #763
ajkjk wrote: post #517

Earlier quoted context omitted.

https://en.wikipedia.org/wiki/Set_point_theory may help > but it is thrown off hard by our modern diets. Yes. I think the dominant theory is that it has something to do with gut microbiomes, and in particular sugar and/or artificial sweeteners screw it up pretty badly.

I'm actually thinking about going serious about healing the gut microbiomes. The sugar part is the most difficult. It's very easy to eat food that helps and consume probiotics, but a life without sugar...Jesus I'd rather die. Somehow I became a sugar person from a meat person after I immigrated to Canada. Not sure what the cause was though.

I wonder what would happen if you ate so much sugar that even you started to find it gross.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#997

Post by dang »

unixbotnuke wrote: post #741

You fat fucks just eat less and go for a walk.

We've banned this account for repeatedly breaking the site guidelines.

If you don't want to be banned, you're welcome to email hn@ycombinator.com and give us reason to believe that you'll follow the rules in the future. They're here: https://news.ycombinator.com/newsguidelines.html.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#998

Post by gsinclair »

dcolkitt wrote: post #152
rajin444 wrote: post #56

This drug is a net good for society, but we have to fix the root problem. Much of the food we eat is filled with addictive ingredients (sugar, excess fats/oils, etc) that provide little nutritional value but are highly addictive. We’re subsidizing companies that create unhealthy addictive food and subsidizing companies to create drugs to counter the unhealthy addictive food. This is an enormous waste of resources.

Disagree. People genuinely enjoy those foods, because they're tasty and flavorful. And there's zero reason to believe that they're substantially unhealthy unless consumed to the point of sustained caloric surplus. We know this because we have hunter-gatherer populations who consume 50% of their diets in sugar (e.g. the Hadza) or fats (e.g. Intuit), and they have none of the diseases of abundance found in modern popul…

The existence of (active) hunter-gatherer societies living heavily on (natural) fats and sugars seems completely irrelevant to the problem of obesity in sedentary societies eating many processed foods.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#999

Post by charlieflowers »

jboy55 wrote: post #295
charlieflowers wrote: post #253

Earlier quoted context omitted.

> and the solution is to simply make more of the drug to match demand which unfortunately might not align with the incentives of capitalism.

If "Capitalism" involved the conscious coordination of all industry to maximize consumption, perhaps not. But in the terms of, raise money to buy a factory, have factory produce goods, sell goods, there seems to be a huge market for these, quite expensive, goods. edit: You could even argue, in a conspiratorial mind, that by getting people addicted to sugar ($0.0002 / mg) in order to then get them addicted to a drug t…

> edit: You could even argue, in a conspiratorial mind, that by getting people addicted to sugar ($0.0002 / mg) in order to then get them addicted to a drug that costs ($10/mg) is peak "Capitalism"

Oh you absolutely could argue that. That's pretty much right on the money. It doesn't require conspiratorial up-front planning. Just a tragedy of the commons in an environment of capitalistic incentives without the necessary constraints around it.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#1000

Post by jononomo »

astrange wrote: post #880
jononomo wrote: post #744

Earlier quoted context omitted.

Just eat only liver, eggs, and ribeye steaks -- you can absolutely stuff yourself and you will lose weight. The problem is that as a society we are sending the wrong message about what healthy food is -- nothing from a plant is really good for humans to eat. A diet of only red meat, however, will not only get you in phenomenal shape, but it will also clear up a dozen other major and minor health issues. It is the per…

Hope you don’t have hemachromatosis.

Next you'll be warning me about scurvy, lol
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