911–920 of 1001 posts
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He is basically the world's leading expert, but you can only see credentials, lol.
World leading experts usually have an impressive publishing record in the field, often a top academic research position and a long record of speaking at important global conferences on the area. Does he have all those? I'm honestly asking, I've never heard of him.
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I don't know if I'd call a veterinary anaesthetist a foremost expert on fat metabolism. His thoughts on insulin signaling are not consistent with the consensus among obesity researchers. He thinks glp-1 works through uncoupling or fat browning which is just not true. The consensus among most obesity researchers is the cause of obesity is primarily neurological, not metabolic. Basically the brain can't properly regula…
Is human metabolism really so different from other mammalian metabolism?
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.
Is it true there are plenty of places in the world that don't have an epidemic of obesity? My belief is Japan doesn't have as much of an obesity problem. Sure, I'd love a drug that lets me eat more calories and not get fat but I'd also love it if we some how managed to stop eating so many cookies, donuts, potato-chips, sugary sodas, giant portion meals, etc.... I'd also love it if we designed more areas to be walkabl…
I think the deal is that the drug suppresses your appetite so you do actually eat less
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> It’s so hard to eat healthy, I honestly cannot fathom how people do it. When I started taking semaglutide, I finally understood it. I'd eat a salad... and be full and more than satisfied! I'd look at a muffin right after lunch, and go "eh, better things to do with my time" instead of immediately having an overriding desire to eat eat eat. Before, I could eat half a pizza and still be hungry (way out of what my body…
> Too many people are convinced that everyone has the same subjective experiences of hunger and craving, but it's simply not the case. Some people implicitly hold this idea because it's a convenient ideology that allows people to morally congratulate themselves for having a functioning satiety circuit. Where does this line of thinking stop? Is everything pre-determined by genetics? Is everyone who is smarter than me,…
Well, much more is, than isn't, it seems. You may trim the sails, but life will provide you your wind direction... And in this case:
"As many as 400 genes have been shown to affect body weight in one way or another."
https://www.genomicseducation.hee.nhs.uk/blog/obesity-is-it-...
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Counting calories correctly is really hard. I've lost 90 lbs, achieved a healthy body weight, and kept it off for years, but I keep trying to lose just 10 more pounds. I only make progress when I'm religious about calorie counting, including weighing every meal or needing to do precise food prep beforehand. That's such a pain in the ass that I inevitably fail and keep returning to my body's new average weight. I thin…
Why? My sugar-free protein bars say exactly how much calories they are. I also eat some zero-calory fiber (psyllium), vitamin and minerals pills, a spoonful of fish oil, feel great and loose weight :-)
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> But it's always true that if you manage to eat fewer calories than your body needs each day you will lose weight. No, not necessarily. Several studies have shown that different people can get different amounts of energy out of the same food, depending amongst others on their gut micro biome, though stress also seems to play a role. It’s never going to be that simple. > the laws of thermodynamics won't fail Conventi…
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colon cancer rates are rising amongst everyone, even thin people. Yeah, look at all these super-old people like Alan Greenspan, Warren Buffett, Kissinger, Munger who pretty much have terrible diets, obese, no exercise yet still going strong, productive. Shows the power of genes. "Your BMI is below 23, therefore we will skip the colonoscopy and prostate/PSA exam and blood work," said no doctor ever (unless the doctor…
You might think the very rich have bad diets, but I guarantee you it's probably way better than the vast majority of people. They can and do have personal cooks, nutritionists and shoppers give them optimized food all the time and drink a coke and have a burger in public once in a while to make you think they are 'just like you and me!'. It's that underlying foundation that you don't see that gives them the margin to…
I don't buy your theory that secret to longevity is a personal chef or a nutrition expert.
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I'm also on one of these drugs (Tirzepatide) and have been for a few months. The first time I remember knowing I was fat was when a babysitter made fun of me for it at age 6. I've been fat ever since and I'm in my late 30s now. I've lost significant amounts of weight (60+ pounds) three times in my adult life, through simple calorie restriction (intermittent fasting, including before I'd ever heard the term). Every ti…
I was just saying the exact same thing to my wife yesterday. We’re both trying to lose weight, for the millionth time in the 20 years we’ve been together. Exasperated, I just said “I don’t get it. I was an artist who had no technical background, and was able to teach myself computer science and now I’m a highly successful engineer. I did that. And yet I can’t lose 10 pounds to save my life.” It’s so hard to eat healt…
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> everyone, even the skinny folks, should be on GLP1 drugs Seriously? No thanks. Think I'll give you all a few decades to see what the long-term effects are like, and let my body largely take care of itself except when specific medical issues indicate that an intervention is in order.
The only proven way to live longer and reduce your risk of essentially every disease is to reduce caloric intake. So unless you are underweight, the benefits could outweigh any side effects. I am not advocating that everyone take these drugs--but I understand why someone might suggest it
The problem with this is how a continuous caloric deficit affects your quality of life. Your body tends to adapt by making you feel tired and killing your libido. Not to mention that being underweight becomes a health hazard past a certain age.
IMO, if you aren't overweight, eating a healthy diet and enough calories to maintain your weight will give you the best combination of longevity and durability.