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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#901

Post by chess_buster »

kergonath wrote: post #825
fortran77 wrote: post #718

Earlier quoted context omitted.

[flagged]

> But it's always true that if you manage to eat fewer calories than your body needs each day you will lose weight. No, not necessarily. Several studies have shown that different people can get different amounts of energy out of the same food, depending amongst others on their gut micro biome, though stress also seems to play a role. It’s never going to be that simple. > the laws of thermodynamics won't fail Conventi…

I told myself this as well, but as an anecdote: I started to lose weight from counting each and every calorie and never exceeding the exact amount my weight-trainer set for me.

What did I eat? Fries, Pizza, Chocolate, Burger, … still lost weight.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#902

Post by chess_buster »

SamPatt wrote: post #805
fortran77 wrote: post #718

Earlier quoted context omitted.

[flagged]

Counting calories correctly is really hard. I've lost 90 lbs, achieved a healthy body weight, and kept it off for years, but I keep trying to lose just 10 more pounds. I only make progress when I'm religious about calorie counting, including weighing every meal or needing to do precise food prep beforehand. That's such a pain in the ass that I inevitably fail and keep returning to my body's new average weight. I thin…

This is the insight of the day. I have to save your comment for later reference.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#903

Post by fsflover »

plopz wrote: post #539
uhtred wrote: post #490

Earlier quoted context omitted.

> Nutrition and fitness are classic examples of pseudo-science I think it's pretty well agreed upon in the medical community (and proven) that a healthy diet (lots of fruit and vegetables, not too much sugar, etc) and regular exercise leads to better health. It's not pseudo-science. Neither is the statement that consuming more calories than you burn will make you put on weight.

is fruit still considered healthy? i thought they ditched those alongside veg like potatoes and corn

https://www.hsph.harvard.edu/nutritionsource/what-should-you...

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#904

Post by refurb »

jononomo wrote: post #757
JamesBarney wrote: post #548

Earlier quoted context omitted.

I don't know if I'd call a veterinary anaesthetist a foremost expert on fat metabolism. His thoughts on insulin signaling are not consistent with the consensus among obesity researchers. He thinks glp-1 works through uncoupling or fat browning which is just not true. The consensus among most obesity researchers is the cause of obesity is primarily neurological, not metabolic. Basically the brain can't properly regula…

He is basically the world's leading expert, but you can only see credentials, lol.

World leading experts usually have an impressive publishing record in the field, often a top academic research position and a long record of speaking at important global conferences on the area.

Does he have all those? I'm honestly asking, I've never heard of him.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#905

Post by YellOh »

Auracle wrote: post #812
rootusrootus wrote: post #537

Earlier quoted context omitted.

> discipline and hard work (or genetic luck) Let me tell you, the number of thin people I've met who got there through discipline and hard work is vanishingly small compared to those genetically blessed. This is probably why it's such an appealing delusion -- who doesn't want the world to think they're disciplined and hardworking, instead of just lucky?

How do you know they got it through being "genetically blessed" and not just...putting the fork down? In my experience a lot of skinny people don't outwardly signal that they're "dieting" because they're literally always dieting.

Being able to easily put the fork down / always dieting is the genetic blessing. Some people maintain a low weight with almost no effort, while the genetically unlucky seem to be hardwired to always be craving food & would subjectively suffer a lot more to eat like the naturally skinny.

I'm full (and would get nauseated if I continued eating) with an amount of food that would leave my sibling still feeling constant hunger pangs... the feeling of "fullness" here is the genetic/hormonal blessing

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#906

Post by nervousvarun »

narrator wrote: post #709

The big elephant in the room is where did everyone's endogenous GLP-1 peptide go? A similar elephant in the room is why is synthetic thyroid hormone to replace all the missing endogenous thyroid hormones such a high selling drug? What in the environment is slowly poisoning everyone so their bodies don't work normally? Here's a clue, one of hundreds in the medical literature: "The endocrine disrupting potential of mon…

Very interesting post but aren't obesity rates similarly increasing in EU countries?

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#907

Post by ffggvv »

dcolkitt wrote: post #152
rajin444 wrote: post #56

This drug is a net good for society, but we have to fix the root problem. Much of the food we eat is filled with addictive ingredients (sugar, excess fats/oils, etc) that provide little nutritional value but are highly addictive. We’re subsidizing companies that create unhealthy addictive food and subsidizing companies to create drugs to counter the unhealthy addictive food. This is an enormous waste of resources.

Disagree. People genuinely enjoy those foods, because they're tasty and flavorful. And there's zero reason to believe that they're substantially unhealthy unless consumed to the point of sustained caloric surplus. We know this because we have hunter-gatherer populations who consume 50% of their diets in sugar (e.g. the Hadza) or fats (e.g. Intuit), and they have none of the diseases of abundance found in modern popul…

the problem is you are limited in how many calories you can consume. so any unhealthy crap crowds out nutrient rich stuff

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#908

Post by refurb »

narrator wrote: post #709

The big elephant in the room is where did everyone's endogenous GLP-1 peptide go? A similar elephant in the room is why is synthetic thyroid hormone to replace all the missing endogenous thyroid hormones such a high selling drug? What in the environment is slowly poisoning everyone so their bodies don't work normally? Here's a clue, one of hundreds in the medical literature: "The endocrine disrupting potential of mon…

MSG is very common in Asia and has been for a while (you can buy it in 1 kg bags) yet Asia has low obesity.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#909

Post by YellOh »

2devnull wrote: post #491

“when lifestyle changes aren’t enough.” People don’t want to hear it, but we do nobody any favors by pretending this is more complicated than it is. It’s actually pretty simple. The solution is to adjust calories in vs calories out. Fast a few days a week. Cut out bread, sugar and other simple carbs. We don’t help alcoholics or opioid addicts by enabling them with statements like “when not getting drunk isn’t enough……

We actually do often recognize that "just stop having problems" isn't usually useful advice for people with drug addiction, too. Ex. naltrexone for alcohol addiction, methadone for opioid addiction, etc. "Just stop having problems" is usually easy to say as an outside observer, but generally when someone's reward circuit is hijacked by addiction, it takes something more effective to rewire it. Sometimes sheer willpower is enough to exit the cycle, but usually it takes outside changes (drugs, environmental changes, effective therapy) to loosen the grip of addiction.
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