In another HN thread about this AlphaGenome Atlas, someone has posted a link to: https://www.science.org/content/blog-post/mutate-em-all-and-... which comments the results of this study: https://www.biorxiv.org/content/10.64898/2026.07.25.740675v1 That study has done in reality what the AlphaGenome Atlas does in fiction, but instead for a human they have done it for one of the simplest viruses. So they have fuzzed th…
AlphaGenome Atlas: a high-resolution map of human DNA
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Re: AlphaGenome Atlas: a high-resolution map of human DNA
#92Re: AlphaGenome Atlas: a high-resolution map of human DNA
#93Earlier quoted context omitted.
Google Streetview/maps isn't even the best mapping/'streetview' tool at this point. Filled with ads and bugs, some major bugs have been there for 10+ years.
Now I'm curious. What is the better mapping and streetview tool at this point?
I believe Google has been trying to improve their Streetview in coverage as apple has become a concurrent, but it still has the same bugs people have been complaining about for years (like going backward when pressing forward type of bad). If I remember correctly the bugs have been 'closed' or something before just to include it in the same slightly different way.
Re: AlphaGenome Atlas: a high-resolution map of human DNA
#94Re: AlphaGenome Atlas: a high-resolution map of human DNA
#95Can this be used with a 23andMe genome to find pathogenic mutations?
23andMe and similar companies don't transcribe your entire genome because that would cost way more than they charge you. They just sample a few tiny sections of it.
23andMe used a custom Illumina Infinium microarray designed around segments of particular interest.
Re: AlphaGenome Atlas: a high-resolution map of human DNA
#96Earlier quoted context omitted.
It's "shareholder-linked" (probably not "driven"), but yes, upvoted. Nonetheless, even when with grave faults in the path, Google has managed to give us marvellous, paramount free resources (Google Street, Google Museum...), and would have given more (Google Books - if the negotiation had succeeded). I am grateful.
Why would you be grateful? I don't think any of that should be under private control to begin with.
Looking at current hot problems, and exemplary of the situation: which public entities have endeavoured to backup the most important channels and videos from YouTube, the current historic video archive?
Why would I be grateful?! Because somebody did create those resources and made them available! And they did to common good (if anybody refused the expression "for" common good).
Re: AlphaGenome Atlas: a high-resolution map of human DNA
#97Earlier quoted context omitted.
Mob rule, aka Democracy.
Not what democracy is. Every single serious theorist of democracy has recognized this. Democracy is about rule of law and institutions, not simply the mob. Tyranny of the majority is the paramount concern of all democracies. Nevertheless, institutions can fail. The idea that democracy always leads to desirable outcomes is evidently false by historical record. I just don't understand people who think the state is bett…
Trump does have a say in how to run google, in a very real sense.
> The American mob seems intent on leading their country into the gutter. Good thing (despite what the mob has thrown at it) that the United States still has strong institutions and strong markets. Without Silicon Valley, America would have already lost its place on the world stage.
American elites are more than happy to follow basically whatever Trump wants them to do with the knowledge that they'll get preferential treatment by the law and win all the no-bid contracts he can award. But ask yourself if this would be any different if Trump were head of a large company under a smaller regulatory state. Seems pretty obvious that not much would change.
If by "the mob" you mean, a small cohort of wealthy, powerful, unscrupulous people, those people who make decisions that the rest of us have no say in, then I agree, that is a problem.
> But please lets hear more indictments from a population who can't even agree with itself on the issues already under the government's purview. Now let's set a precedent for even more state interference in the market, that way when your party (whatever side you are on) chokes the next future election away the next nut you don't agree with has even more power? Is that your plan?
In a smaller state, Trump would have continued to be an executive and the shape of his impact on the world might be slightly different, but would be no less oppressive. Ask tenants in NYC in the 1980s if they think a Donald Trump with smaller regulatory oversight who stayed in business would be better or worse for our country.
Do you think our country flips parties every year because our government does a good job of reflecting the will of the people?
Re: AlphaGenome Atlas: a high-resolution map of human DNA
#98People are upvoting this because it has the “Alpha______” prefix. Meanwhile, everyone in the field of genomics knows that AlphaGenome provides essentially zero improvements over the previous SOTA, Borzoi…
Can you elaborate on this? I'm confused why Google would build something that provides zero improvements over SOTA, Borzoi... as you mention. I'm not familiar with this field, just curious.
Re: AlphaGenome Atlas: a high-resolution map of human DNA
#99Can this be used with a 23andMe genome to find pathogenic mutations?
It's unlikely that they would luck into testing some unknown SNP which turned out to be relevant for disease.
Re: AlphaGenome Atlas: a high-resolution map of human DNA
#100Can this be used with a 23andMe genome to find pathogenic mutations?
23andMe and similar companies don't transcribe your entire genome because that would cost way more than they charge you. They just sample a few tiny sections of it.