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AlphaGenome Atlas: a high-resolution map of human DNA

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Re: AlphaGenome Atlas: a high-resolution map of human DNA

#91

In another HN thread about this AlphaGenome Atlas, someone has posted a link to: https://www.science.org/content/blog-post/mutate-em-all-and-... which comments the results of this study: https://www.biorxiv.org/content/10.64898/2026.07.25.740675v1 That study has done in reality what the AlphaGenome Atlas does in fiction, but instead for a human they have done it for one of the simplest viruses. So they have fuzzed th…

Yep. Sequence-to-function models are still very limited. AlphaGenome Atlas, despite the flashy branding, is unlikely to provide significant benefit to researchers.

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#93

Earlier quoted context omitted.

Google Streetview/maps isn't even the best mapping/'streetview' tool at this point. Filled with ads and bugs, some major bugs have been there for 10+ years.

Now I'm curious. What is the better mapping and streetview tool at this point?

For maps there's quite a few, just anything that doesn't have the amount of ads beats it. For Streetview apple lookaround is a better experience if it's mapped well in your area.

I believe Google has been trying to improve their Streetview in coverage as apple has become a concurrent, but it still has the same bugs people have been complaining about for years (like going backward when pressing forward type of bad). If I remember correctly the bugs have been 'closed' or something before just to include it in the same slightly different way.

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#95

Can this be used with a 23andMe genome to find pathogenic mutations?

23andMe and similar companies don't transcribe your entire genome because that would cost way more than they charge you. They just sample a few tiny sections of it.

A few as in tens of thousands.

23andMe used a custom Illumina Infinium microarray designed around segments of particular interest.

https://www.illumina.com/products/by-brand/infinium.html

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#96
post #21

Earlier quoted context omitted.

It's "shareholder-linked" (probably not "driven"), but yes, upvoted. Nonetheless, even when with grave faults in the path, Google has managed to give us marvellous, paramount free resources (Google Street, Google Museum...), and would have given more (Google Books - if the negotiation had succeeded). I am grateful.

Why would you be grateful? I don't think any of that should be under private control to begin with.

And which public enterprise has undertaken those projects?

Looking at current hot problems, and exemplary of the situation: which public entities have endeavoured to backup the most important channels and videos from YouTube, the current historic video archive?

Why would I be grateful?! Because somebody did create those resources and made them available! And they did to common good (if anybody refused the expression "for" common good).

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#97

Earlier quoted context omitted.

Mob rule, aka Democracy.

Not what democracy is. Every single serious theorist of democracy has recognized this. Democracy is about rule of law and institutions, not simply the mob. Tyranny of the majority is the paramount concern of all democracies. Nevertheless, institutions can fail. The idea that democracy always leads to desirable outcomes is evidently false by historical record. I just don't understand people who think the state is bett…

> Should Donald Trump get a say in how to run Google?

Trump does have a say in how to run google, in a very real sense.

> The American mob seems intent on leading their country into the gutter. Good thing (despite what the mob has thrown at it) that the United States still has strong institutions and strong markets. Without Silicon Valley, America would have already lost its place on the world stage.

American elites are more than happy to follow basically whatever Trump wants them to do with the knowledge that they'll get preferential treatment by the law and win all the no-bid contracts he can award. But ask yourself if this would be any different if Trump were head of a large company under a smaller regulatory state. Seems pretty obvious that not much would change.

If by "the mob" you mean, a small cohort of wealthy, powerful, unscrupulous people, those people who make decisions that the rest of us have no say in, then I agree, that is a problem.

> But please lets hear more indictments from a population who can't even agree with itself on the issues already under the government's purview. Now let's set a precedent for even more state interference in the market, that way when your party (whatever side you are on) chokes the next future election away the next nut you don't agree with has even more power? Is that your plan?

In a smaller state, Trump would have continued to be an executive and the shape of his impact on the world might be slightly different, but would be no less oppressive. Ask tenants in NYC in the 1980s if they think a Donald Trump with smaller regulatory oversight who stayed in business would be better or worse for our country.

Do you think our country flips parties every year because our government does a good job of reflecting the will of the people?

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#98

People are upvoting this because it has the “Alpha______” prefix. Meanwhile, everyone in the field of genomics knows that AlphaGenome provides essentially zero improvements over the previous SOTA, Borzoi…

> Meanwhile, everyone in the field of genomics knows that AlphaGenome provides essentially zero improvements over the previous SOTA, Borzoi…

Can you elaborate on this? I'm confused why Google would build something that provides zero improvements over SOTA, Borzoi... as you mention. I'm not familiar with this field, just curious.

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#99

Can this be used with a 23andMe genome to find pathogenic mutations?

Probably not any 23andMe haven't already told you about. They test a limited set of SNPs, balancing between ones thought useful for genealogy, ones useful for ethnicity estimates and ones thought useful for health-related things (the latter they would like to make their main selling point, the two former are really all commercial DNA services' bread and butter).

It's unlikely that they would luck into testing some unknown SNP which turned out to be relevant for disease.

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#100

Can this be used with a 23andMe genome to find pathogenic mutations?

23andMe and similar companies don't transcribe your entire genome because that would cost way more than they charge you. They just sample a few tiny sections of it.

fwiw sequencing your entire genome only costs $400 or so from providers like sequencing.com
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