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Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#91

Post by SideburnsOfDoom »

ryan_n wrote: post #89
dosisking wrote: post #76

Earlier quoted context omitted.

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Would love to see a source for this, but I'm assuming you don't have one and are just spreading FUD due to your political beliefs... Closest thing I could find was a little over 15,000 people in Europe who got myocarditis (also includes pericarditis: https://pmc.ncbi.nlm.nih.gov/articles/PMC10746454/ ). Out of millions (hundreds of millions?) that received the vaccine. Please stop doing what your doing. It's pretty s…

> Please stop doing what your doing

Yes, and it's worse than that for the parent commenter, the unvaccinated population also got some cases of myocarditis - often after Covid. And they got myocarditis at a higher rate than the vaccinated.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#92

Post by estearum »

Argonaut998 wrote: post #80
lern_too_spel wrote: post #43

Earlier quoted context omitted.

What's more, they found that myocarditis risk was higher in the unvaccinated population after infection. This information didn't get to the so-called "skeptics," who willfully ignored data that didn't fit their conspiracy theory. https://www.heart.org/en/news/2022/08/22/covid-19-infection-...

>In men younger than 40 years old, the number of excess myocarditis events per million people was higher after a second dose of mRNA-1273 than after a positive SARS-CoV-2 test (97 [95% CI, 91–99] versus 16 [95% CI, 12–18]). From your own study you linked. The first comment I ever posted on HN was regarding a similar study where there was no control group whatsoever for unvaccinated people. I can’t get over the sunk c…

Let's assume that it's correct that "no one who was not immunocompromised should have ever taken it." (It's not, but let's assume that it is)

Was this knowably true in Q1 2021?

Can you please share the specific, contemporaneously available information that made this knowably true?

If you can't, then it's not "sunk cost" infecting someone else's thinking, it's hindsight bias infecting yours.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#93

Post by paulpauper »

GenerWork wrote: post #4

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

melanoma , unlike the others, has a much weaker link to sun exposure. its why melanoma often appear in areas with no sun exposure

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#94

Post by dosisking »

declan_roberts wrote: post #19
Someone1234 wrote: post #13

Earlier quoted context omitted.

> For all the hate I have for the COVID vaccine Can you clarify that? It saved 100K+ lives even by incredibly conservative estimates, and allowed life to returned to normal at least a year earlier than otherwise.

I can't speak for other people but I was upset to enter a medical era where bureaucrats were forcing medical decisions on me. I was forced to get it or lose my job despite 1) working remotely, 2) having already had Covid and 3) being healthy and not at risk of Covid death but being the largest risk for myocarditis.

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#95

Post by paulpauper »

danjl wrote: post #69

Will this targeted approach be beneficial to other cancer types? Is there any data or theory about this class of drugs as a more general therapy?

Individualized immune cancer therapy has been touted as the next big thing for half a century. It's nothing new, and with few exceptions, such as skin cancer, has failed to yield much. scientists, for decades, have tired to harness the immune system to attackcancer and it almost never works.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#96

Post by redsocksfan45 »

Insanity wrote: post #21
GenerWork wrote: post #4

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

+1. Also, just to call out, it doesn't need to be _warm_ for you to need sunblock. Even when it's cooler / cloudier out there you can still get skin damage. Look for UV rating rather than temperature. Conversely, it being hot doesn't imply high-UV either.

[dead]

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#97

Post by addisonl »

Noaidi wrote: post #55
anonymars wrote: post #37

Earlier quoted context omitted.

Article: " two forms of rare melanoma are not caused by exposure to the sun.." > Most skin cancers are not a big deal, and even Melanomas can vanish on their own PSA: don't take medical advice from internet comments

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> This also means that you are likely to get melenoma form something other than the sun.

Quantifiably false statement. Incredibly dangerous misinformation to spread—shame on you.

From https://onlinelibrary.wiley.com/doi/10.1002/ijc.35463

> Cutaneous melanoma (CM) accounted for around 331,700 cancer cases globally in 2022

> An estimated 267,353 (95% uncertainty intervals [UI]: 242,818, 278,638) CM cases were UVR attributable globally in 2022

UVR = Ultraviolet radiation

Cutaneous melanoma (CM) is the vast majority of melanoma cases in the US at least:

> The percentages of melanomas that were cutaneous, ocular, mucosal, and unknown primaries were 91.2%, 5.2%, 1.3%, and 2.2%, from https://pubmed.ncbi.nlm.nih.gov/9781962/

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#99

Post by paulpauper »

consumer451 wrote: post #8

This appears to be a potentially huge win for health. The market has Moderna up 153% at time of writing, which is some sort of validation I suppose. Related stories: https://www.fiercebiotech.com/biotech/merck-and-modernas-per... https://www.reuters.com/legal/litigation/merck-moderna-say-m... https://www.wsj.com/health/pharma/moderna-merck-vaccine-succ...

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