Weight loss jabs: What happens when you stop taking them • Hacker News Board

Re: Weight loss jabs: What happens when you stop taking them

#91

Post by nradov » Mon, Dec 22, 2025, 1:09 AM UTC

jmward01 wrote: post #8

Other medications become lifelong medications but without this level of scrutiny. I am 100% in favor of finding a more permanent treatment, but switching blood pressure meds, and cholesterol meds, and other daily meds for a single once a week med is a massive improvement, especially since the all source mortality data keeps rolling in showing the efficacy here is orders of magnitude better than all the other medicati…

I doubt that willpower or lack thereof is a significant factor. It's more a matter of habits and discipline. Willpower can allow you to resist temptation for a few hours but it's not sustainable.

I know several people who were formerly obese and have achieved sustained weight loss without drugs or surgery. The common factor seems to be that they "hit rock bottom", sort of like a drug addict, and decided to make permanent lifestyle changes in order to survive and stop letting down those who depended upon them. These lifestyle changes are often pretty drastic, and involve more than just eating less and exercising more.

If people want to take GLP-1 drugs and understand the risks then I have no problem with that and don't see it as a moral failing. But they might want to evaluate whether this is just masking the symptoms of some deeper mental health condition.

Re: Weight loss jabs: What happens when you stop taking them

#92

Post by nradov » Mon, Dec 22, 2025, 1:12 AM UTC

paulpauper wrote: post #62

manmal wrote: post #51

Earlier quoted context omitted.

Congrats, your metabolism (FAO, gluconeogenesis, insulin sensitivity, …) works well. Don’t assume that’s the case for everyone, because it’s well researched that this is highly individual.

The ability to tolerate discomfort is probably as genetic/inante as metabolism.

Why would we think that? Tolerating discomfort seems to be a skill that anyone can develop with deliberate practice. Perhaps genetics imposes some upper limit, but just like in sports most people never put in the work necessary to even approach their genetic limit.

https://eastermichael.com/book/

It's winter in the Northern hemisphere right now. Try going for a walk tomorrow deliberately undressed to the point that you're deeply uncomfortable but not risking serious injury or death. Anyone can do this, and over time it makes tolerating other forms of discomfort easier.

Re: Weight loss jabs: What happens when you stop taking them

#93

Post by DamnInteresting » Mon, Dec 22, 2025, 1:26 AM UTC

AaronAPU wrote: post #33

jmward01 wrote: post #8

Other medications become lifelong medications but without this level of scrutiny. I am 100% in favor of finding a more permanent treatment, but switching blood pressure meds, and cholesterol meds, and other daily meds for a single once a week med is a massive improvement, especially since the all source mortality data keeps rolling in showing the efficacy here is orders of magnitude better than all the other medicati…

But it is factually true that it’s a matter of willpower, no amount of reframing it is going to change that. It’s not like others like myself, currently on a cut cycle, don’t experience hunger. The idea that we are just “lucky” ignores all the willpower and discipline we fight through to do it ourselves. I’ve eaten about 800 calories today and it is 4pm. Just finished 90 minutes on the indoor bike. My stomach feels h…

Oh, you can't reach the items on the higher grocery shelves no matter how hard you stretch? That's just a deficit of tall-power. I also experience items on high shelves. No, you shouldn't use a stepping stool to grab those items; just stretch more, and grow taller, like me! Look how good I am at being a bit taller than you! Your failure to be slightly taller is a character flaw, feel bad.

Re: Weight loss jabs: What happens when you stop taking them

#94

Post by nradov » Mon, Dec 22, 2025, 1:28 AM UTC

pton_xd wrote: post #85

jchw wrote: post #19

Earlier quoted context omitted.

It's frustrating. "Just Eat Less" is roughly the way to lose weight, but the problem is not that fat people are so unbelievably stupid that they didn't know this. I am sure for some people it really is that simple. Not us. My weight has been a bit of a rollercoaster. I've never been terribly thin, but I've been "not technically obese" from time to time. I'm currently back on the downswing, but God, what a pain in the…

> "Just Eat Less" is roughly the way to lose weight Maybe the messaging should be "eat healthier"? How many obese people cook for themselves and eat exclusively from the outer aisles of the grocery (fruits, vegetables, seafood, meat, eggs, dairy)? I could be wrong but I have to imagine the average obese person has a terrible diet. Portion control won't work at that point, you're already doomed to fail. To be fair, mo…

Differences in metabolism are very seldom the real reason. The people who claim they have a "slow" or "fast" metabolism can't back that up with actual RMR test results. They're just bad at estimating many calories they actually consume. This can go both ways.

Re: Weight loss jabs: What happens when you stop taking them

#95

Post by nradov » Mon, Dec 22, 2025, 1:34 AM UTC

true2octave wrote: post #88

skrebbel wrote: post #17

Earlier quoted context omitted.

How many years have you been able to keep that diet up?

Particularly eating a lot of eggs daily for about 3 years

The Time Magazine cover story in 1984 where they falsely claimed that consuming cholesterol from eggs and other sources was dangerous was a real turning point. That misunderstanding has caused tremendous harm to public health for decades. I think the journalists acted in good faith but they believed junk science.

https://time.com/archive/6855517/hold-the-eggs-and-butter/

https://content.time.com/time/specials/2007/article/0,28804,...

Re: Weight loss jabs: What happens when you stop taking them

#96

Post by pandaman » Mon, Dec 22, 2025, 1:39 AM UTC

paulpauper wrote: post #52

filoleg wrote: post #41

Earlier quoted context omitted.

> It feels like gaining weight is incredibly easy and losing it is incredibly hard I feel like there is more to it. Obviously, I sympathize with you, and I noticed that when I switch from a bulking cycle to a cutting cycle, it is a bit difficult to adjust for the first couple of weeks as well. But by god, I truly am struggling to switch the other way around, and it takes me months to adjust to the bulking cycle, even…

But by god, I truly am struggling to switch the other way around, and it takes me months to adjust to the bulking cycle, even with the help of stuff like weed You could just have good genetics in which your body is resistant to weight gain or you have a low appetite to begin with. As shown by the worldwide obesity epidemic, this is apparently quite an uncommon problem. 75% of country overweight or obese.

If normal resistance to weight gain or appetite lead to 35+ BMI then we would not have had the obesity epidemic, it would be just normal state for humans to be 200+ lbs weight just like it's normal to be under 7' height.

Re: Weight loss jabs: What happens when you stop taking them

#97

Post by nradov » Mon, Dec 22, 2025, 1:40 AM UTC

asciimov wrote: post #15

> "The environment that people live in needs to be one that promotes health, not weight gain. […] Obesity is not a GLP-1 deficiency," he says. This is my biggest issue with weight healthcare, the idea that if only the patient would eat correctly they wouldn’t be overweight. It’s not some moral failing a person often over eats, it very well could be some physiological issue that should be treated. It would be like tel…

Some people have literally been able able to overcome asthma — or at least significantly reduce symptoms — by learning to breathe better. Getting in better physical shape can be part of this. That doesn't necessarily work for all patients but at least some have been successful.

https://www.penguinrandomhouse.com/books/547761/breath-by-ja...

Re: Weight loss jabs: What happens when you stop taking them

#98

Post by diziet » Mon, Dec 22, 2025, 4:21 AM UTC

lr4444lr wrote: post #83

asciimov wrote: post #15

> "The environment that people live in needs to be one that promotes health, not weight gain. […] Obesity is not a GLP-1 deficiency," he says. This is my biggest issue with weight healthcare, the idea that if only the patient would eat correctly they wouldn’t be overweight. It’s not some moral failing a person often over eats, it very well could be some physiological issue that should be treated. It would be like tel…

As someone with asthma, let me tell you that they _do_ need to get into better shape to breathe better. Part of that is a medically proven practice called pulmonary rehabilitation, but also, regular cardiovascular exercise at different intensities and direct training of the abdominal muscles has a marked improvement both on pulmonary function (to a limit, but even more important as you age) and oxygen utilization fro…

Thank you for sharing this and elaborating on what I've seen firsthand. Another thing we've noticed is that an increase in VO 2 Max, which does take quite a bit of time to change, makes a major difference.

Altitude is another factor, due to dry and colder air and lower oxygen -- a double whammy for asthma.

Re: Weight loss jabs: What happens when you stop taking them

#99

Post by daft_pink » Mon, Dec 22, 2025, 4:23 AM UTC

I basically just gained the weight back again.

I missed doses long enough that I had to start at the beginning, but I avoided that because I had to book and appointment with my doctor and get prescribed the lower dose, etc.

So I gained the weight all back and then lose it again when I got back on the doses.

Re: Weight loss jabs: What happens when you stop taking them

#100

Post by seba_dos1 » Mon, Dec 22, 2025, 4:55 AM UTC

AaronAPU wrote: post #33

jmward01 wrote: post #8

Other medications become lifelong medications but without this level of scrutiny. I am 100% in favor of finding a more permanent treatment, but switching blood pressure meds, and cholesterol meds, and other daily meds for a single once a week med is a massive improvement, especially since the all source mortality data keeps rolling in showing the efficacy here is orders of magnitude better than all the other medicati…

But it is factually true that it’s a matter of willpower, no amount of reframing it is going to change that. It’s not like others like myself, currently on a cut cycle, don’t experience hunger. The idea that we are just “lucky” ignores all the willpower and discipline we fight through to do it ourselves. I’ve eaten about 800 calories today and it is 4pm. Just finished 90 minutes on the indoor bike. My stomach feels h…

I don't think my ability to sit with hunger without fainting or experiencing massive headaches is due to my willpower. Fortunately, at least I'm not ignorant about it and don't write comments like yours.