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Weight loss jabs: What happens when you stop taking them

bbc.com

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Re: Weight loss jabs: What happens when you stop taking them

#11

Post by true2octave »

OptionOfT wrote: post #6

Being overweight is a chronic disease. Just like alcoholism, or any kind of other addictions. I've struggled with alcohol abuse, and once you come to the realization that you're abusing it, the fix FOR ME was relatively simple: I stopped (under medical supervision) drinking, or to be more precise: I stopped starting to drink. I have no problems not drinking, I have a problem that when I start I cannot stop. I have th…

What works for me is to eat highly nutritious low-glycemic food until I feel full (eggs, avocado, quinoa, etc)

Otherwise I over eat crap and gain weight easily

Re: Weight loss jabs: What happens when you stop taking them

#12

Post by Taikonerd »

Interesting link: a company called Fractyl Health is studying a surgical procedure they call "Revita," that they hope can keep weight off for patients after they discontinue GLP-1s.[0]

The premise, IIUC, is that obesity is driven partly by mucosal overgrowth on the duodenum. This thicker-than-expected layer of mucus is less porous, which leads your digestive system to underestimate the number of calories you've consumed. Revita basically re-surfaces the duodenum.

So, the idea is that you get to a lower weight with the GLP-1 drugs, and then Revita can hopefully reset your set point there.

Their first clinical trial is still in progress, but I think it's interesting to watch.

[0]: https://www.fractyl.com/our-platforms/revita/

Re: Weight loss jabs: What happens when you stop taking them

#13

Post by isoprophlex »

belter wrote: post #2

TLDR: "...evidence so far suggests that, between one and three years after stopping the medication, people will see a "significant proportion of weight" go back on...Somewhere in the region of 60 to 80% of the weight that you lost will return..."

Taking recovered drug addicts and placing them in a situation where everyone's using all the time would probably lead to equally bad outcomes.

Our food is too rich in calories, too abundantly available, and too addictive for most people.

Re: Weight loss jabs: What happens when you stop taking them

#14

Post by 3rodents »

jmward01 wrote: post #8

Other medications become lifelong medications but without this level of scrutiny. I am 100% in favor of finding a more permanent treatment, but switching blood pressure meds, and cholesterol meds, and other daily meds for a single once a week med is a massive improvement, especially since the all source mortality data keeps rolling in showing the efficacy here is orders of magnitude better than all the other medicati…

I don’t think that’s a fair assessment. I’m all for life-long drugs that help with weight loss, I don’t view it as a moral failing. That said, it is easy to see why so many people are concerned about these drugs: people taking them can look terrible (“ozempic face”). Gaunt, sick, hollowed out, look at people like Sharon Osbourne, that’s the public face of these drugs. And so when people are committing to life-long use of these drugs, it is being viewed with the very visible side effects in mind, and that is concerning to a lot of people after these drugs seemingly appeared overnight.

Re: Weight loss jabs: What happens when you stop taking them

#15

Post by asciimov »

> "The environment that people live in needs to be one that promotes health, not weight gain. […] Obesity is not a GLP-1 deficiency," he says.

This is my biggest issue with weight healthcare, the idea that if only the patient would eat correctly they wouldn’t be overweight. It’s not some moral failing a person often over eats, it very well could be some physiological issue that should be treated. It would be like telling someone with asthma that they just need to get into better shape to breathe better.

Re: Weight loss jabs: What happens when you stop taking them

#16

Post by harvey9 »

Taikonerd wrote: post #12

Interesting link: a company called Fractyl Health is studying a surgical procedure they call "Revita," that they hope can keep weight off for patients after they discontinue GLP-1s.[0] The premise, IIUC, is that obesity is driven partly by mucosal overgrowth on the duodenum. This thicker-than-expected layer of mucus is less porous, which leads your digestive system to underestimate the number of calories you've consu…

Surprised this is still in first trial. I can recall reading about something like it in 2017. Apparently clearing the duodenal mucosa is a preparatory step for a gastric band fitting, but they found patients were making improvements before the bands were being fitted so a study was started to see if this less invasive procedure might be enough by itself.

Re: Weight loss jabs: What happens when you stop taking them

#17

Post by skrebbel »

true2octave wrote: post #11
OptionOfT wrote: post #6

Being overweight is a chronic disease. Just like alcoholism, or any kind of other addictions. I've struggled with alcohol abuse, and once you come to the realization that you're abusing it, the fix FOR ME was relatively simple: I stopped (under medical supervision) drinking, or to be more precise: I stopped starting to drink. I have no problems not drinking, I have a problem that when I start I cannot stop. I have th…

What works for me is to eat highly nutritious low-glycemic food until I feel full (eggs, avocado, quinoa, etc) Otherwise I over eat crap and gain weight easily

How many years have you been able to keep that diet up?

Re: Weight loss jabs: What happens when you stop taking them

#18

Post by hamandcheese »

3rodents wrote: post #14
jmward01 wrote: post #8

Other medications become lifelong medications but without this level of scrutiny. I am 100% in favor of finding a more permanent treatment, but switching blood pressure meds, and cholesterol meds, and other daily meds for a single once a week med is a massive improvement, especially since the all source mortality data keeps rolling in showing the efficacy here is orders of magnitude better than all the other medicati…

I don’t think that’s a fair assessment. I’m all for life-long drugs that help with weight loss, I don’t view it as a moral failing. That said, it is easy to see why so many people are concerned about these drugs: people taking them can look terrible (“ozempic face”). Gaunt, sick, hollowed out, look at people like Sharon Osbourne, that’s the public face of these drugs. And so when people are committing to life-long us…

"Ozempic face" is actually just "unhealthy rapid weight loss face". Ozempic makes it easier to starve yourself, but that isn't how it's supposed to be used.

Re: Weight loss jabs: What happens when you stop taking them

#19

Post by jchw »

OptionOfT wrote: post #6

Being overweight is a chronic disease. Just like alcoholism, or any kind of other addictions. I've struggled with alcohol abuse, and once you come to the realization that you're abusing it, the fix FOR ME was relatively simple: I stopped (under medical supervision) drinking, or to be more precise: I stopped starting to drink. I have no problems not drinking, I have a problem that when I start I cannot stop. I have th…

It's frustrating.

"Just Eat Less" is roughly the way to lose weight, but the problem is not that fat people are so unbelievably stupid that they didn't know this. I am sure for some people it really is that simple. Not us.

My weight has been a bit of a rollercoaster. I've never been terribly thin, but I've been "not technically obese" from time to time. I'm currently back on the downswing, but God, what a pain in the ass. It feels like gaining weight is incredibly easy and losing it is incredibly hard (and I do believe this is validated by the science, because you wind up with more fat cells when you first gain weight, which I guess is both relieving and terrifying.)

No matter how many attempts it takes to fix my body, I'm obviously going to just keep trying, because obesity is horrible for you in so many ways. It saps your energy, it's carcinogenic, it increases your blood pressure and risk of heart disease, but it feels like one of those struggles that is never-ending. I've improved my diet numerous times but it never feels like it's quite enough.

Re: Weight loss jabs: What happens when you stop taking them

#20

Post by kiba »

asciimov wrote: post #15

> "The environment that people live in needs to be one that promotes health, not weight gain. […] Obesity is not a GLP-1 deficiency," he says. This is my biggest issue with weight healthcare, the idea that if only the patient would eat correctly they wouldn’t be overweight. It’s not some moral failing a person often over eats, it very well could be some physiological issue that should be treated. It would be like tel…

Until we are able to fix the environment and culture, we're stuck with medications like this. The good news is that glp1 medicine can be used to break addictive behaviors, so it is the very tool that can help change our environment by reducing demand for junk food.

We still need to talk to our Congress critters.

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