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I'm curious if there is a basic set of tests you can do with drinking locally to know one way or the other, as well?
Measure your blood pressure. Measure before consumption. Take three different readings. Measure at one hour intervals after caffeine consumption. Fast metabolizers BP should return to baseline within a couple of hours. Mine would remain elevated for 10-12 hours.
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Pretty sure there's some age related effects too. Over the last ~20 years I've gone from being happily able to drink coffee after dinner, through not being able to drink it after 5pm or so, and now to having the espresso machine automatically shut off at 2:30pm - otherwise my sleep quality plummets. I'm 57 now, I started noticing poor sleep related to late night coffee in my mid 30s. I do got fairly hard earlier in t…
It's so funny but encouraging to read this. I started drinking coffee in college and could easily finish a whole pot, or have 3 Starbucks venti drip coffees in a day, but I was not sensitive to caffeine at all and could sleep right after. It also didn't seem to have that wake-up alertness effect either Then something changed, and now I am sensitive to it like a normal person. It does wake me up after a sip or two I c…
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Measure your blood pressure. Measure before consumption. Take three different readings. Measure at one hour intervals after caffeine consumption. Fast metabolizers BP should return to baseline within a couple of hours. Mine would remain elevated for 10-12 hours.
Did you measure your baseline blood pressure without caffeine as well?
As a heavy caffeine consumer since at least middle school (I'm 37 currently): consider why you're wanting so much and maybe talk to your doctor about it. Turns out I was dealing with ADHD probably my whole life and caffeine abuse was a cope.
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Thank you for this, I've wanted to do genetic testing for years but don't want it to be stored on anyone's server. Can you explain how it's not stored on any server? Like, you're downloading the .BAM file from Nebula; doesn't that mean they hold onto the data?
Nebula.org does the data sequencing. They support anonymous sequencing. https://nebula.org/anonymous-seq/ Genetic Life Hacks provides the analysis on a number of health and disease related topics. Their analysis is simply allele matching for any given topic (string comparisons). It's all done within the browser. https://www.geneticlifehacks.com/faqs-about-genetics/#:~:tex...
> https://nebula.org/anonymous-seq/
The button to purchase says "coming soon" for me.
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Measure your blood pressure. Measure before consumption. Take three different readings. Measure at one hour intervals after caffeine consumption. Fast metabolizers BP should return to baseline within a couple of hours. Mine would remain elevated for 10-12 hours.
Did you measure your baseline blood pressure without caffeine as well?
Does anyone have personal experience or an understanding of why sometimes coffee in the afternoon actually results in a feeling of perceived tiredness?
My understanding (I don't have any experience in any bioscience, just an avid coffee consumer) is caffeine works because it blocks receptors of adenosine which has a depressive effect and is a signaler that makes you tired. While the caffeine is blocking these receptors, the adenosine is still building up. So once the caffeine starts to wear off all of the adenosine comes rushing in to those receptors and you start to crash. Drinking more caffeine after you have started to feel tired now takes longer for the caffeine molecules to start to muscle in and start filling those receptors again. If you can start to clear out the tiredness receptors ahead of the caffeine hitting them it will make the caffeine more effective. This has led some people to start taking a "coffee nap" where you drink you afternoon coffee, immediately take a short nap to help the caffeine be even more effective when you wake up.
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My problem isn't falling asleep, it's staying asleep. Restlessness at night has become more noticeable as I've gotten older. Cutting down on caffeine, especially later in the day, seems to have helped some. I now have one cup of coffee in the morning, and a cup or two of tea in the early afternoon. This is instead of the two cups in the morning and espresso in the afternoon that I used to have before.
You might try slow release melatonin. I've found melatonin increases the vividness of dreaming, though.
I had a >300mg caffeine/day energy drink habit for a few of years. It took around six months to get past the additional fatigue after quiting. There seems to be some long term effect on me way beyond the half life. Does everyone else get past the effects of going cold turkey in a matter of hours?
I went cold turkey after developing a facial tic and realizing I was consuming 1000 - 1200 mg of caffeine a day (mostly coffee, French press and canned, with some energy drinks too). I was 100% not aware that caffeine is physically addictive and causes receptor changes in your brain. Aside from withdrawal symptoms (joint aches and pains for me), the fatigue didn't fully go away after several months. What did "fix" it…
I’m sure you’ve done the homework but if anybody is reading who hasn’t… if generic short acting ritalin works, great! You know you respond to stimulant adhd meds. Now go find a better long acting one… focalin xr, adderal XR, vyvanse, etc…
To determine whether you're a slow or fast caffeine metabolizer.. Wait for a sale at Nebula.org. Get your whole genome sequenced. ~$200. Having your whole genome sequenced could have added benefits down the road. Download the .BAM file. It will be several gigabytes. Use WSG Extract to generate the 23andMe raw data files. https://www.geneticlifehacks.com/convert-whole-genome-file/ Connect that data file to Genetic Lif…
Look at the variants to see if you have rs762551--that means you're a rapid metabolizer.