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How many medical studies are faked or flawed?

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Re: How many medical studies are faked or flawed?

#91
post #29
post #10

Earlier quoted context omitted.

Yes I work with these IPD spreadsheets every day and they all have typos often in the time/date column (issues with midnight and new years are very common) this can result in an erroneous reporting of something like average drug exposure or clearance if 1 or 2 subjects have uncaught errors in the reported data I would expect 26% or more studies have these flaws but faked data is a different thing entirely and 26% fak…

How many studies are faked and how many just have a 'selective outcome'? Almost every nutritional study I read is at some point sponsored by a group that would benefit from a positive (or negative) outcome. I imagine several studies are run and only the one where the conditions led to a desired outcome are actually published. The researchers may know the results are inconsistent and there is an error somewhere, but i…

That’s why preregistration is important.

Re: How many medical studies are faked or flawed?

#92

The few times I visited a hospital I met people there with complications from previous drugs. One with liver failure. Thanks to that experience no covid shot for me, plus I actually read the pfzier study the judge forced them to release. I now view drug companies on the level of Cartels in Mexico with politicians in their pockets.

> the pfzier study the judge forced them to release

Can you send a link to it?

Re: How many medical studies are faked or flawed?

#93
post #86

Earlier quoted context omitted.

I definitely count on stinging insects that live in holes in my house (or that make holes) to keep other stinging insects away. What I've been told is that opossums are much worse than foxes in the sense that a fox will usually eat a chicken or two to survive but opossums seem to freak out and will kill all the hens in a henhouse in one go. I've often wished I could talk with my cats but more than ever I wish I could…

I have to say that I find foxes beautiful. Then again, I'm not a farmer nor do I keep chickens. I'm a city boy.

The animals we're mostly concerned about at our farm are horses and cats. I don't think there is anything left in North America that can trouble a horse, unless you count mosquito-transmitted infectious diseases. I hear foxes are not dangerous to cats but I believe we've lost some to coyotes.

Mostly we've had people around, either tenants or neighbors, who keep chickens so we don't have to. I'll say the eggs from a small scale chicken operation taste a lot better than commercial eggs.

I definitely thought about trying to draw in the fox but as much as that British lady makes it look easy on Youtube Shorts the legends are that foxes can cause a lot of trouble.

Re: How many medical studies are faked or flawed?

#94
post #90

Earlier quoted context omitted.

Both of those are substances that should be harmful based on the effects of the major ingredients: e.g. caffeine is addictive and when I am deprived of it my schizotypy flares up and I have paranoid episodes (I yell at my wife “why the hell are you always standing where I want to go next?”) I have had two doctors tell me three other reasons why I should quit. Look in the medical literature and it seems outright spamm…

>caffeine is addictive and when I am deprived of it my schizotypy flares up and I have paranoid episodes Dose size matters.

... and I find it very hard to stay at a low dose. If I quit entirely for a few weeks I could probably manage one small coffee a day for a while but inevitably I'd have a rough night and then I need a small and then another small or maybe just a large and pretty soon I can be drinking two whole carafe a day.

I have the same issue w/ cannabis. Right now I have a few plants (legal) in the garden and also a bag that is going to a friend and I don't care. If I had a little puff though the next day I would want another little puff and another and in a week or so I would be like the guy in the Bob Marley song

https://genius.com/The-toyes-smoke-two-joints-lyrics

Re: How many medical studies are faked or flawed?

#95
post #11

Pretty sure most studies about the effects of coffee and red wine are flawed.

What!? Everyone knows a glass of wine once a day is good for your heart, but also even a single glass a year is way too much and causes irreversible damage ;) The old adage applies: "everything nice is either illegal or bad for your health". Or both, I would add.

Everything in moderation, including moderation

Re: How many medical studies are faked or flawed?

#96

"For more than 150 trials, Carlisle got access to anonymized individual participant data (IPD). By studying the IPD spreadsheets, he judged that 44% of these trials contained at least some flawed data: impossible statistics, incorrect calculations or duplicated numbers or figures, for instance. And in 26% of the papers had problems that were so widespread that the trial was impossible to trust, he judged — either bec…

As someone who works in Data Science at FAANG - if you look hard enough - there is something questionably wrong in every step of the data funnel.

And that's when I believe people do have a somewhat best effort to maximize profits. There are plenty of people that only care about career progression and think they can get away with lying and cheating their way to the top. They wouldn't believe that if it didn't work sometimes.

These medical studies are also run mainly to maximize profits, also by some career climbers. They are not run virtuously for the betterment of society.

So I would be astounded if they are as reliable as people might like to believe.

Maybe I'm just being grossly skeptical. Actually, I'd feel better if someone could convince me I'm completely unfounded here.

Re: How many medical studies are faked or flawed?

#97

The few times I visited a hospital I met people there with complications from previous drugs. One with liver failure. Thanks to that experience no covid shot for me, plus I actually read the pfzier study the judge forced them to release. I now view drug companies on the level of Cartels in Mexico with politicians in their pockets.

> the pfzier study the judge forced them to release Can you send a link to it?

Google made it impossible to find, found a link on yandex. https://phmpt.org/wp-content/uploads/2021/11/5.3.6-postmarke...

Re: How many medical studies are faked or flawed?

#98
I'm not as worried about faked/flawed studies as I am about pharmaceutical companies knowingly selling bad drugs to make billions of dollars with no recourse from the FDA. I'll never look at Big Pharma the same way again after watching Painkiller:

https://www.netflix.com/title/81095069

Re: How many medical studies are faked or flawed?

#99

"For more than 150 trials, Carlisle got access to anonymized individual participant data (IPD). By studying the IPD spreadsheets, he judged that 44% of these trials contained at least some flawed data: impossible statistics, incorrect calculations or duplicated numbers or figures, for instance. And in 26% of the papers had problems that were so widespread that the trial was impossible to trust, he judged — either bec…

I think you misread the article slightly. The 26% of zombie papers are inside the 44% of papers that contained at least some flawed data. Look at the figure just below this quote where the blue bar, indicating papers he thought were ok, covers more than 50%.

Which, ironically, just shows how easy it is to make mistakes not just in complicated statistical methods, but in basic interpretation of what numbers mean in the first place.

Re: How many medical studies are faked or flawed?

#100

"For more than 150 trials, Carlisle got access to anonymized individual participant data (IPD). By studying the IPD spreadsheets, he judged that 44% of these trials contained at least some flawed data: impossible statistics, incorrect calculations or duplicated numbers or figures, for instance. And in 26% of the papers had problems that were so widespread that the trial was impossible to trust, he judged — either bec…

"So, 70% fake/flawed." I think you miss read that section? Only were 44% fake or flawed acording to this study. The 26% that were very flawed is a subset of the 44% that were flawed in general. So those precentages should not be added together.

Oh the irony!
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