Psychedelic brew ayahuasca’s profound impact revealed in brain scans

> 1. The results of this study are about long-term treatment, not a single dose.

DMT acts on the HTR2A and HTR2C receptors. When you activate HTR2C receptors at high levels the nerves respond by changing the number HTR2C receptors. This is called having an "effect of receptor density".

You can read about it in this study: (I know what you are going to say, that this proves one cannot get habituated to DMT But that is wrong adn you will need to read the second study to understand why.

https://www.sciencedirect.com/science/article/abs/pii/S00913...

Because drug efficacy changes with receptor density and cellular microenvironment, we also examined the properties of DMT in native preparations using a behavioral and biochemical approach."

One difference was evident in that the 5-HT2C, but not the 5-HT2A, receptor showed a profound desensitization to DMT over time. This difference is interesting in light of the recent report that the hallucinogenic activity of DMT does not tolerate in humans and suggests the 5-HT2C receptor plays a less prominent role in the action of DMT.

https://www.cureus.com/articles/62522-5-ht1a-and-5-ht2a-sign...

Furthermore, abnormal receptor density ratios are strongly associated with positive and negative symptom severity, which are typically assessed using the Scale for the Assessment of Negative Symptoms

In addition, Hurlemann et al. (2007) proposed that 5-HT2A receptor density was also decreased in the At-Risk Mental State patient subgroup, regardless of conversion to psychosis [4]. The progressive decline in subcortical 5-HT2A receptor density could provide an indicator of conversion to schizophrenia.

> That is your interpretation (with no evidence.)

That is what is called a hypothesis. Do you ever have an original insight or do you just walk around nixing creative thought because no one ever thought of it before?

I mean you focus only on the study and you cannot see the connection because you so myopic.

> Well that's impressive. May I ask what your h-index is?

It is people like you who keep science in the dark ages.

I cured my schizo-affective Bipolar disorder without medication. What have you done?

> I think it's the other way around, where synthetic hallucinogens can be fully purified and measured

My point was, with synthetics it's still caveat emptor. Natural products have that too - a measure of uncertainty - but without a possible profit motive and without intent to conceal possible incompetence. Woodstock + brown acid.

I see in another comment you said you cured your schizo-affective Bipolar disorder without medication. Do you mind if I ask how you did that? I have a condition (probable personality disorder with extreme anxiety) and I've been taking methadone to get off of opioids for about 4 years now, and I noticed that when I go down on my dose, my symptoms start to flare up. So in essence I'm keeping it in check with the same class of drugs I was using to self-medicate with. I have done DMT and it did do wonders for me (went from daily suicidal ideation to almost no suicidal thoughts in almost a decade) but I think there has to be more.