91–100 of 228 posts
The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.
> ... to simply stop consuming nutrients for extended periods of time That is not simple for most people.
Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive e…
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What's NMN?
Nicotinamide Mononucleotide, an unregulated supplement. Note also: > We found that, when data from all organisms studied were combined for each compound, aspirin resulted in the highest percent increase in average lifespan (52.01%), followed by minocycline (27.30%), N-acetyl cysteine (17.93%), nordihydroguaiaretic acid (17.65%) and rapamycin (15.66%), in average. [0] Though I'd consider whether flies and worms are go…
The idea that you could just take a pill one time and be "protected from aging" or something sounds ludicrous. Would be interested to see people reproduce these results and have them supposedly transfer over to humans. Humans are a much longer time scale. I always go back to the SENS concept of having several different problems to solve related to built up damage, cells that won't die, etc.
Now we have vaccines that eliminate a specific form of cancer.
Perhaps we will find a way to pack all the different treatments for the various SENS forms of aging into a single one-time pill.
Maybe it will just be self-replicating nanobots.
What a fascinating time we live in where we can actually start to make educated guesses about the viability and timeframe for these kinds of things.
Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive e…
Do you have a personal comment on the long and scary list of side effects it causes?
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As long as you can bear it. Which for me has been 24 +/- 4 hours between meals for 9 months and counting.
> long as you can bear it This gives zero evidence a threshold has been reached for enzyme activation. There is evidence of effects after 72 hours of fasting [1]. But we also know of counter-effects around 24 hours, when glucose released by the liver breaking down amino acids from muscle wasting (EDIT: autophagy) partially reactivates mTOR [2]. It could be massive or minimal benefits through 24 hours, we don't know,…
Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic. Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.
Human bodies are crazy cool. 1. There is some internal clock that we don’t yet understand but clearly exists. Specifically your digestive track proactively activates itself in preparation for food. Then if food doesn’t come, your stomach will “growl”. It takes a 1-3 months for your clock to readjust such that it doesn’t do that. After this you will not “feel hungry”. If you intermittently fast for a year or so, you w…
What's the latest on bloodboys? That is : periodic blood transfusion from healthy young vegan donor. It works very well. Rejuvenates ancient billionaires. Surely it's superpopular among the oligarchs. Probably not the kind of thing you want in the news (vampires!). The technical term is Parabiosis . These guys offer the service : https://www.ambrosiaplasma.com/
Every day we stray further from god's light
[2] - French Church abuse: 216,000 children were victims of clergy - inquiry
1. https://www.justiceinfo.net/en/45133-sexual-abuse-church-map...
genuine question: why would someone want to live longer than the average? Edit: I ask because I personally don't see a reason to stay alive while people I love are dying, I don't see a reason to stay alive in an already fucked up planet, while we empty all the resources, etc. But you guys are so smart, intelligent and clever, why even bother.
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> ... to simply stop consuming nutrients for extended periods of time That is not simple for most people.
This is Hackernews. The cure is fasting. Whatever disease you have, the cure is fasting.