61–70 of 228 posts
Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic. Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.
I have been taking rapamycin for many years now. It's obviously not ready for anywhere near the general public and is never something I'd suggest to someone at this point, but my own results have been wonderful and my blood panels and energy levels are great. If I had to guess, when properly used, this would probably add a full 5-10 years onto the lifespan of a lot of people. When combined with many other promising t…
I'm currently taking 2mg once a week on my rest day; I started with 1mg and after 1 month added another MG. I'll continue each month until I reach 8MG once a week, which is the dosage the doc I worked with in Texas to get my prescription recommended and most people seem to take.
Also - I would say that NMN + Rapa is a completely life altering combination for anyone 50+. I feel like I can lift harder and longer now than when I was in my 40's and things seem to be getting easier the farther into my rapa routine I get.
Also also - you can find rapamycin online / overseas under its other name - Sirolimus - and the cost is a little lower than getting a proper US prescription.
The idea that you could just take a pill one time and be "protected from aging" or something sounds ludicrous. Would be interested to see people reproduce these results and have them supposedly transfer over to humans. Humans are a much longer time scale. I always go back to the SENS concept of having several different problems to solve related to built up damage, cells that won't die, etc.
The basic hypothesis is that cells operate in two modes, one storing up stuff in times of plenty, and a second mode which uses up the stores and cleans up, active during lean times. mTor is supposed to be the chemical signal which indicates which mode to act in; it's inhibited by both fasting and rapomycin.
Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic. Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.
The hardest moment is right when your body is about to switch from using glucose to using ketone bodies for energy. After that the hunger, feeling anxious, etc stops.
The time it takes to get to that point (when feeling "bad" intensifies) and how long the transition takes can be influenced.
Primarily, by what you eat before you fast. In general, avoid eating carbohydrates, especially simple carbohydrates like sugar, fruits, past, bread, etc. I usually eat more protein and fat before fasting.
Another "trick" during fasting is to cheat your stomach a bit by filling it with liquids - I drink lots of water and tea.
The main thing to remember - it will pass, and you will feel great after your body switches. Your mind will tell you that it will just progressively get worse the deeper you get into the fast - it's not true :)
Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic. Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.
1. There is some internal clock that we don’t yet understand but clearly exists. Specifically your digestive track proactively activates itself in preparation for food. Then if food doesn’t come, your stomach will “growl”. It takes a 1-3 months for your clock to readjust such that it doesn’t do that. After this you will not “feel hungry”. If you intermittently fast for a year or so, you will likely never again “feel hungry”.
2. Eating meals is a habit. Arguably more addictive than smoking. But like with any habit, it can be broken. This isn’t the feeling of hunger… rather a weird compulsion. If you stop fasting for a few months, this will need to be rebroken every time. I’m currently struggling to re-break it.
3. The social pressure to eat is real! This is the hardest to contend with.
Good luck :)
https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-...
The drug has been known for a long time but human trials always seems elusive
The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.
I'm a month into taking rapa and already I feel like it's having a noticeable effect. I'm curious what others on this threads dosage looks like. If you prefer to keep it private, you can email me directly (my email is on my profile). I'm currently taking 2mg once a week on my rest day; I started with 1mg and after 1 month added another MG. I'll continue each month until I reach 8MG once a week, which is the dosage th…