Brain imaging before and after Covid-19 in UK Biobank • Hacker News Board

Re: Brain imaging before and after Covid-19 in UK Biobank

#91

Post by brigandish » Sun, Jun 20, 2021, 4:08 PM UTC

causality0 wrote: post #58

ganzuul wrote: post #29

Earlier quoted context omitted.

How old are you? Were you completely healthy before?

30. Overweight but no actual medical problems. Not prescribed any medications. Not a drug, cigarette, or alcohol user.

I don't mean be invidious, but being overweight is an actual medical problem, one that's been strongly linked[1][2][3] with susceptibility and severity of the disease.

I can't recommend reading the World Obesity Atlas pdf enough as it provides possible explanations for the disparities in cases and deaths we've seen in different societies.

[1] https://www.worldobesity.org/resources/resource-library/covi...

[2] https://www.gov.uk/government/publications/excess-weight-and...

[3] https://pubmed.ncbi.nlm.nih.gov/32788355/

Re: Brain imaging before and after Covid-19 in UK Biobank

#92

Post by drclau » Sun, Jun 20, 2021, 4:11 PM UTC

causality0 wrote: post #87

torben-friis wrote: post #78

Earlier quoted context omitted.

Don't lose hope. I got in October, similar effects, and I've been recovering a lot of my smell and taste, veery slowly and in "bursts". Nowadays I'm almost fully ok, the only smells I haven't recovered are body odor (which I can smell, it's just really different) and feces and trash, which for some reason smell in a very particular sweet way, kinda like rotten meat. That last one, for some reason, seems to be really…

Yeah, the first time I recovered my smell feces took the longest to come back. Since I already recovered and didn't catch covid again, I can't help but think my current problem arises from some kind of incorrect healing. Like a nerve pathway is connecting to the wrong thing somehow.

This is probably the first time I read about these side effects. Are you certain it's your perception that has changed (ie. neurological changes), as opposed to the actual smell? I would not be surprised at all if Covid has an impact on the gut flora.

Re: Brain imaging before and after Covid-19 in UK Biobank

#93

Post by mrfusion » Sun, Jun 20, 2021, 4:13 PM UTC

JohnJamesRambo wrote: post #4

I wish I could get people that are avoiding the COVID vaccine “because we don’t know what the long term effects are” to realize that we have real data showing that there are long term effects from getting full blown COVID. You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body? The whole genome and all the proteins made?

If you find yourself saying or thinking "It's so simple why don't people understand" with regard to a political or social issue, there's a good chance you don't fully understand the issue.

Re: Brain imaging before and after Covid-19 in UK Biobank

#94

Post by justapassenger » Sun, Jun 20, 2021, 4:13 PM UTC

dukeofdoom wrote: post #83

ch4s3 wrote: post #67

Earlier quoted context omitted.

> until more is known about long term effects I'm curious about this line of reasoning. We've been testing mRNA treatments for other diseases for about 25 years now. The approach was abandoned for gene therapy because the effects weren't long lasting. We have follow up data on people who participated in those studies, and to my knowledge there aren't any documented negative long term effects. We know what the vaccine…

Not caution. Willingness to accept death should it come. I'm part of the natural world, and viruses are a natural way that keep population in balance. All these vaccines are keeping more kindling for a bigger fire down humanity's timeline. I would probably reconsider if the odds where much worse than 1%.

If you truly believe that viruses are here to keep our population in balance and we should be part of natural world, why would higher chances of dying affect your decision? Following your logic it just means that nature have much stronger reasons to decimate humanity. Shouldn’t you accept it?

Re: Brain imaging before and after Covid-19 in UK Biobank

#95

Post by brigandish » Sun, Jun 20, 2021, 4:13 PM UTC

b0sk wrote: post #68

dukeofdoom wrote: post #52

Earlier quoted context omitted.

As someone not getting the vaccine. I'll explain my reasoning. At this point, the odds of getting COVID are small. And much better treatments are around the corner. Thus a 1% mortality rate for the elderly, with multiple co-morbidities, will be even lower for someone my age should I get it at some point. Vaccines introduce a foreign substance 100% of the time into your body, sometimes have side effects. I won't even…

> At this point, the odds of getting COVID are small. That's because the herd around you has been vaccinated. So you are OK with others getting vaccinated for your benefit but wouldn't do your part to benefit the herd. Awesome! Maybe your post is parody. Can't really tell.

> So you are OK with others getting vaccinated for your benefit but wouldn't do your part to benefit the herd.

Shouldn't they be okay with getting vaccinated? They did it for their own reasons, and that's a good thing, but they're not martyrs or saints.

Re: Brain imaging before and after Covid-19 in UK Biobank

#96

Post by ekianjo » Sun, Jun 20, 2021, 4:13 PM UTC

vajrabum wrote: post #55

ekianjo wrote: post #43

Earlier quoted context omitted.

> You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body? Rather than injecting yourself with mRNA which will create long-term antibodies in your organism which will be reactivated any time something like COVID19 appears again in the nature, it's probably safer to rely on COVID19 treatments are are short lived (as in, metabolized) and reduce the viral load swiftly.

What other viral diseases are easily treatable by medication as opposed to vaccination? Are there any?

HIV is effectively treated by tri-therapies.

Re: Brain imaging before and after Covid-19 in UK Biobank

#97

Post by colordrops » Sun, Jun 20, 2021, 4:14 PM UTC

drclau wrote: post #92

causality0 wrote: post #87

Earlier quoted context omitted.

Yeah, the first time I recovered my smell feces took the longest to come back. Since I already recovered and didn't catch covid again, I can't help but think my current problem arises from some kind of incorrect healing. Like a nerve pathway is connecting to the wrong thing somehow.

This is probably the first time I read about these side effects. Are you certain it's your perception that has changed (ie. neurological changes), as opposed to the actual smell? I would not be surprised at all if Covid has an impact on the gut flora.

According to a Harvard article I read, it's caused by damage to the sensors in the nose, rather than brain damage. I have the problem myself and it's definitely not changes to the smells themselves.

Re: Brain imaging before and after Covid-19 in UK Biobank

#98

Post by loteck » Sun, Jun 20, 2021, 4:15 PM UTC

r3trohack3r wrote: post #46

hallway_monitor wrote: post #6

Earlier quoted context omitted.

Agree completely. That said, ideally I don't want either. Since a lot of people wanted to get vaccinated immediately, I can avoid that and the virus with very high probability. If needed, I'll take v3 or so of the mRNA vaccine.

I’m not sure which child to respond to, so responding here. I’m pretty well aligned with this and I’m not sure why it’s getting the downvotes. COVID has never been communicated to me as something serious for my age group. Maybe I’m misinformed, but I’ve never feared getting COVID. I was _terrified_ of needing hospital care _during a hockey stick_. COVID was communicated to me as a hospital killer. I was terrified I’d…

Being a part of a chain of transmission that kills someone, when you could have instead been the person who broke the chain and saved a life?

Re: Brain imaging before and after Covid-19 in UK Biobank

#99

Post by dukeofdoom » Sun, Jun 20, 2021, 4:15 PM UTC

gspr wrote: post #76

dukeofdoom wrote: post #52

Earlier quoted context omitted.

As someone not getting the vaccine. I'll explain my reasoning. At this point, the odds of getting COVID are small. And much better treatments are around the corner. Thus a 1% mortality rate for the elderly, with multiple co-morbidities, will be even lower for someone my age should I get it at some point. Vaccines introduce a foreign substance 100% of the time into your body, sometimes have side effects. I won't even…

Kindly go to hell (or go live alone in the woods somewhere), you egoistical bastard.

The most vulnerable are in two groups.

1) Obese and 2) the elderly with multiple co-morbidities.

Group 1, is more morally culpable for their own gluttony then I am for not getting the vaccine. Society paid a high price to keep them around.

Group 2, reducing chance of dying from one disease only increases the odds of dying from something else. Very likely that these people would have died from their other diseases and co-morbidities.

Re: Brain imaging before and after Covid-19 in UK Biobank

#100

Post by onlyrealcuzzo » Sun, Jun 20, 2021, 4:16 PM UTC

goodoldneon wrote: post #13

wombatmobile wrote: post #2

This sounds alarming: > There is strong evidence for brain-related pathologies in COVID-19, some of which could be a consequence of viral neurotropism. This doesn't: > We further compared COVID-19 patients who had been hospitalised (n=15) with those who had not (n=379), and while results were not significant, we found comparatively similar findings to the COVID-19 vs control group comparison What are the quantitative…

Kind of a tangent, but I get frustrated when researchers publicly release results when one of their groups have a ridiculously small sample size. It’s irresponsible to release results based on 15 people

I thought this also - but as it turns out - you can make conclusions with really small sample sizes in medicine.

For example (this has nothing to do with the paper), if the average rate of some condition - some rare brain tumor - is 1 in 50M - and you take 200 COVID-19 patients and 4 of them have it - and they have several of these tumors - you can have high CI & Power with a low sample size.

When you're doing conversion rate optimization - it's usually just "did this person make a purchase?" And usually, your base rate is not less than 1/1000... But in medicine, there are ways to measure the severity of the symptoms and a lot of things are quite rare.