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Chloroquine has shown apparent efficacy in treatment of Covid-19

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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#91

Post by MarcScott »

JamesBarney wrote: post #73
spitfire wrote: post #68

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

From wikipedia > In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm[3] (83 mg per liter if calculated by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg,[4] and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult).[5] It is often recommended as a relief for leg cramps, but medica…

Clarissa Dickson Wright suffered from organ damage caused by too much quinine, from the copious G&T she drank.

https://www.telegraph.co.uk/foodanddrink/foodanddrinknews/10...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#92

Post by toomanybeersies »

inferiorhuman wrote: post #10
toomanybeersies wrote: post #7

Earlier quoted context omitted.

GPs won't prescribe on the basis that you might get sick and require a particular medication. You can't walk into your GP's office and ask for antibiotics, for instance.

That's pretty much the exact set of circumstances that chloroquine is usually prescribed under.

My mistake, I didn't realise chloroquine was a malaria prophylactic (I've always been given other anti-malarials), I thought it was only a treatment for when you were actually diagnosed with malaria.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#95

Post by ailideex »

nikkwong wrote: post #94

Why haven't the markets reacted positively to this news?

You know, I read this, and then I read other things implying we will fix climate change from this crisis, and I wonder ...

The markets has not reacted positively to this news because something possibly helping makes no difference. Actually making a difference to the situation makes a difference. Until the point where there clearly is something that makes a difference the outlook is really bleak.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#96

Post by jamesblonde »

simpsond wrote: post #13

I just recently watched an interesting video about COVID-19, Zinc and Clororquine. It explains some of the fundamentals: https://www.youtube.com/watch?v=U7F1cnWup9M

This is a good video describing the hypothesized method of action of Chloroquine. Chloroquine opens up receptors on the cell membrane to allow Zinc to enter cells - Zinc interfers with the replication of sars-cov-2. So, take Zinc supplements to increase general Zinc levels in plasma/tissue and let in Zinc with Chloroquine.

An alternative proposed method of action for Chloroquine is that it binds to proteins created by sars-cov-2 (ORF3a, ORF10, ORF8). Those ORF proteins bind to heme (red in red blood cells), preventing oxygen from being transported - https://twitter.com/davidasinclair/status/123897208275664896... David Sinclair based his tweets on this paper:

https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf...

But most organizations are going with the Zinc theory of Chloroquine. So take Chloroquine with Zinc supplements (France, South Korea, China are doing clinical trials). Here is a translation of a Chinese study intermediate results - no data was released, which makes some people sceptical:

https://twitter.com/jim_dowling/status/1239255793171660800

Here is a great summary of available treatments used in different countries

https://epidemio.wiv-isp.be/ID/Documents/Covid19/COVID-19_In...

Although untested in-vivo, many clinicians prefer hydroxycholorquine due to its superior safety profile - and 4X better efficacy in-vivo (not in humans, in cells). I tried ordering that last week when the paper came out, not sure if i will get it, though.

Chloroquine is kind of old news. There has been a lot of talk around Chloroquine, starting around 6 weeks or so ago - the UK banned export of it nearly 4 weeks ago https://www.pharmaceutical-technology.com/comment/parallel-e.... I managed to order some before that.

References:

"Chloroquine Is a Zinc Ionophore" https://journals.plos.org/plosone/article?id=10.1371/journal...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#97

Post by aksss »

ggm wrote: post #66
ggm wrote: post #44

This is an increadibly potent drug with serious side effects according to anything I read, its not first-line treatment its last-line, when everything else fails. You can go blind, irreversibly. Please people, speak to trained medical people before reaching to the drug cabinet. I am not a doctor. This advice is not meant to contradict the rule of only taking medical advice from medical professionals.

To the plus side, its cheap. So, absent drug companies motivations to make cheap drugs (low) it is affordable at scale, and if it turned out to be useful e.g. early in the stage of the disease, this might be very good for wild infections. Or, maybe it points to drugs which are safer, equally cheap, and able to be made with less side effects. (see rule one: this is not medical advice)

Cheapish - as I recall about $300 for 90-day supply of generic hydroxychloroquine if paying cash in US. I mean, not cancer drug spends but if you are on it for life it’s an annoying annual expense.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#98

Post by onion2k »

JamesBarney wrote: post #73
spitfire wrote: post #68

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

From wikipedia > In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm[3] (83 mg per liter if calculated by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg,[4] and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult).[5] It is often recommended as a relief for leg cramps, but medica…

about about 200 gin and tonics per day

Great news. I'll only have to cut down a little.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#100

Post by dmix »

spitfire wrote: post #68

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

> each day along with a zinc pill.

The scientific studies being cited for these COVID-19 vaccines using Chloroquine specifically state zinc supplements by themselves are not ionized and are therefore useless for fighting the virus. Even though zinc entering cells is a key part of how it works, zinc can't enter the cells in question unless it's properly ionized, which is why they use Chloroquine... an ionized zinc delivery system... jumping to "lets all take some Zinc pills with gin & tonic" is irresponsible advice IMO.

These sorts of Naturopathy proposals is exactly how we got COVID-19 in the first place (ie, people eating Pangolins in east asia for Chinese medicine purposes - the most trafficked animal in the world - which just happens to be infected with a coronavirus that matches 99%+ to the one currently making the rounds).

This sort of weak adherence to a scientific approach to medicine + some vague historical reasoning is the problem, not the solution.

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