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Progress of anti-aging therapies by clinical trial stage

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Re: Progress of anti-aging therapies by clinical trial stage

#91

Post by pstuart »

LinuxBender wrote: post #27
DennisP wrote: post #21

Earlier quoted context omitted.

I could really use that weird side effect. What other molecules did you cycle up/down?

I owe HN community a blog update on this process and I promise I will do that in the coming couple weeks. I've been a bit busy as of late. When I do, I will add it to my profile. It's not quite as simple as what to take, but also when to take, in what combinations and why. And it probably isn't the most scientific process, so I'm sure I will catch some flak for it.

It might be worth posting to reddit.com/r/longevity as well. I'm looking forward to it.

Re: Progress of anti-aging therapies by clinical trial stage

#92

Post by valgor »

brooklyndude wrote: post #35

You will get old. You will die. Just face reality. This trying to always put off aging is hopeless. Utterly futile. Enjoy every day, don't waste a second. You will die. And you ain't ready for it. But Mother nature is.

The common cold use to kill us. Science helped a lot of people overcome the common cold. One day we will look at aging like the common cold.

Re: Progress of anti-aging therapies by clinical trial stage

#93

Post by chrisco255 »

jonplackett wrote: post #90
Erlich_Bachman wrote: post #54

Earlier quoted context omitted.

> I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. If you have any ready-researched and outlined sources or links for this, please post them here for reference. I know that we all can google, but I think linking here will help a lot of people, me included. HN articles are sometimes used as an online notepad of sorts, a repository of well researched and comp…

Is HGH + DHEA available to buy like a supplement? I would have presumed something containing hormones would be more regulated?

Not in the U.S.

Re: Progress of anti-aging therapies by clinical trial stage

#94

Post by JimboOmega »

jonplackett wrote: post #90
Erlich_Bachman wrote: post #54

Earlier quoted context omitted.

> I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. If you have any ready-researched and outlined sources or links for this, please post them here for reference. I know that we all can google, but I think linking here will help a lot of people, me included. HN articles are sometimes used as an online notepad of sorts, a repository of well researched and comp…

Is HGH + DHEA available to buy like a supplement? I would have presumed something containing hormones would be more regulated?

Not only is HGH regulated, it even is specifically addressed under law (in the US) that lead some to believe that even prescribing it off-label it is illegal. See:

https://en.wikipedia.org/wiki/HGH_controversies#Law

Re: Progress of anti-aging therapies by clinical trial stage

#95

Post by JimboOmega »

xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

What's the difference between NMN vs NR? I take NR and they're chemically similar and I thought both are sold as anti-aging?

Re: Progress of anti-aging therapies by clinical trial stage

#96

Post by xiphias2 »

jonplackett wrote: post #90
Erlich_Bachman wrote: post #54

Earlier quoted context omitted.

> I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. If you have any ready-researched and outlined sources or links for this, please post them here for reference. I know that we all can google, but I think linking here will help a lot of people, me included. HN articles are sometimes used as an online notepad of sorts, a repository of well researched and comp…

Is HGH + DHEA available to buy like a supplement? I would have presumed something containing hormones would be more regulated?

No, as it requires strong medical supervision. Greg Fahy’s company is running experiments on humans approved by the FDA in his company in Los Angeles.

Re: Progress of anti-aging therapies by clinical trial stage

#97

Post by bufferoverflow »

lcnmrn wrote: post #87
ganeshkrishnan wrote: post #84

Earlier quoted context omitted.

Ai is hardly hyper inflated. Everything from your phone to cars to planes use ai and machine learning one way or the other.

But it's not actually AI, it's just programmable probability.

So is your brain. But it's not even yet programmable.

Re: Progress of anti-aging therapies by clinical trial stage

#98

Post by xiphias2 »

asdff wrote: post #73
xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

chances are you had your dna genotyped, not sequenced, if it was cheap. measuring your methylation patterns is not going to be cheap as you need to sequence your dna twice to see what has actually been methylated. i'm not sure if any companies are offering a consumer targeted panel approach. https://en.wikipedia.org/wiki/Bisulfite_sequencing

I’m planning to do 450k or EPIC BEADS chip, not whole epigenom sequencing, as most researchers used 450k chip for finding the interesting methylation differences for people affected by high air pollution. I saw about $500/sample, but if it’s significantly more, it’s not a problem for me, my chronic disease isn’t going away anyways.

Re: Progress of anti-aging therapies by clinical trial stage

#99

Post by godshatter »

throwaway_tech wrote: post #46
lawrenceyan wrote: post #20

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

>Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training Yes, but the problem is this is such a broad brush stroke. For example, most people who are chronically stressed will generally never be able to obtain relief. There is a common joke about abs being made in the kitchen not in the wei…

>As to intermittent fasting, that has become a major fad since the Nobel Prize for Autophagy (with the most popular implementation being a 8/16 time restricted eating "fast"). In other words the goal is to trigger the body to begin consuming/recycling dead cells and other cellular waste; however, this typically isn't triggered by time restricted eating, but requires longer periods of fasting (usually kicking in around after 20-24 hours of fasting).

There's always OMAD (one meal a day). I generally fast 23 hours out of every 24. I rarely think about my next meal until I get home from work and it's time to cook something.

Re: Progress of anti-aging therapies by clinical trial stage

#100

Post by xiphias2 »

waserwill wrote: post #69
xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

Maybe you know this, but: Interpreting DNA methylation isn't straightforward. Since it's involved in gene regulation and cell differentiation, it's variable across cells. Due to regulatory networks, whether any particular methylated region is responsible for some outcome may also be unclear. That being said, if you have reason to believe that the knowledge will help, or are just curious, feel free

sure, I understand that, but from what I saw the data isn’t that hard to process either, there are multiple R libraries actually that help, I’m currently also learning Genomics Analysis Harvard course at edx.org.

I already found multiple papers published in the last few years that identified the important locations with methylation changes, and those targets map to known illneses.

I tried to go to many doctors, but as they couldn’t measure any important changes with their toolboxes, they all sent me to psychologists.

Thanks for offering help, I’m always interested in learning more about genomics, though right now my plan is to learn by reproducing some articles that I read that contain methylation data sets (after the Harvard course).

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