Live data from Hacker News

Infectious Theory of Alzheimer's Disease Draws Fresh Interest

npr.org

91–96 of 96 posts

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#91
post #37

Earlier quoted context omitted.

I have worked in many as a care aid providin direct care to residents. I worked for 7 years in one facility that worked with advanced Alzheimer's and dementia like condition clients. I would not describe the nursing home as cruel or in-human, though to a person with sound mind it certainly would. The people who resided there simply could not live alone. They would soon be seriously hurt or die. So yes when they enter…

There are indeed excellent facilities for elder care. But there are many horrific ones, and the difference between them can be hard for outsiders to determine (whether for families, or for yourself). Case in point: My parents had one hell of a time finding good care for my grandfolk (incl. siblings of grandparents). In their state, there is an entire industry of corrupt nursing homes, which also have all sorts of "aw…

> staff physicians who never, ever appear on site, yet who collects a paycheck by prescribing tranquilizing drugs for any resident at the facility's request, all sight unseen

My mother and her siblings have had EXACTLY this experience with my grandfather – and they've had prior experience choosing nursing homes. It's horrible. They dope him up on who knows what medications for perceived illnesses without consulting family. Thank goodness my attentive and no-bullshit aunt discovered they were medicating him for "pneumonia" and "congestive heart failure" prescribed by a call-in quack for what turned out to be a bit of aspirated fluid. She forced them to get him off the meds and he returned to normal (modulo Alzheimer's) in days.

The whole industry is based around appearing like they're doing something to oblivious or disinterested families (which unfortunately exist), while doping their helpless patients into a slow meaningless death. There are good individuals (my folks made sure to make ties with them, else my grandfather would quite literally have died due to negligence by now), but the industry as a whole is rotten.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#92
post #37

Earlier quoted context omitted.

Nursing homes are among the cruelest and most in humane institutions, worse than prison in many ways. Anything that avoids nursing home days is worth it’s weight in gold.

I have worked in many as a care aid providin direct care to residents. I worked for 7 years in one facility that worked with advanced Alzheimer's and dementia like condition clients. I would not describe the nursing home as cruel or in-human, though to a person with sound mind it certainly would. The people who resided there simply could not live alone. They would soon be seriously hurt or die. So yes when they enter…

Can you provide referrals and / or known good facilities? Direct email welcome.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#93
Crohn's is another inflammatory disease that has long been suspected by some researchers to be infectious. The company RedHill Biopharma just showed that a combination of generic antibiotics could be as effective as Humira, the highest gross-selling drug in the world, at treating the condition.

https://www.redhillbio.com/RedHill/Templates/showpage.asp?DB...

I keep seeing news about severe impacts of chronic infections that we aren't good at testing for, and aren't good at treating. Gut microbes that cause cancer, only just recently deciding that HPV's cancer risk to men was significant, and chronic Lyme disease are some examples.

This article cites the historic example of peptic ulcers, which the medical community didn't believe were caused by an infection, until after Barry Marshall infected himself with H. pylori in 1984, developed disease, and treated himself for it with antibiotics. Marshall and his partner won a Nobel Prize for this work.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#94
post #90

Earlier quoted context omitted.

This would make sense. HerpesVirus has been shown to cause atherosclerosis as well, in humans. The connection? Herpes binds to the APOE gene sitting on cholesterol-carrying LDL particles .... https://medium.com/@InfinoMe/cholesterol-have-we-shot-the-me... I spent 3 years in one of the nations top alzheimers centers. It is still shocking to me how some of the seasoned veteran professors in the field are both unfamilia…

So what's up with tangentially related associations like Parkinsons, Lewy Body dementia (see: Robin Williams) and also Chicken Pox and Shingles. Aren't these all a relatable set of problems, then?

I personally think so, yes. Evidence in the literature is more scant, but there are documented cases.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0404....

The more I think about the anatomy of cranial nerves, the more I wonder if different dementia subtypes are caused by different viral strains that have gotten really great at infecting specific nerves. Take for example the trigeminal nerve. There is literature out there showing that a large fraction of people (>70%) have HSV-1 present there at time of death : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546524/

How would the virus get in? Im wondering if its via the nerves in your teeth! http://teachmeanatomy.info/head/cranial-nerves/trigeminal-ne...

For dementia .... still working on that.... Im convinced though now that frontotemporal dementia might have something to do with the facial nerve getting infected somehow. It would make sense, given the facial paralysis present in bvFTD patients. Can't find it now, but theres a paper out there connecting coxsackievirus to FTD

EDIT: BTW, for shingles, connection is much stronger with Alzheimers

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699837/

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#95

Earlier quoted context omitted.

Thank you.

Curry is anti-inflammatory. There are studies on how the Mediterranean diet helps protect against brain inflammation. They are usually about depression, not Alzheimer's, and they typically claim that consumption of olive oil and fresh fruits and veggies are big factors. Those might provide clues for you to start your search. When my dad had Alzheimer's, I think they also gave him a children's aspirin (or possibly som…

Thank you, appreciate that a lot! My mom already eats pretty healthy and exercises regularly, but I'll try to point her to specific foods. I am somewhat surprised with all the research about that there's no prescription drugs or similar items that may be beneficial.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#96

Earlier quoted context omitted.

Curry is anti-inflammatory. There are studies on how the Mediterranean diet helps protect against brain inflammation. They are usually about depression, not Alzheimer's, and they typically claim that consumption of olive oil and fresh fruits and veggies are big factors. Those might provide clues for you to start your search. When my dad had Alzheimer's, I think they also gave him a children's aspirin (or possibly som…

Thank you, appreciate that a lot! My mom already eats pretty healthy and exercises regularly, but I'll try to point her to specific foods. I am somewhat surprised with all the research about that there's no prescription drugs or similar items that may be beneficial.

"Life is chemistry"

"Let your food be your medicine"

I started with anti-inflammatory medication for my condition and inferred that an anti-inflammatory diet might help me get off the drugs. It did.

I think an anti-inflammatory diet is a superior solution

Best.

Post reply on HN