Interning at Boeing in 2005, when the Dreamliner was still 2-3 years away from production, I asked a BD manager if Boeing was worried about A380 (the burning question at the time was "Who is going to win, A380/Airbus or Dreamliner/Boeing"). Without pause, he said "Not worried at all, A380 serves the hub and spoke model, which is dying. People hate layovers, they want more direct flights." Not a hard insight to grasp,…
As long as hub & spoke works out cheaper (which it will thanks to centralisation & economies of scale) it'll have a place in the budget market
The a380 was made for large traffic to and from Asian cities. If there is going to be a savior for the program, that's where it will come from.
There are rumors that Airbus has approached China to talk about taking over a large portion of the project, in exchange for Chinese orders. That's something to keep a eye on.