801–810 of 1001 posts
>...combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the WL and cardiometabolic benefits of GLP-1 RA.
I count 18 or so here...
I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…
My view about obesity has shifted dramatically since Ozempic came out. Before this, I didn't think about it too much (I am not obese myself). I notice now that there is a LOT of judgement, bias(?), around obesity, that people, obese or not, carry with them [1]. I certainly carried that bias, and the reason I noticed it was because Ozempic is literally an external substance that you take that simply makes obesity go a…
I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…
I'm with you on this, tirzepatide has been life changing for me. I've struggled with my weight my whole life and I can actually imagine a future where I lose enough that I'm no longer ashamed of my weight. I've been on tirzepatide for just over a year now. Before that, I managed to lose 6% of my body weight over the previous year. With tirzepatide, I've lost an additional 17% of my body weight, for a total of 23% ove…
Forgive my ignorance and curiosity, was the feeling of hunger due to drastic reduction in portion size? Could you not eat some low-calories filling food?
I ask cause I've been overweight and sometimes obese most of my adult life, but when on a diet I usually feel "unsatisfied" but rarely actually hungry, e.g. I can eat a couple carrots or whatever and hunger goes away, but I would still crave a hamburger.
Still, I'm happy for you that you found something that works!
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Sounds like a miracle drug that helps with all afflictions that come with our modern life/sedentary living.
The problem with this (and all diet plans/drugs) is the lifestyle that led to problem in the first place. If you do not change your lifestyle, for real and not just superficially, then you will relapse with a vengeance. That is to say, be careful with using a drug as a crutch. Sure, it can artificially make you much more interested in not consuming so many calories and/or perhaps being more active than before - but y…
Would we consider insulin a crutch? Think of this as something in the same league. At least that is the case for a good chunk of the target audience.
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> 1/5 of the population suddenly increases output I’ve heard studies show Adderall doesn’t help people without ADHD… googling now seems to confirm. Apparently lots of people, especially college kids, take it thinking it will help, but it actually can slow them down.
My understanding is the amph. works the same in everyone - minus the edge cases. The main difference is that the magnitude is greater in people with ADHD than those without. A reduction in hyperactivity, for example, is not really apparent in people that are not overtly hyperactive to begin with. Beside, ADHD is kind of a nebulous label for a lot of symptoms. Having ADHD vs. not having ADHD is not exactly binary.
https://www.forbes.com/sites/darreonnadavis/2023/06/14/takin...
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This is about as useful as telling someone who's obese to just eat less. Factually yes, it might help them, but practically they're clearly unable to implement it, probably for a plethora of underlying reasons.
For Millennials in the US, it might be very useful. We grew up with this food pyramid being pushed at us all the time: https://en.wikipedia.org/wiki/Food_pyramid_%28nutrition%29?u... That's a lot of carbs. Only like 3 years ago did I learn they changed it around 20 years ago to be less carb-centric.
I'm Italian we eat a ton of carbs, but the pyramid I was shown as a kid decades ago had vegetables at the bottom
https://www.alimenti-salute.it/sites/default/files/sites/def...
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> Why do we find it acceptable to help people who struggle with alcohol abuse, or nicotine addiction, or opioid addiction, but not to help people who struggle with food abuse? "Getting fit and staying fit" is a form of social capital, because it's extremely hard and only within reach of a small portion of the population. "Being fit" is strongly aligned with "being attractive" which confers all sorts of cross-cutting…
In what ways is fitness not within reach for a large portion of the population?
We all can make healthier decision about what food we put into our bodies (a lot could be done to make our food supply healthier, as well). I find I have to be more strict about eating right as I get older to maintain my health.
I feel like folks saying 'fitness' isn't in reach [for most/many of us] is a cop out. This is anecdotal, but i know people who have lost 100+ lbs in their 40's and 50's and completely turned their life around; I know people who have reversed Type-2 diabetes through diet and exercise. These people have busy lives with a lot of responsibility... some of these people live in city areas where access to gyms or outdoor spaces for walking, etc. is not convenient.
I have a few doctors and other medical professionals in my family... knowing what I know, I am 'almost terrified' of becoming metabolically unhealthy and overweight. Many of the maladies that afflict us are metabolic disorders (in whole or in part) due to the long term effects of poor diet, lack of exercise & quality sleep (high stress doesn't help either). Poor metabolic health tremendously increases risk of almost every disease and malady: diabetes, heart disease, heart attack, dementia & Alzhiemer's, many cancers, stroke, depression and other mental illnesses, sleep apnea, susceptibility to infectious disease, etc. Poor metabolic health also indirectly leads to higher likelihood of issues causing chronic pain: e.g., herniated discs in the spine, ankle/knee/hip problems, migraine headaches.
I'm glad Ozempic exists but it is not a cure... it is an aid towards building a healthier life. Use Ozempic as a tool, by all means!!, to start your journey and get yourself into a better situation physically. But please use that good start to pursue the 'best/healthy you'... do it for yourself.
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GP isn't talking about self-control, they're talking about the fact we've created a system that requires obscene amounts of self-control if you wish to maintain physical health. People in the 50s weren't slimmer because they had ironclad determination to stay such.
> People in the 50s weren't slimmer because they had ironclad determination to stay such. Well, heights increased dramatically for a couple decades so what that meant was that many people in the 1950s were starving . In the 1930s, people died of starvation even in the US. I don't really think that we want to go back to starving our population just to be thin, thanks.
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I'm with you on this, tirzepatide has been life changing for me. I've struggled with my weight my whole life and I can actually imagine a future where I lose enough that I'm no longer ashamed of my weight. I've been on tirzepatide for just over a year now. Before that, I managed to lose 6% of my body weight over the previous year. With tirzepatide, I've lost an additional 17% of my body weight, for a total of 23% ove…
> It makes the difference between being so hungry that I can't fall asleep and having the ability to just go to sleep. Forgive my ignorance and curiosity, was the feeling of hunger due to drastic reduction in portion size? Could you not eat some low-calories filling food? I ask cause I've been overweight and sometimes obese most of my adult life, but when on a diet I usually feel "unsatisfied" but rarely actually hun…
While that was sometimes the case, it wasn't always so. Sometimes the feeling of hunger was almost random, and certainly stronger than it should have been. This was likely caused by insulin resistance.
When I got out of bed because I was too hungry to go to sleep I didn't always make great food choices. I'd tend to eat a 200-400 calorie 'snack', which felt like it wiped out any progress.
Now that I'm on tirzepatide I still feel hunger and cravings, but I suspect it's more in line with what regular people feel. Even if I haven't eaten much during the evening and am a little hungry at night, it's not the type of hunger that stops me from being able to get to sleep.
> Still, I'm happy for you that you found something that works!
Thanks!
I'm honestly in the category of people that have considered weight loss surgery, but I've seen enough problems from that that I've never really wanted to risk the associated problems.
From all the reading I've done it sounds like tirzepatide is almost as effective as weight loss surgery. And people are going to have a hard time convincing me that weight loss surgery is 'safer' than a GLP-1 injection.
