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Scientists may have found mechanism behind cognitive decline in aging

news.cuanschutz.edu

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Re: Scientists may have found mechanism behind cognitive decline in aging

#81

Post by fao_ »

jeffybefffy519 wrote: post #43
submeta wrote: post #35

[flagged]

I really want to know, why don't we all supplement with L-arginine long term? Time-release capsules are available and I have taken for numerous issues like RSI to great success. Whats the downside to long term usage?

One would think the first step would be to look it up.

> Most healthy people do not need to supplement with arginine because it is a component of all protein-containing foods[15] and can be synthesized in the body from glutamine via citrulline.

I do not understand how someone can wish to know something, but refuse to expend effort to obtain the information they wish to seek? I hope it would be ok for you to explain this behaviour, please?

Re: Scientists may have found mechanism behind cognitive decline in aging

#82

Post by smallkitten »

andy_ppp wrote: post #52
submeta wrote: post #35

[flagged]

> Cautious Mouthwash Use: I was under the impression that poor dental hygiene is associated with Alzheimer's disease and dementia?

Mouthwash is not really a dental hygiene thing.

If you need to use mouthwash to prevent bad breath even when you brush your teeth and clean your mouth properly, you need to look into what might be causing that problem in the first place. Mouthwash is like a duct-tape workaround and probably not very healthy for you either.

Btw - interdental toothbrushes. If you’re not using them already, you may want to start. Very helpful. Much better than flossing which has some problems associated with it.

Re: Scientists may have found mechanism behind cognitive decline in aging

#83

Post by fao_ »

esperent wrote: post #73
salad-tycoon wrote: post #68

Earlier quoted context omitted.

Side bar : L citrulline is thought to be more effective than arginine. One downside that I don’t see discussed much, as I’ve watched multiple recalls over recent years for supposed contamination of things like tmao and other toxins in either the manufacturing process or packaging process, I wonder how many supplements are contaminated. I have never seen an analysis even from the vendors who do pretty hefty chemical c…

> I wonder how many supplements are contaminated. I have never seen an analysis even from the vendors who do pretty hefty chemical composition analysis. Why do you think food supplements would be more contaminated than other processed foods? Or even things like toothpaste or shampoo, those are also made from highly processes ingredients.

There's a large amount of precedence, that's why. Rather than asking the room, one would think the first step would be to obtain information and inform yourself.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753965/

https://pubmed.ncbi.nlm.nih.gov/34022259/

https://theconversation.com/natural-supplements-can-be-dange...

Re: Scientists may have found mechanism behind cognitive decline in aging

#84

Post by copperx »

jasfi wrote: post #69
submeta wrote: post #35

[flagged]

I took beetroot as a supplement, it worked well. Ginkgo Biloba also increases nitric oxide. I've had negative effects from strong antioxidant supplements before. I think there could be a lot of reasons why.

What kind of negative effects? Cognitive ones?

Re: Scientists may have found mechanism behind cognitive decline in aging

#85

Post by matwood »

swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

> I've noticed a cognitive decline in myself the past couple years.

How have you measured? I know people do decline cognitively in old age, but 30s is still young. I wonder if people only think they were sharper when younger. I knew much less in my 20s and made tons of mistakes. The mind has a peculiar way of highlighting good memories and downplaying the bad. The person I was in my 20s would not be able to do my current job.

Re: Scientists may have found mechanism behind cognitive decline in aging

#86

Post by chownie »

fao_ wrote: post #81
jeffybefffy519 wrote: post #43

Earlier quoted context omitted.

I really want to know, why don't we all supplement with L-arginine long term? Time-release capsules are available and I have taken for numerous issues like RSI to great success. Whats the downside to long term usage?

One would think the first step would be to look it up. > Most healthy people do not need to supplement with arginine because it is a component of all protein-containing foods[15] and can be synthesized in the body from glutamine via citrulline. I do not understand how someone can wish to know something, but refuse to expend effort to obtain the information they wish to seek? I hope it would be ok for you to explain t…

This seems unfairly aggressive. GP asked what the downside is to preventatively taking l-arganine as a supplement, your quote addresses only whether it's required.

In short, you can't test your own blood so you don't know when your levels may be low. If there were no downsides to constantly supplementing then what reasons may there be to not do this?

That is I think the actual question.

Re: Scientists may have found mechanism behind cognitive decline in aging

#90

Post by Metacelsus »

submeta wrote: post #35

[flagged]

> Nitrate-Rich Diet: Consuming foods high in nitrates, such as beetroot, leafy greens, and other vegetables, might promote the production of nitric oxide.

I don't think maximizing dietary nitrate is a good idea, since the nitrite that's an intermediate in this pathway is definitely carcinogenic (forming nitrosamines).

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