Touchtyping means you should never look at the keyboard - you rely on your muscle memory and relative positioning (starting from those little ridges on two characters in the middle of the keyboard) to hit the right key. As anything related to muscle memory, like learning an instrument or playing ball, it’s all about practice.
If you decide to try a new layout, print an image of it and keep it in front of you, then load some typing tutor program (some web-based ones: keybr, keyzen, ratatype, but there are desktop ones too which typically work better than browser-based ones, because those struggle to correctly detect the actual layout) and start practicing. After a few hours, you can try your hand at something fun like Typeracer, and then it should be downhill from there.
You’ll likely have to spend a few weeks doing an hour or so of daily practice, tolerating a lower rate of typing and a higher rate of mistakes (which is the most frustrating part - try to go for precision, even if it means being slower, it will work better in the long run).
I would recommend starting over a weekend and giving it at least 4h per day, so on Monday you should be good enough to resist the inevitable pressure to switch back. I started mid-week a few times, in the evening, and it was a mistake - without significant practice, the temptation to roll back to be productive is too high.
This is my experience anyway. Spurred by a bout of wrist pain, I switched to a Kinesis Freestyle about 5 years ago, and then to Colemak a year later. I never looked back, this combination took away my wrist pain for good. I can still occasionally use qwerty without cursing too much, but the impact on my wrists is definitely noticeable compared to Colemak. Same for going back to laptop keyboards, particularly post-2016 Apple ones (admittedly I've not tried the very latest one).