Earlier quoted context omitted.
The idea that big computers and little computers were fundamentally different goes back at least as far as 1976, when I ran into Steve Jobs at Country Sun Natural Foods in Palo Alto. Both of us being hippies, we got to talking and Steve told me he'd just started a company with a friend and explained the name: "Take a byte out of the apple, get it?" He mentioned that they needed a 6502 disassembler, and I said that wa…
So what you are saying is that big computers and little computers were fundamentally the same?
The word size is different, the special areas of memory are different, it has different opcodes, and so on. But any competent machine language programmer of the day - regardless of which CPUs they'd programmed on before - would have had no trouble understanding this:
http://www.obelisk.me.uk/6502/instructions.html
That's what Steve didn't understand at the time. Not being a programmer himself, he didn't know how familiar all this would look to any machine language programmer.